Publications by Grégoire Michielin

Evolving Infectious Disease Dynamics Shape School-based Intervention Effectiveness

School-based interventions during epidemics are often controversial, as experienced during the COVID-19 pandemic, where reducing transmission had to be weighed against the adverse effects on young children. However, it remains unclear how the broader epide ...

NATURE PORTFOLIO2025

Clinical sensitivity and specificity of a high-throughput microfluidic nano-immunoassay combined with capillary blood microsampling for the identification of anti-SARS-CoV-2 Spike IgG serostatus

Grégoire Michielin, Sebastian Maerkl

ObjectivesWe evaluate the diagnostic performance of dried blood microsampling combined with a high-throughput microfluidic nano-immunoassay (NIA) for the identification of anti-SARS-CoV-2 Spike IgG seropositivity. MethodsWe conducted a serological study am ...

2023

Epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak (Alpha variant) in a primary school: A prospective longitudinal study

Grégoire Michielin, Sebastian Maerkl

Objectives ...

PUBLIC LIBRARY SCIENCE2022

A SARS-CoV-2 omicron (B.1.1.529) variant outbreak in a primary school in Geneva, Switzerland

Grégoire Michielin, Sebastian Maerkl, Idris Guessous

ELSEVIER SCI LTD2022

Direct encapsulation of biomolecules in semi-permeable microcapsules produced with double-emulsions

Grégoire Michielin, Sebastian Maerkl

Compartmentalization can serve different purposes such as the protection of biological active substances from the environment, or the creation of a unique combination of biomolecules for diagnostic, therapeutic, or other bioengineering applications. We pre ...

Nature Portfolio2022

A high-throughput microfluidic nanoimmunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultralow-volume blood samples

Grégoire Michielin, Sebastian Maerkl, Zoe Newell Swank, Hon Ming Andrew Yip

Novel technologies are needed to facilitate large-scale detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific antibodies in human blood samples. Such technologies are essential to support seroprevalence studies and vaccine clin ...

National Academy of Sciences2021

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

Grégoire Michielin

In phenylketonuria, absence or malfunction of the phenylalanine hydroxylase enzyme results in toxic accumulation of phenylalanine in the body. An injectable recombinant enzyme therapy was recently approved and has the potential to improve the quality of li ...

EPFL2021

Bottom-Up Construction of Complex Biomolecular Systems With Cell-Free Synthetic Biology

Grégoire Michielin, Sebastian Maerkl, Zoe Newell Swank, Nadanai Laohakunakorn, Barbora Lavickova, Amir Shahein, Laura Sophie Grasemann

Cell-free systems offer a promising approach to engineer biology since their open nature allows for well-controlled and characterized reaction conditions. In this review, we discuss the history and recent developments in engineering recombinant and crude e ...

2020