Publications by Giorgio Innocenti

The functional characterization of callosal connections

The brain operates through the synaptic interaction of distant neurons within flexible, often heterogeneous, distributed systems. Histological studies have detailed the connections between distant neurons, but their functional characterization deserves fur ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts

Jean-Philippe Thiran, Giorgio Innocenti, David Paul Roger Romascano, Cristina Granziera, Alessandro Daducci, Muhamed Barakovic, Gabriel Girard, Maxime Descoteaux

In the central nervous system of primates, several pathways are characterized by different spectra of axon diameters. In vivo methods, based on diffusion-weighted magnetic resonance imaging, can provide axon diameter index estimates non-invasively. However ...

2021

Comparison of diffusion MRI and CLARITY fiber orientation estimates in both gray and white matter regions of human and primate brain

Jean-Philippe Thiran, Giorgio Innocenti, Muhamed Barakovic

Diffusion MRI (dMRI) represents one of the few methods for mapping brain fiber orientations non-invasively. Unfortunately, dMRI fiber mapping is an indirect method that relies on inference from measured diffusion patterns. Comparing dMRI results with other ...

2021

On the cortical connectivity in the macaque brain: A comparison of diffusion tractography and histological tracing data

Jean-Philippe Thiran, Giorgio Innocenti, Gabriel Girard, Maxime Descoteaux, Tim Bjørn Dyrby

Diffusion-weighted magnetic resonance imaging (DW-MRI) tractography is a non-invasive tool to probe neural connections and the structure of the white matter. It has been applied successfully in studies of neurological disorders and normal connectivity. Rec ...

2020

The Target of Exuberant Projections in Development

Giorgio Innocenti

In addition to neuronal death and elimination of synapses, the production of transient, exuberant axons, and axonal branches is a general phenomenon in development across species and systems. To understand what drives the decision of which axons are mainta ...

2020

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

Jean-Philippe Thiran, Graham Knott, Giorgio Innocenti, Maxime Descoteaux, Tim Bjørn Dyrby

The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological ...

OXFORD UNIV PRESS INC2019

Topological principles and developmental algorithms might refine diffusion tractography

Jean-Philippe Thiran, Giorgio Innocenti, Alessandro Daducci, Gabriel Girard, Maxime Descoteaux, Tim Bjørn Dyrby

The identification and reconstruction of axonal pathways in the living brain or “ex-vivo” is promising a revolution in connectivity studies bridging the gap from animal to human neuroanatomy with extensions to brain structural–functional correlates. Unfort ...

2019

On the intrahemispheric connectivity of the monkey: a diffusion tractography and tract tracing analysis

Giorgio Innocenti, Gabriel Girard, Maxime Descoteaux

In this work, we compare diffusion tractography with neuronal retrograde tract tracing of the frontal, cingulate and parietal areas of the monkey. In this work, we compare diffusion tractography with neuronal retrograde tract tracing of the frontal, cingul ...

International Society for Magnetic Resonance in Medicine2019

Cortical and thalamic connectivity of occipital visual cortical areas 17, 18, 19, and 21 of the domestic ferret (Mustela putorius furo)

Giorgio Innocenti

The present study describes the ipsilateral and contralateral corticocortical and corticothalamic connectivity of the occipital visual areas 17, 18, 19, and 21 in the ferret using standard anatomical tract-tracing methods. In line with previous studies of ...

2019

Cortical and thalamic connectivity of posterior parietal visual cortical areas PPc and PPr of the domestic ferret (Mustela putorius furo)

Giorgio Innocenti

The present study describes the ipsilateral and contralateral cortico-cortical and cortico-thalamic connectivity of the parietal visual areas, posterior parietal caudal cortical area (PPc) and posterior parietal rostral cortical area (PPr), in the ferret u ...

2019

Cortical and thalamic connectivity of temporal visual cortical areas 20a and 20b of the domestic ferret (Mustela putorius furo)

Giorgio Innocenti

The present study describes the ipsilateral and contralateral corticocortical and corticothalamic connectivity of the temporal visual areas 20a and 20b in the ferret using standard anatomical tract-tracing methods. The two temporal visual areas are strongl ...

2019

Validation strategies for the interpretation of microstructure imaging using diffusion MRI

Giorgio Innocenti, Tim Bjørn Dyrby

Extracting microanatomical information beyond the image resolution of MRI would provide valuable tools for diagnostics and neuroscientific research. A number of mathematical models already suggest microstructural interpretations of diffusion MRI (dMRI) dat ...

2018

Assessing feasibility and reproducibility of a bundle-specific framework on in vivo axon diameter estimates at 300mT/m

Jean-Philippe Thiran, Giorgio Innocenti, David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Gabriel Girard, Maxime Descoteaux, Jonathan Rafael Patino Lopez

In vivo quantitative estimation of axon diameter in the white matter could bring new tools to study the structural and functional architecture of the brain. Recently, the feasibility of axon diameter estimation with diffusion-weighted MRI (DW-MRI) has been ...

2018

The Crossed Projection to the Striatum in Two Species of Monkey and in Humans: Behavioral and Evolutionary Significance

Giorgio Innocenti, Tim Bjørn Dyrby

The corpus callosum establishes the anatomical continuity between the 2 hemispheres and coordinates their activity. Using histological tracing, single axon reconstructions, and diffusion tractography, we describe a callosal projection to n caudatus and put ...

Oxford University Press2017

Organization and evolution of parieto-frontal processing streams in macaque monkeys and humans

Giorgio Innocenti

The functional organization of the parieto-frontal system is crucial for understanding cognitive-motor behavior and provides the basis for interpreting the consequences of parietal lesions in humans from a neurobiological perspective. The parieto-frontal c ...

Elsevier2015

Comments on the paper by Horowitz et al. (2014)

Giorgio Innocenti

Springer Heidelberg2015

Evolution amplified processing with temporally dispersed slow neuronal connectivity in primates

Giorgio Innocenti, Hassan Ghaziri

The corpus callosum (CC) provides the main route of communication between the 2 hemispheres of the brain. In monkeys, chimpanzees, and humans, callosal axons of distinct size interconnect functionally different cortical areas. Thinner axons in the genu and ...

National Academy of Sciences2009

Giorgio Innocenti

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The functional characterization of callosal connections

Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts

Comparison of diffusion MRI and CLARITY fiber orientation estimates in both gray and white matter regions of human and primate brain

On the cortical connectivity in the macaque brain: A comparison of diffusion tractography and histological tracing data

The Target of Exuberant Projections in Development

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

Topological principles and developmental algorithms might refine diffusion tractography

On the intrahemispheric connectivity of the monkey: a diffusion tractography and tract tracing analysis

Cortical and thalamic connectivity of occipital visual cortical areas 17, 18, 19, and 21 of the domestic ferret (Mustela putorius furo)

Cortical and thalamic connectivity of posterior parietal visual cortical areas PPc and PPr of the domestic ferret (Mustela putorius furo)

Cortical and thalamic connectivity of temporal visual cortical areas 20a and 20b of the domestic ferret (Mustela putorius furo)

Validation strategies for the interpretation of microstructure imaging using diffusion MRI

Assessing feasibility and reproducibility of a bundle-specific framework on in vivo axon diameter estimates at 300mT/m

The Crossed Projection to the Striatum in Two Species of Monkey and in Humans: Behavioral and Evolutionary Significance

Organization and evolution of parieto-frontal processing streams in macaque monkeys and humans

Comments on the paper by Horowitz et al. (2014)

Evolution amplified processing with temporally dispersed slow neuronal connectivity in primates

A Novel Interhemispheric Interaction: Modulation of Neuronal Cooperativity in the Visual Areas

Assessment of EEG synchronization based on state-space analysis

Inferring global dynamics and connectivity of neural ensembles through EEG signals