Publications by Rafaela Fernandes Da Silva

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot, Maiia Bragina, Augusto Martins Lima

Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, cont ...

ELSEVIER SCI LTD2021

Age-related changes in vascular responses to angiotensin-(1-7) in female mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Fabiana Pereira Da Costa Fraga

2018

Apelin-13 treatment enhances the stability of atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

2018

PROTECTIVE EFFECT OF APELIN-13 AGAINST HYPERCHOLESTEROLEMIA-INDUCED FIBROSIS OF THE CORPUS CAVERNOSUM

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot, Maiia Bragina, Augusto Martins Lima

2018

Apelin-13 treatment enhances the stability of atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

Oxford Univ Press2016

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced By Hypercholesterolemia

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

Wiley-Blackwell2016

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga

IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...

Wiley-Blackwell2015

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Maiia Bragina

Angiotensin (Ang) II contributes to the development of atherosclerosis, while Ang-(1-7) has atheroprotective actions. Accordingly, angiotensin-converting enzyme 2 (ACE2), which breaks-down Aug 11 and forms Ang-(1-7), has been suggested as a target against ...

Elsevier2015

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Katia Galan

Pharmacological treatments targeting CXC chemokines and the associated neutrophil activation and recruitment into atherosclerotic plaques hold promise for treating cardiovascular disorders. Therefore, we investigated whether FK866, a nicotinamide phosphori ...

Schattauer2014

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Fabiana Pereira Da Costa Fraga, Katia Galan

Angiotensin (Ang)-(1-7), acting through the receptor Mas, has athero-protective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and ...

Schattauer2014

Ace2 Is Expressed In The Corpus Cavernosum And Produces Beneficial Effects Against Hypercholesterolemic-Induced Injures

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014

Angiotensin-Converting Enzyme 2 Is Expressed In Corpus Cavernosum And Produces Beneficial Effects Against Hypercholesterolemia-Induced Injuries

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014

Arginase Inhibition Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Impairment

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014

Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye

Hypercholesterolemia is one of the most important risk factors for erectile dysfunction, mostly due to the impairment of oxidative stress and endothelial function in the penis. The cannabinoid system might regulate peripheral mechanisms of sexual function; ...

Hindawi Publishing Corporation2013

The selective pharmacologic inhibition of CXC chemokines is associated with an improvement of histological features of vulnerability in mouse atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Katia Galan

Wiley-Blackwell2013

ACE2 Activation Protects Corpus Cavernosum Impairment Induced by Hypercholesterolemia

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Fabiana Pereira Da Costa Fraga

Lippincott Williams & Wilkins2013

Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit

Rafaela Fernandes Da Silva, Jean-Christophe Copin

Aging and atherosclerosis are well-recognized risk factors for cardiac and neurovascular diseases. The Apolipoprotein E deficient (ApoE-/-) mouse on a high-fat diet is a classical model of atherosclerosis, characterized by the presence of atherosclerotic p ...

Biomed Central Ltd2012

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Katia Galan

The activation of cannabinoid receptor type 2 (CB2)-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB2 pharmacologi ...

Oxford University Press2012

Treatment with chemokine-binding protein Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke in mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Katia Galan

Academic Press Ltd- Elsevier Science Ltd2012

Recombinant tissue plasminogen activator induces blood-brain barrier breakdown by a matrix metalloproteinase-9-independent pathway after transient focal cerebral ischemia in mouse

Rafaela Fernandes Da Silva, Jean-Christophe Copin

The role of the inducible matrix metalloproteinase (MMP)-9 in blood-brain barrier (BBB) disruption after ischemic stroke is well accepted. Recombinant tissue plasminogen activator (r-tPA) is the only approved thrombolytic treatment of ischemic stroke but r ...

Wiley-Blackwell2011