Publications by Ruud van Heeswijk

Compressed sensing with signal averaging for improved sensitivity and motion artifact reduction in fluorine-19 MRI

Jérôme Yerly, Ruud van Heeswijk, Elena Najdenovska, Tobias Kober, Tom Hilbert

Fluorine-19 (F-19) MRI of injected perfluorocarbon emulsions (PFCs) allows for the non-invasive quantification of inflammation and cell tracking, but suffers from a low signal-to-noise ratio and extended scan time. To address this limitation, we tested the ...

WILEY2020

Scalable Learning-Based Sampling Optimization For Compressive Dynamic MRI

Ruud van Heeswijk, Armin Eftekhari, Volkan Cevher, Baran Gözcü, Thomas Sanchez

Compressed sensing applied to magnetic resonance imaging (MRI) allows to reduce the scanning time by enabling images to be reconstructed from highly undersampled data. In this paper, we tackle the problem of designing a sampling mask for an arbitrary recon ...

IEEE2020

Hyperpolarized 6Li as a probe for hemoglobin oxygenation level

Arnaud Comment, Rolf Gruetter, Ruud van Heeswijk, Riccardo Balzan, Mor-Miri Mishkovsky

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation o ...

Wiley-Blackwell2016

Self-Navigation with Compressed Sensing for 2D translational Motion Correction in Free-Breathing Coronary MRI: a Feasibility Study

Yves Wiaux, Ruud van Heeswijk, Gilles Puy, Gabriele Vincenzo Bonanno, Davide Piccini

Purpose Respiratory motion correction remains a challenge in coronary magnetic resonance imaging (MRI) and current techniques, such as navigator gating, suffer from sub-optimal scan efficiency and ease-of-use. To overcome these limitations, an image-based ...

Public Library of Science2014

Selective in vivo visualization of immune-cell infiltration in a mouse model of autoimmune myocarditis by fluorine-19 cardiac magnetic resonance

Ruud van Heeswijk

Background- The goal of this study was to characterize the performance of fluorine-19 ((19)F) cardiac magnetic resonance (CMR) for the specific detection of inflammatory cells in a mouse model of myocarditis. Intravenously administered perfluorocarbons are ...

2013

About the performance of multi-dimensional radial self-navigation incorporating compressed sensing for free-breathing coronary MRI

Yves Wiaux, Ruud van Heeswijk, Gilles Puy, Gabriele Vincenzo Bonanno

Respiratory motion is a major challenge in cardiac magnetic resonance imaging (MRI) and contemporary state-of-the-art motion compensation strategies like diaphragmatic navigators still suffer from sub-optimal time efficiency. In response, k-space- based on ...

2012

Fluorine-19 Magnetic Resonance Angiography of the Mouse

Yves Pilloud, Ruud van Heeswijk

Purpose: To implement and characterize a fluorine-19 (F-19) magnetic resonance imaging (MRI) technique and to test the hypothesis that the F-19 MRI signal in steady state after intravenous injection of a perfluoro-15-crown-5 ether (PCE) emulsion may be exp ...

Public Library of Science2012

Hyperpolarized 6Li as probe for hemoglobin oxygenation level

Arnaud Comment, Rolf Gruetter, Ruud van Heeswijk, Riccardo Balzan, Mor-Miri Mishkovsky

2012

A comparison of in vivo (13) C MR brain glycogen quantification at 9.4 and 14.1 T

Yves Pilloud, Rolf Gruetter, Ruud van Heeswijk

The high molecular weight and low concentration of brain glycogen render its noninvasive quantification challenging. Therefore, the precision increase of the quantification by localized (13) C MR at 9.4 to 14.1 T was investigated. Signal-to-noise ratio inc ...

Wiley2012

Multi-dimensional radial self-navigation with non-linear reconstruction for free-breathing coronary MRI

Yves Wiaux, Ruud van Heeswijk, Gilles Puy, Gabriele Vincenzo Bonanno

The main challenge for cardiac MRI is motion. To account for respiratory motion, k-space-based self- navigation approaches have recently been introduced [1]. We took self-navigation to the next level by exploiting an image-based beat-to-beat respiratory mo ...

2011

Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats

Arnaud Comment, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced vi ...

2010

Quantification of brain glycogen concentration and turnover through localized C-13 NMR of both the C1 and C6 resonances

Rolf Gruetter, Ruud van Heeswijk, Lijing Xin

We have recently shown that at isotopic steady state C-13 NMR can provide a direct measurement of glycogen concentration changes, but that the turnover of glycogen was not accessible with this protocol. The aim of the present study was to design, implement ...

Wiley-Blackwell2010

In vivo magnetic resonance studies of glycogen and hyperpolarized lithium in the rat brain

Ruud van Heeswijk

Nuclear magnetic resonance (NMR) is used for a large array of applications, ranging from chemical characterization to oil drilling to medical imaging. In these fields NMR is used as an investigational tool, but new techniques and applications are continuou ...

EPFL2009

Time-resolved measurement of rat brain glycogen absolute concentration in vivo

Sabrina Laus, Rolf Gruetter, Ruud van Heeswijk, Lijing Xin, Hanne Frenkel, Hongxia Lei

Wiley-Blackwell2009

NMR determination of brain glycogen turnover with internal labelling monitoring

Rolf Gruetter, Ruud van Heeswijk, Lijing Xin

Wiley-Blackwell2009

Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

Arnaud Comment, Jacques Van Der Klink, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

Lithium is widely used in psychotherapy. The Li-6 isotope has a long intrinsic longitudinal relaxation time T-1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can ...

Wiley-Blackwell2009

Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau

New low-temperature inserts compatible with an existing hyperpolarizer were developed to dynamically polarize nuclei in large samples. The performance of the system was tested on 8 ml glassy frozen solutions containing 13C-labeled molecules and doped with ...

Academic Press Inc - Elsevier Science2008

In Vivo Detection of Hyperpolarized 15N Choline in the Rat

Arnaud Comment, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

2008

Non-invasive quantification of brain glycogen absolute concentration

Sabrina Laus, Rolf Gruetter, Ruud van Heeswijk, Lijing Xin, Hanne Frenkel, Hongxia Lei

The only currently available method to measure brain glycogen in vivo is C-13 NMR spectroscopy. Incorporation of C-13-labeled glucose (Glc) is necessary to allow glycogen measurement, but might be affected by turnover changes. Our aim was to measure glycog ...

Wiley-Blackwell2008

Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions

Sabrina Laus, Rolf Gruetter, Ruud van Heeswijk

The relaxivity of commercially available gadolinium (Gd)-based contrast agents was studied for X-nuclei resonances with long intrinsic relaxation times ranging from 6 s to several hundred seconds. Omniscan in pure 13C formic acid had a relaxivity of 2.9 mM ...

Elsevier2007