Publications by Friedrich Beermann

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway

Metastatic melanoma is hallmarked by its ability of phenotype switching to more slowly proliferating, but highly invasive cells. Here, we tested the impact of signal transducer and activator of transcription 3 (STAT3) on melanoma progression in association ...

SPRINGERNATURE2021

AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress

Friedrich Beermann, Freddy Radtke, Marzia Armaro, Ute Koch, Marion Leleu, Alain Kfoury

2018

Haplosufficiency of PAX3 for melanoma development in Tyr: NRASQ61K; Cdkn2a-/- mice allows identification and sorting of melanoma cells using a Pax3GFP reporter allele

Friedrich Beermann

The role of the Pax3 gene in embryonic development of pigment cells is well characterized. By contrast, the function of Pax3 in melanoma development is controversial. Indeed, data obtained from cultured cells suggest that PAX3 may contribute to melanomagen ...

Lippincott Williams & Wilkins2016

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

Friedrich Beermann, Rong Wu, Li Li, Yi Zhang, Jie Zhang, Qian Zhang, Ang Li, Ping Chen, Bo Zhou, Yuan Liu

Autophagy is linked to cell death, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear ...

Nature Publishing Group2014

Histopathological atlas and proposed classification for melanocytic lesions in Tyr::NRas(Q61K) ; Cdkn2a(-/-) transgenic mice

Friedrich Beermann

Wiley-Blackwell2013

The Channel-Activating Protease CAP1/Prss8 Is Required for Placental Labyrinth Maturation

Aline Dousse, Friedrich Beermann, Simona Frateschi, Roch-Philippe Charles

The serine protease CAP1/Prss8 is crucial for skin barrier function, lung alveolar fluid clearance and has been unveiled as diagnostic marker for specific cancer types. Here, we show that a constitutive knockout of CAP1/Prss8 leads to embryonic lethality. ...

Public Library of Science2013

Role of the Epigenetic Modifier EZH2 in Melanoma

Lukas Sommer, Friedrich Beermann

Wiley-Blackwell2013

Precise toxigenic ablation of intermediate cells abolishes the "battery" of the cochlear duct

Friedrich Beermann

The extracellular potential of excitable and nonexcitable cells with respect to ground is ∼0 mV. One of the known exceptions in mammals is the cochlear duct, where the potential is ∼80-100 mV, called the endocochlear potential (EP). The EP serves as the "b ...

Society for Neuroscience2013

A Subpopulation of Smooth Muscle Cells, Derived from Melanocyte-Competent Precursors, Prevents Patent Ductus Arteriosus

Friedrich Beermann

Background: Patent ductus arteriosus is a life-threatening condition frequent in premature newborns but also present in some term infants. Current mouse models of this malformation generally lead to perinatal death, not reproducing the full phenotypic spec ...

Public Library of Science2013

Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

Yann Barrandon, Stéphanie Claudinot, Lukas Sommer, Friedrich Beermann

Giant congenital naevi are pigmented childhood lesions that frequently lead to melanoma, the most aggressive skin cancer. The mechanisms underlying this malignancy are largely unknown, and there are no effective therapies. Here we describe a mouse model fo ...

Nature Publishing Group2012

Carcinogen treatment in mouse selectively expressing activated N-Ras(Q61K) in melanocytes recapitulates metastatic cutaneous melanoma development

Friedrich Beermann

The incidence of melanoma has significantly increased and a better understanding its pathogenesis and development of new therapeutic strategies are urgently needed. Here we describe a murine model of metastatic cutaneous melanoma using C57BL/6 mice express ...

2012

The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility

Friedrich Beermann, Anne Wilson, Roman Chrast, Jian Wang

The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in v ...

2012

Constitutive gray hair in Mice induced by Melanocyte-specific deletion of c-Myc

Friedrich Beermann, Karine Schouwey, Marzia Armaro

c-Myc is involved in the control of diverse cellular processes and implicated in the maintenance of different tissues including the neural crest. Here we report that c-Myc is particularly important for pigment cell development and homeostasis. Targeting c- ...

2012

Coat color dilution in mice because of inactivation of the melanoma antigen MART-1

Friedrich Beermann, Iraz Toprak Aydin

Melanoma antigen recognized by T cells 1 (MART-1) is a melanoma-specific antigen, which has been thoroughly studied in the context of immunotherapy against malignant melanoma and which is found only in the pigment cell lineage. However, its exact function ...

2012

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

Friedrich Beermann, Ang Li

Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the Western world. Molecular pathways that drive melanoblast migration in development are believed to underpin the movement and ...

Nature Research2011

A MART-1::Cre transgenic line induces recombination in melanocytes and RPE

Friedrich Beermann, Iraz Toprak Aydin

The number of transgenic mouse lines expressing Cre in either type of pigment cells (melanocytes and retinal pigment epithelium, RPE) is limited, and the available lines do not always offer sufficient specificity. In this study, we addressed this issue and ...

2011

RBP-Jκ-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice

Friedrich Beermann, Iraz Toprak Aydin, Freddy Radtke

The Notch signaling pathway is an ubiquitous cell-cell interaction mechanism, which is essential in controlling processes like cell proliferation, cell fate decision, differentiation or stem cell maintenance. Recent data have shown that Notch signaling is ...

Nature Publishing Group2011

Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses

Friedrich Beermann

B-cell-activating factor of the TNF family (BAFF)/BLyS contributes to B-cell homeostasis and function in the periphery. BAFF is expressed as a membrane-bound protein or released by proteolytic cleavage, but the functional importance of this processing even ...

Wiley2011

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

Friedrich Beermann, Anne Wilson, Simona Frateschi, Roch-Philippe Charles

Altered serine protease activity is associated with skin disorders in humans and in mice. The serine protease channel-activating protease-1 (CAP1; also termed protease serine S1 family member 8 (Prss8)) is important for epidermal homeostasis and is thus in ...

Nature Research2011

Transgenic expression of Notch in melanocytes demonstrates RBP-Jkappa-dependent signaling

Friedrich Beermann, Karine Schouwey, Freddy Radtke

2010