Publications by James Gonzalo King

A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers

Henry Markram, James Gonzalo King, Daniel Keller, Polina Shichkova, James Bryden Isbister, Darshan Mandge, Alessandro Cattabiani

The high energetic demands of the brain arise primarily from neuronal activity. Neurons consume substantial energy to transmit information as electrical signals and maintain their resting membrane potential. These energetic requirements are met by the neur ...

Public Library of Science (PLoS)2025

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Kathryn Hess Bellwald, Henry Markram, Felix Schürmann, James Gonzalo King, Srikanth Ramaswamy, Juan Bautista Hernando Vieites, Alexis Arnaudon, Eilif Benjamin Muller, Daniel Keller, Michael Reimann, Huanxiang Lu, Ying Shi, Vishal Sood, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Lida Kanari, Juan Luis Riquelme Roman, Ran Levi, Michael Emiel Gevaert, Pramod Shivaji Kumbhar, Liesbeth Maria L Vanherpe, Armando Romani, Cyrille Pierre Henri Favreau, Judit Planas Carbonell, Adrien Michel Achille Devresse, András Ecker, Nicolas René Jean Ninin, Daniela Egas Santander, Alexander Dietz, Benoît Jean-Albert Coste, Samuel Lieven D. Lapere, Matthias Wolf, Sirio Bolaños Puchet, Hugo Thabo Dictus, Thomas Brice Delemontex, James Bryden Isbister, Janis Lazovskis, Gianluca Ficarelli, Joni Henrikki Herttuainen,

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

James Gonzalo King, Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Giuseppe Chindemi, Pramod Shivaji Kumbhar, András Ecker, Daniela Egas Santander, Ioannis Magkanaris, Sirio Bolaños Puchet, Jorge Blanco Alonso, James Bryden Isbister

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

2024

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Henry Markram, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Alexis Arnaudon, Eilif Benjamin Muller, Daniel Keller, Michael Reimann, Vishal Sood, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Giuseppe Chindemi, Michael Emiel Gevaert, Pramod Shivaji Kumbhar, Armando Romani, Christian Andreas Rössert, Judit Planas Carbonell, Genrich Ivaska, András Ecker, Daniela Egas Santander, Natali Barros Zulaica, Alexander Dietz, Omar Awile, Samuel Lieven D. Lapere, Matthias Wolf, Sirio Bolaños Puchet, Thomas Brice Delemontex, Jorge Blanco Alonso, Mustafa Anil Tuncel, Tanguy Pierre Louis Damart, Maria Reva, James Bryden Isbister, Darshan Mandge, Weina Ji, Aleksandra Zuzanna Teska, Polina Litvak, Gianluca Ficarelli, Joni Henrikki Herttuainen, ,

Community-based reconstruction and simulation of a full-scale model of region CA1 of rat hippocampus

Henry Markram, Felix Schürmann, James Gonzalo King, Srikanth Ramaswamy, Juan Bautista Hernando Vieites, Alexis Arnaudon, Eilif Benjamin Muller, Michael Reimann, Huanxiang Lu, Ying Shi, Marwan Muhammad Ahmed Abdellah, Vishal Sood, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Lida Kanari, Juan Luis Riquelme Roman, Michael Emiel Gevaert, Pramod Shivaji Kumbhar, Liesbeth Maria L Vanherpe, Armando Romani, Cyrille Pierre Henri Favreau, Michele Migliore, Mohameth François Sy, Szabolcs Kali, Judit Planas Carbonell, Genrich Ivaska, Sàra Sàray, Carmen Alina Lupascu, Rosanna Migliore, Audrey Mercer, András Ecker, Alberto Antonietti, Cristina Colangelo, Anna-Kristin Kaufmann, Julian Martin Budd, Elisabetta Giacalone, Thomas Brice Delemontex, Davide Bella, Fabien Petitjean, , , , ,

Search for high-mass exclusive diphoton production with tagged protons in proton-proton collisions at √s=13 TeV

Patrick Berger, Rakesh Chawla, Ian Smith, Jung Eung Park, Thomas Mountford, Matthias Finger, Matteo Galli, Maria Isabel Cordero Campana, Xiaoqiang Wang, Jian Zhao, James Gonzalo King, Mirko Kovac, Hua Zhang, Joo Yeon Kim, Jae-Woo Choi, Pedro Camilo de Oliveira e Silva, Young Min Kim, Myun Sik Kim, Gabriele Grosso, Qian Wang, Varun Sharma, Michele De Palma, Hyungjun Lee, Chia-Chun Chen, Siyuan Wang, Özdemir Can Kara, Shivom Sharma, Jian Wang, Yi Zhang, Bokyoung Kim, Rahul Kumar Gupta, Ling Zhou, Mithlesh Kumar, Chenyang Wang, Matthias Wolf, Chang-Hyun Park, Anna Mascellani, Yikai Yang, Zhenyu Wang, Seonwoo Lee, Wei-Hsiang Lin, , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Simplification of spiking neural network models

Wulfram Gerstner, Henry Markram, Christian Antonio Pozzorini, James Gonzalo King, Eilif Benjamin Muller, Csaba Erö, Idan Segev, Willem Anna Mark Wybo, Christian Andreas Rössert

The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron ...

2024

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Henry Markram, Rodrigo de Campos Perin, James Gonzalo King, Rajnish Ranjan, Grigori Chevtchenko, Sean Lewis Hill, Jayakrishnan Harikrishnavilas Raveendran Nair, Michael Reimann, Ying Shi, Marwan Muhammad Ahmed Abdellah, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Adrien Christian Fleury, Michael Emiel Gevaert, Pramod Shivaji Kumbhar, Oren Amsalem, Cyrille Pierre Henri Favreau, Mohameth François Sy, Samuel Claude Kerrien, Elisabetta Iavarone, Christian O'Reilly, Genrich Ivaska, András Ecker, Anna-Kristin Kaufmann, Benoît Jean-Albert Coste, Ioannis Magkanaris, Matthias Wolf, Marine Laure Bertschy, Patrycja Lurie, Mustafa Anil Tuncel, Fabien Petitjean, Nadir Roman Guerrero, Liviu Soltuzu, Alexander Désiré Ulbrich, Polina Litvak, Vignayanandam Ravindernath Muddapu, Joni Henrikki Herttuainen

2023

STEPS 4.0: Fast and memory-efficient molecular simulations of neurons at the nanoscale

Felix Schürmann, James Gonzalo King, Christos Kotsalos, Pramod Shivaji Kumbhar, Iain Hepburn, Weiliang Chen, Tristan Mathieu Carel, Samuel Marie A Melchior, Omar Awile, Baudouin Paul Michel Maria Joseph Del Marmol, Alessandro Cattabiani, Giacomo Castiglioni, Nicola Cantarutti

Recent advances in computational neuroscience have demonstrated the usefulness and importance of stochastic, spatial reaction-diffusion simulations. However, ever increasing model complexity renders traditional serial solvers, as well as naive parallel imp ...

FRONTIERS MEDIA SA2022

Modernizing the NEURON Simulator for Sustainability, Portability, and Performance

Felix Schürmann, James Gonzalo King, Pramod Shivaji Kumbhar, Omar Awile, Ioannis Magkanaris

The need for reproducible, credible, multiscale biological modeling has led to the development of standardized simulation platforms, such as the widely-used NEURON environment for computational neuroscience. Developing and maintaining NEURON over several d ...

2022

High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons

James Gonzalo King, Suraj Honnuraiah

Neurons receive synaptic input primarily onto their dendrites. While we know much about the electrical properties of dendrites in rodents, we have only just started to describe their properties in the human brain. Here, we investigate the capacity of human ...

2022

A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex

Henry Markram, Vincent Delattre, Rodrigo de Campos Perin, James Gonzalo King, Eilif Benjamin Muller, Marwan Muhammad Ahmed Abdellah, Werner Alfons Hilda Van Geit, Giuseppe Chindemi, Aurélien Tristan Jaquier, Pramod Shivaji Kumbhar, Christian Andreas Rössert, András Ecker, Mustafa Anil Tuncel

Pyramidal cells (PCs) form the backbone of the layered structure of the neocortex, and plasticity of their synapses is thought to underlie learning in the brain. However, such long-term synaptic changes have been experimentally characterized between only a ...

Nature Portfolio2022

An Optimizing Multi-platform Source-to-source Compiler Framework for the NEURON MODeling Language

Felix Schürmann, James Gonzalo King, Michael Lee Hines, Pramod Shivaji Kumbhar, Omar Awile, Jorge Blanco Alonso, Liam Roger George Keegan

Domain-specific languages (DSLs) play an increasingly important role in the generation of high performing software. They allow the user to exploit domain knowledge for the generation of more efficient code on target architectures. Here, we describe a new c ...

Springer2020

The SONATA data format for efficient description of large-scale network models

James Gonzalo King, Juan Bautista Hernando Vieites, Eilif Benjamin Muller, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Michael Emiel Gevaert, Judit Planas Carbonell, Adrien Michel Achille Devresse

Increasing availability of comprehensive experimental datasets and of high-performance computing resources are driving rapid growth in scale, complexity, and biological realism of computational models in neuroscience. To support construction and simulation ...

2020

CoreNEURON : An Optimized Compute Engine for the NEURON Simulator

Felix Schürmann, James Gonzalo King, Michael Lee Hines, Fabien Jonathan Delalondre, Aleksandr Ovcharenko, Pramod Shivaji Kumbhar, Jérémy Pierre Benoit Fouriaux

The NEURON simulator has been developed over the past three decades and is widely used by neuroscientists to model the electrical activity of neuronal networks. Large network simulation projects using NEURON have supercomputer allocations that individually ...

2019

Cortical reliability amid noise and chaos

Henry Markram, James Gonzalo King, Eilif Benjamin Muller, Michael Reimann, Max Christian Nolte

Typical responses of cortical neurons to identical sensory stimuli appear highly variable. It has thus been proposed that the cortex primarily uses a rate code. However, other studies have argued for spike-time coding under certain conditions. The potentia ...

Nature Research2019

Simplification of neural network models

Wulfram Gerstner, Henry Markram, Christian Antonio Pozzorini, James Gonzalo King, Eilif Benjamin Muller, Csaba Erö, Idan Segev, Marc-Oliver Gewaltig, Willem Anna Mark Wybo, Christian Andreas Rössert

The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron ...

2018

Leveraging a Cluster-Booster Architecture for Brain-Scale Simulations

Felix Schürmann, James Gonzalo King, Michael Lee Hines, Aleksandr Ovcharenko, Pramod Shivaji Kumbhar

The European Dynamical Exascale Entry Platform (DEEP) is an example of a new type of heterogeneous supercomputing architecture that include both a standard multicore-based "Cluster" used to run less scalable parts of an application, and an Intel MIC-based ...

Springer Int Publishing Ag2016

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Selim Arsever, Henry Markram, Raphael Dumusc, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Sean Lewis Hill, Juan Bautista Hernando Vieites, Eilif Benjamin Muller, Daniel Keller, Idan Segev, Michael Reimann, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, Stefan Eilemann, Guy Antoine Atenekeng Kahou, Jeffrey Christopher Muller, Lida Kanari, Stefano Zaninetta, Giuseppe Chindemi, Jafet Villafranca Diaz, Yury Brukau, Michael Emiel Gevaert, Stanislaw Ryszard Adaszewski, Nicolas Antille

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

2015

Reconstruction and Simulation of Neocortical Microcircuitry

Nenad Buncic, Jean-Vincent Le Bé, Selim Arsever, Henry Markram, Gilad Silberberg, Sébastien Lasserre, Vincent Delattre, Raphael Dumusc, Rodrigo de Campos Perin, Imad Riachi, Thomas Berger, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Michael Lee Hines, Sean Lewis Hill, Juan Bautista Hernando Vieites, Georges Khazen, Shruti Muralidhar, Anastasia Ailamaki, Eilif Benjamin Muller, Farhan Tauheed, Jean Pierre Ghobril, Julie Meystre, Daniel Keller, Idan Segev, Michael Reimann, Thomas Heinis, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, , , , , , , , , , , , , , , , , , , , , , , , , , , ,