Publications by Srikanth Ramaswamy

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Kathryn Hess Bellwald, Henry Markram, Felix Schürmann, James Gonzalo King, Srikanth Ramaswamy, Juan Bautista Hernando Vieites, Alexis Arnaudon, Eilif Benjamin Muller, Daniel Keller, Michael Reimann, Huanxiang Lu, Ying Shi, Vishal Sood, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Lida Kanari, Juan Luis Riquelme Roman, Ran Levi, Michael Emiel Gevaert, Pramod Shivaji Kumbhar, Liesbeth Maria L Vanherpe, Armando Romani, Cyrille Pierre Henri Favreau, Judit Planas Carbonell, Adrien Michel Achille Devresse, András Ecker, Nicolas René Jean Ninin, Daniela Egas Santander, Alexander Dietz, Benoît Jean-Albert Coste, Samuel Lieven D. Lapere, Matthias Wolf, Sirio Bolaños Puchet, Hugo Thabo Dictus, Thomas Brice Delemontex, James Bryden Isbister, Janis Lazovskis, Gianluca Ficarelli, Joni Henrikki Herttuainen,

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Henry Markram, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Alexis Arnaudon, Eilif Benjamin Muller, Daniel Keller, Michael Reimann, Vishal Sood, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Giuseppe Chindemi, Michael Emiel Gevaert, Pramod Shivaji Kumbhar, Armando Romani, Christian Andreas Rössert, Judit Planas Carbonell, Genrich Ivaska, András Ecker, Daniela Egas Santander, Natali Barros Zulaica, Alexander Dietz, Omar Awile, Samuel Lieven D. Lapere, Matthias Wolf, Sirio Bolaños Puchet, Thomas Brice Delemontex, Jorge Blanco Alonso, Mustafa Anil Tuncel, Tanguy Pierre Louis Damart, Maria Reva, James Bryden Isbister, Darshan Mandge, Weina Ji, Aleksandra Zuzanna Teska, Polina Litvak, Gianluca Ficarelli, Joni Henrikki Herttuainen, ,

Community-based reconstruction and simulation of a full-scale model of region CA1 of rat hippocampus

Henry Markram, Felix Schürmann, James Gonzalo King, Srikanth Ramaswamy, Juan Bautista Hernando Vieites, Alexis Arnaudon, Eilif Benjamin Muller, Michael Reimann, Huanxiang Lu, Ying Shi, Marwan Muhammad Ahmed Abdellah, Vishal Sood, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Lida Kanari, Juan Luis Riquelme Roman, Michael Emiel Gevaert, Pramod Shivaji Kumbhar, Liesbeth Maria L Vanherpe, Armando Romani, Cyrille Pierre Henri Favreau, Michele Migliore, Mohameth François Sy, Szabolcs Kali, Judit Planas Carbonell, Genrich Ivaska, Sàra Sàray, Carmen Alina Lupascu, Rosanna Migliore, Audrey Mercer, András Ecker, Alberto Antonietti, Cristina Colangelo, Anna-Kristin Kaufmann, Julian Martin Budd, Elisabetta Giacalone, Thomas Brice Delemontex, Davide Bella, Fabien Petitjean, , , , ,

A universal workflow for creation, validation and generalization of detailed neuronal models

Henry Markram, Srikanth Ramaswamy, Alexis Arnaudon, Werner Alfons Hilda Van Geit, Christian Andreas Rössert, Mustafa Anil Tuncel, Tanguy Pierre Louis Damart, Maria Reva, Darshan Mandge

Detailed single neuron modeling is widely used to study neuronal functions. While cellular and functional diversity across the mammalian cortex is vast, most of the available computational tools are dedicated to the reproduction of a small set of specific ...

Cambridge2023

Mapping of morpho-electric features to molecular identity of cortical inhibitory neurons

Henry Markram, Srikanth Ramaswamy, Daniel Keller, Michael Reimann, Yann Roussel, Dimitri Bruno Marie Rodarie, Tanguy Pierre Louis Damart

Author summaryThe computational abilities of the brain arise from its organization principles at the cellular level. One of these principles is the neuronal type composition over different regions. Since computational functions of neurons are best describe ...

2023

2022 roadmap on neuromorphic computing and engineering

Emre Neftci, Srikanth Ramaswamy, Roberto Galeazzi, Yihwa Kim, Silvia Tolu, Abu Sebastian, Carlo Ricciardi, Xuan Li, Elisa Donati

Modern computation based on von Neumann architecture is now a mature cutting-edge science. In the von Neumann architecture, processing and memory units are implemented as separate blocks interchanging data intensively and continuously. This data transfer i ...

IOP Publishing Ltd2022

Computational Concepts for Reconstructing and Simulating Brain Tissue

Felix Schürmann, Srikanth Ramaswamy, Jean-Denis Georges Emile Courcol

It has previously been shown that it is possible to derive a new class of biophysically detailed brain tissue models when one computationally analyzes and exploits the interdependencies or the multi-modal and multi-scale organization of the brain. These re ...

Springer2022

A method to estimate the cellular composition of the mouse brain from heterogeneous datasets

Henry Markram, Srikanth Ramaswamy, Daniel Keller, Michael Reimann, Marc-Oliver Gewaltig, Yann Roussel, Dimitri Bruno Marie Rodarie

The mouse brain contains a rich diversity of inhibitory neuron types that have been characterized by their patterns of gene expression. However, it is still unclear how these cell types are distributed across the mouse brain. We developed a computational m ...

2022

Data-driven integration of hippocampal CA1 synaptic physiology in silico

Srikanth Ramaswamy, Eilif Benjamin Muller, Michael Reimann, Armando Romani, Michele Migliore, Szabolcs Kali, Sàra Sàray, Audrey Mercer, András Ecker

The anatomy and physiology of monosynaptic connections in rodent hippocampal CA1 have been extensively studied in recent decades. Yet, the resulting knowledge remains disparate and difficult to reconcile. Here, we present a data-driven approach to integrat ...

2020

A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity

Srikanth Ramaswamy, Vignayanandam Ravindernath Muddapu

Parkinson's disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta (SNc). Although many mechanisms have been suggested, a decisive root cause of this cell loss is ...

2019

Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex

Henry Markram, Rodrigo de Campos Perin, Srikanth Ramaswamy, Eilif Benjamin Muller, Giuseppe Chindemi, Natali Barros Zulaica

Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis ...

2019

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Henry Markram, Srikanth Ramaswamy, Daniel Keller, Cristina Colangelo, Polina Shichkova

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...

2019

Objective Morphological Classification of Neocortical Pyramidal Cells

Kathryn Hess Bellwald, Henry Markram, Rodrigo de Campos Perin, Srikanth Ramaswamy, Julie Meystre, Yun Wang, Ying Shi, Marwan Muhammad Ahmed Abdellah, Lida Kanari

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, w ...

Oxford University Press (OUP)2019

Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity

Henry Markram, Srikanth Ramaswamy, Cristina Colangelo

Neuromodulators, such as acetylcholine (ACh), control information processing in neural microcircuits by regulating neuronal and synaptic physiology. Computational models and simulations enable predictions on the potential role of ACh in reconfiguring netwo ...

2018

Morphological Diversity Strongly Constrains Synaptic Connectivity and Plasticity

Henry Markram, Srikanth Ramaswamy, Eilif Benjamin Muller, Michael Reimann, Anna-Lena Horlemann

Synaptic connectivity between neurons is naturally constrained by the anatomical overlap of neuronal arbors, the space on the axon available for synapses, and by physiological mechanisms that form synapses at a subset of potential synapse locations. What i ...

Oxford University Press (OUP)2017

Rich cell-type-specific network topology in neocortical microcircuitry

Henry Markram, Srikanth Ramaswamy, Eilif Benjamin Muller, Idan Segev, Michael Reimann, Eyal Gal, Michael London

Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a similar to 0.3-mm(3) volum ...

Nature Publishing Group2017

Unique Maturation Trajectories of Basket and Chandelier Cells in the Neocortex

Srikanth Ramaswamy

Soc Neuroscience2017

Distinct Activity Profiles of Somatostatin-Expressing Interneurons in the Neocortex

Srikanth Ramaswamy, Eilif Benjamin Muller, Cristina Colangelo

Frontiers Media Sa2017

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Selim Arsever, Henry Markram, Raphael Dumusc, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Sean Lewis Hill, Juan Bautista Hernando Vieites, Eilif Benjamin Muller, Daniel Keller, Idan Segev, Michael Reimann, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, Stefan Eilemann, Guy Antoine Atenekeng Kahou, Jeffrey Christopher Muller, Lida Kanari, Stefano Zaninetta, Giuseppe Chindemi, Jafet Villafranca Diaz, Yury Brukau, Michael Emiel Gevaert, Stanislaw Ryszard Adaszewski, Nicolas Antille

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

2015

Reconstruction and Simulation of Neocortical Microcircuitry

Nenad Buncic, Jean-Vincent Le Bé, Selim Arsever, Henry Markram, Gilad Silberberg, Sébastien Lasserre, Vincent Delattre, Raphael Dumusc, Rodrigo de Campos Perin, Imad Riachi, Thomas Berger, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Michael Lee Hines, Sean Lewis Hill, Juan Bautista Hernando Vieites, Georges Khazen, Shruti Muralidhar, Anastasia Ailamaki, Eilif Benjamin Muller, Farhan Tauheed, Jean Pierre Ghobril, Julie Meystre, Daniel Keller, Idan Segev, Michael Reimann, Thomas Heinis, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, , , , , , , , , , , , , , , , , , , , , , , , , , , ,