Publications by Nouchine Hadjikhani

Ultrahigh field in vivo characterization of microstructural abnormalities in the orbitofrontal cortex and amygdala in autism

Nouchine Hadjikhani, Guillaume Bonnier, Elda Fischi Gomez, Cristina Granziera

There are currently no biomarkers for autism spectrum disorder (ASD). This neurodevelopmental condition has previously been associated with histopathological findings, including increased neuronal packing density in the amygdala, abnormal laminar cytoarchi ...

2021

The Number of Genomic Copies at the 16p11.2 Locus Modulates Language, Verbal Memory, and Inhibition

Nouchine Hadjikhani, Loyse Hippolyte, Bogdan Draganski, Borja Rodriguez Herreros

BACKGROUND: Deletions and duplications of the 16p11.2 BP4-BP5 locus are prevalent copy number variations (CNVs), highly associated with autism spectrum disorder and schizophrenia. Beyond language and global cognition, neuropsychological assessments of thes ...

Elsevier Science Inc2016

Improving emotional face perception in autism with diuretic bumetanide: A proof-of-concept behavioral and functional brain imaging pilot study

Nouchine Hadjikhani, Ophélie Rogier, Loyse Hippolyte, Torsten Ruest

Clinical observations have shown that GABA-acting benzodiazepines exert paradoxical excitatory effects in autism, suggesting elevated intracellular chloride (Cl-)(i) and excitatory action of GABA. In a previous double-blind randomized study, we have shown ...

Sage Publications Ltd2015

The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

Nouchine Hadjikhani, Loyse Hippolyte

Anatomical structures and mechanisms linking genes to neuropsychiatric disorders are not deciphered. Reciprocal copy number variants at the 16p11.2 BP4-BP5 locus offer a unique opportunity to study the intermediate phenotypes in carriers at high risk for a ...

Nature Publishing Group2015

Emotional contagion for pain is intact in autism spectrum disorders

Nouchine Hadjikhani, Ophélie Rogier, Loyse Hippolyte, Torsten Ruest

Perceiving others in pain generally leads to empathic concern, consisting of both emotional and cognitive processes. Empathy deficits have been considered as an element contributing to social difficulties in individuals with autism spectrum disorders (ASD) ...

Nature Publishing Group2014

The missing link: Enhanced functional connectivity between amygdala and visceroceptive cortex in migraine

Nouchine Hadjikhani

Background Migraine is a neurovascular disorder in which altered functional connectivity between pain-modulating circuits and the limbic system may play a role. Cortical spreading depression (CSD), which underlies migraine aura (MWA), induces C-fos express ...

Sage Publications Ltd2013

Structural abnormalities in the thalamus of migraineurs with aura: a multiparametric study at 3T

Nouchine Hadjikhani, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alessandro Daducci, Alexis Roche

Background and objectives: The thalamus exerts a pivotal role in pain processing and cortical excitability control, and migraine is characterized by repeated pain attacks and abnormal cortical habituation to excitatory stimuli. This work aimed at studying ...

Wiley-Blackwell2013

Perception of Social Cues of Danger in Autism Spectrum Disorders

Nouchine Hadjikhani, Britt Russo, Ophélie Rogier, Loyse Hippolyte, Torsten Ruest

Intuitive grasping of the meaning of subtle social cues is particularly affected in autism spectrum disorders (ASD). Despite their relevance in social communication, the effect of averted gaze in fearful faces in conveying a signal of environmental threat ...

Public Library Science2013

It's All in the Eyes: Subcortical and Cortical Activation during Grotesqueness Perception in Autism

Nouchine Hadjikhani, Britt Russo, Ophélie Rogier, Loyse Hippolyte

Atypical face processing plays a key role in social interaction difficulties encountered by individuals with autism. In the current fMRI study, the Thatcher illusion was used to investigate several aspects of face processing in 20 young adults with high-fu ...

Public Library Science2013

Migraineurs without aura show microstructural abnormalities in the cerebellum and frontal lobe

Nouchine Hadjikhani, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alessandro Daducci, Alexis Roche

The involvement of the cerebellum in migraine pathophysiology is not well understood. We used a biparametric approach at high-field MRI (3 T) to assess the structural integrity of the cerebellum in 15 migraineurs with aura (MWA), 23 migraineurs without aur ...

Springer US2013

Investigating Gaze of Children with ASD in Naturalistic Settings

Aude Billard, Basilio Noris, Nouchine Hadjikhani

Background: Visual behavior is known to be atypical in Autism Spectrum Disorders (ASD). Monitor-based eye-tracking studies have measured several of these atypicalities in individuals with Autism. While atypical behaviors are known to be accentuated during ...

Public Library of Science2012

Structural abnormalities in the thalamus of migraine patients: a multi-parametric study at high field

Nouchine Hadjikhani, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alessandro Daducci, Alexis Roche

2012

A new early and automated MRI-based predictor of motor improvement after stroke

Jean-Philippe Thiran, Djalel Eddine Meskaldji, Reto Meuli, Nouchine Hadjikhani, Gunnar Krüger, Cristina Granziera, Alessandro Daducci, Alexis Roche, Richard Frackowiak

Objectives: In this study, we investigated the structural plasticity of the contralesional motor network in ischemic stroke patients using diffusion magnetic resonance imaging (MRI) and explored a model that combines a MRI-based metric of contralesional ne ...

2012

A 7 tesla FMRI study of amygdala responses to fearful faces

Nouchine Hadjikhani, Wietske Van der Zwaag, Nicole Regula Zürcher Wimmer

The amygdalae are involved in the perception of emotions such as happiness, anger and fear. Because of their proximity to the sinuses, the image signal intensity in T2* weighted fMRI data is often affected by signal loss due to through-slice dephasing, esp ...

2012

Developmental Prosopagnosia In A Patient With Hypoplasia Of The Vermis Cerebelli

Qing Zhu, Nouchine Hadjikhani

2012

Amygdala responses to averted vs direct gaze fear vary as a function of presentation speed

Nouchine Hadjikhani

We examined whether amygdala responses to rapidly presented fear expressions are preferentially tuned to averted vs direct gaze fear and conversely whether responses to more sustained presentations are preferentially tuned to direct vs averted gaze fear. W ...

Oxford University Press2012

A randomised controlled trial of bumetanide in the treatment of autism in children

Nouchine Hadjikhani

Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility that like in epilepsies, GABA excites ...

Nature Publishing Group2012

Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056

Nouchine Hadjikhani, Fei Chen

Fragile X syndrome (FXS) is an X-linked condition associated with intellectual disability and behavioral problems. It is caused by expansion of a CGG repeat in the 5' untranslated region of the fragile X mental retardation 1 (FMR1) gene. This mutation is a ...

2011

Stimulus duration can change polarity of BOLD response in the amygdalae: a 7T fMRI study

Nouchine Hadjikhani, Wietske Van der Zwaag, Nicole Regula Zürcher Wimmer

2011

Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray networks in migraine

Nouchine Hadjikhani

Objective: The periaqueductal gray matter (PAG), a known modulator of somatic pain transmission, shows evidence of interictal functional and structural abnormalities in migraineurs, which may contribute to hyperexcitability along spinal and trigeminal noci ...

2011