Publications by Sean Lewis Hill

BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

Pascal Fua, Sean Lewis Hill, Amos Sironi, Jiancheng Yang, Jian Zhou, Siqi Liu, Xiang Li, Jie Zhou

BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species that is representative of the data obtained in m ...

2023

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Henry Markram, Rodrigo de Campos Perin, James Gonzalo King, Rajnish Ranjan, Grigori Chevtchenko, Sean Lewis Hill, Jayakrishnan Harikrishnavilas Raveendran Nair, Michael Reimann, Ying Shi, Marwan Muhammad Ahmed Abdellah, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Adrien Christian Fleury, Michael Emiel Gevaert, Pramod Shivaji Kumbhar, Oren Amsalem, Cyrille Pierre Henri Favreau, Mohameth François Sy, Samuel Claude Kerrien, Elisabetta Iavarone, Christian O'Reilly, Genrich Ivaska, András Ecker, Anna-Kristin Kaufmann, Benoît Jean-Albert Coste, Ioannis Magkanaris, Matthias Wolf, Marine Laure Bertschy, Patrycja Lurie, Mustafa Anil Tuncel, Fabien Petitjean, Nadir Roman Guerrero, Liviu Soltuzu, Alexander Désiré Ulbrich, Polina Litvak, Vignayanandam Ravindernath Muddapu, Joni Henrikki Herttuainen

2023

Technology-Enabled Collaborative Care for Concurrent Diabetes and Distress Management During the COVID-19 Pandemic: Protocol for a Mixed Methods Feasibility Study

Sean Lewis Hill

Background: The COVID-19 pandemic disrupted the delivery of diabetes care and worsened mental health among many patients with type 2 diabetes (T2D). This disruption puts patients with T2D at risk for poor diabetes outcomes, especially those who experience ...

JMIR PUBLICATIONS, INC2023

Blue Brain Nexus: An open, secure, scalable system for knowledge graph management and data-driven science

Henry Markram, Henry Genet, Alejandra Garcia Rojas Martinez, Sean Lewis Hill, Huanxiang Lu, Mohameth François Sy, Samuel Claude Kerrien, Michaël Fernand Paul Dupont, Silvia Rosario Jimenez Tejeda, Bogdan Roman, Ian Lavriushev, Anna-Kristin Kaufmann, Didac Montero Mendez, Wojciech Adam Wajerowicz, Pierre-Alexandre Fonta, Kenneth William Pirman, Julien Antonin Machon, Jonathan Raël Lurie, Dhanesh Neela Mana, Natalia Stafeeva, Alexander Désiré Ulbrich, Carolina Johanna Elisabeth Lindqvist

Modern data-driven science often consists of iterative cycles of data discovery, acquisition, preparation, analysis, model building and validation leading to knowledge discovery as well as dissemination at scale. The unique challenges of building and simul ...

2023

The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types

Sean Lewis Hill, Mohameth François Sy

The challenge of defining and cataloging the building blocks of the brain requires a standardized approach to naming neurons and organizing knowledge about their properties. The US Brain Initiative Cell Census Network, Human Cell Atlas, Blue Brain Project, ...

HUMANA PRESS INC2022

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt, Steven Petrou

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

National Academy of Sciences2020

Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons

Henry Markram, Sean Lewis Hill, Ying Shi, Werner Alfons Hilda Van Geit, Jane Yi, Christian Andreas Rössert, Elisabetta Iavarone, Christian O'Reilly, Bas-Jan Zandt

Somatosensory thalamocortical (TC) neurons from the ventrobasal (VB) thalamus are central components in the flow of sensory information between the periphery and the cerebral cortex, and participate in the dynamic regulation of thalamocortical states inclu ...

2019

Reconstruction and simulation of neocortical microcircuitry

Henry Markram, Felix Schürmann, Sean Lewis Hill, Eilif Benjamin Muller

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for reconstructing and simulating neocortical microcircuitry. In one aspect, a method includes providing a model of neural tissue, the model including differ ...

2018

Towards a supervised classification of neocortical interneuron morphologies

Sean Lewis Hill, Ruth Benavides Piccione, Bojan Mihaljevic

BackgroundThe challenge of classifying cortical interneurons is yet to be solved. Data-driven classification into established morphological types may provide insight and practical value.ResultsWe trained models using 217 high-quality morphologies of rat so ...

2018

A Framework for Collaborative Curation of Neuroscientific Literature

Sean Lewis Hill, Elisabetta Iavarone, Christian O'Reilly

Large models of complex neuronal circuits require specifying numerous parameters, with values that often need to be extracted from the literature, a tedious and error-prone process. To help establishing shareable curated corpora of annotations, we have dev ...

Frontiers Research Foundation2017

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

Sean Lewis Hill, Deepak Gupta, William John Stewart

Elsevier2017

Comments and General Discussion on “The Anatomical Problem Posed by Brain Complexity and Size: A Potential Solution”

Sean Lewis Hill, Idan Segev

This article gathers together different opinions on the current status and future directions of the study of the brain, taking as a working document the article “The anatomical problem posed by brain complexity and size: a potential solution” http://journa ...

Frontiers Research Foundation2016

Data Publications Correlate with Citation Impact

Sean Lewis Hill

Neuroscience and molecular biology have been generating large datasets over the past years that are reshaping how research is being conducted. In their wake, open data sharing has been singled out as a major challenge for the future of research. We conduct ...

Frontiers Research Foundation2016

The Resource Identification Initiative: A cultural shift in publishing

Sean Lewis Hill

A central tenet in support of research reproducibility is the ability to uniquely identify research resources, i.e., reagents, tools, and materials that are used to perform experiments. However, current reporting practices for research resources are insuff ...

Wiley-Blackwell2016

Reconstructing the brain: from image stacks to neuron synthesis

Sean Lewis Hill, Julian Charles Shillcock

Large-scale brain initiatives such as the US BRAIN initiative and the European Human Brain Project aim to marshall a vast amount of data and tools for the purpose of furthering our understanding of brains. Fundamental to this goal is that neuronal morpholo ...

2016

Grand Challenges for Global Brain Sciences

Miguel Nicolelis, Corrado Cali, Sean Lewis Hill

The next grand challenges for society and science are in the brain sciences. A collection of 60+ scientists from around the world, together with 10+ observers from national, private, and foundations, spent two days together discussing the top challenges th ...

2016

How do we know what we know? Discovering neuroscience data sets through minimal metadata

Sean Lewis Hill

With the emergence of brain research initiatives around the world, the need for standards to facilitate neuroscience data sharing is growing. A crucial first step will be to establish a minimal metadata standard that allows the discovery of and access to s ...

2016

Structural to functional synaptic conversion

Henry Markram, Felix Schürmann, James Gonzalo King, Sean Lewis Hill, Eilif Benjamin Muller, Michael Reimann

Computer-implemented methods, software, and systems for determining functional synapses from given structural touches between cells in a neuronal circuit are described. One computer-implemented method for determining functional synapses from predetermined ...

Technology Transfer Office EPFL2015

Agile text mining with Sherlok

Jean-Cédric Chappelier, Sean Lewis Hill, Renaud Luc Richardet

The successful development of an intelligent text mining application requires the collaboration of two main stakeholders: subject matter experts and text miners. In this paper, we describe a new methodology, agile text mining to improve that collaboration. ...

IEEE2015

Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI)

Sean Lewis Hill

BACKGROUND: Current classification of traumatic brain injury (TBI) is suboptimal, and management is based on weak evidence, with little attempt to personalize treatment. A need exists for new precision medicine and stratified management approaches that inc ...

Lippincott, Williams & Wilkins2015