Publications by Katarzyna Pierzchala

Fast 3D 31P B1+ mapping with a weighted stack of spiral trajectory at 7 T

Lijing Xin, Katarzyna Pierzchala, Daniel Wenz, Mark Stephan Widmaier

Purpose: Phosphorus MRS (31P MRS) enables noninvasive assessment of energy metabolism, yet its application is hindered by sensitivity limitations. To overcome this, often high magnetic fields are used, leading to challenges such as spatial (Formula present ...

Wiley2025

Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Dunja Simicic, Jessie Julie Mosso

Introduction Type C hepatic encephalopathy (HE) is a decompensating event of chronic liver disease leading to severe motor and cognitive impairment. The progression of type C HE is associated with changes in brain metabolite concentrations measured by 1H m ...

Frontiers Media Sa2024

Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

Hepatic encephalopathy is a neuropsychiatric complication of liver disease which is partly associated with elevated ammonemia. Urea hydrolysis by urease-producing bacteria in the colon is often mentioned as one of the main routes of ammonia production in t ...

Nature Portfolio2024

Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons

Katarzyna Pierzchala

Adults and children with cholestatic liver disease are at risk for type C hepatic encephalopathy (HE) and may present lifelong neurocognitive impairment. While the underlying cellular and molecular mechanisms are still incompletely understood, ammonium and ...

Nature Portfolio2024

Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

Lippincott Williams & Wilkins2023

The Beneficial Effect of Oral Cr Supplementation in an Early Childhood Rat Model of Chronic Hepatic Encephalopathy: In Vivo Longitudinal 1H and 31P Magnetic Resonance Spectroscopy Study

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

Lippincott Williams & Wilkins2023

Central Nervous System Oxidative Stress interplay with inflammation in a rat model of Type C Hepatic Encephalopathy - brothers in arms?

Andrzej Sienkiewicz, Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

ELSEVIER SCIENCE INC2023

Evaluation of a Hydroxamate-Based Urease Inhibitor in a Rodent Model of Hepatic Encephalopathy

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

Lippincott Williams & Wilkins2023

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Jessie Julie Mosso

Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...

SPRINGER/PLENUM PUBLISHERS2023

SPARCQ: A new approach for fat fraction mapping using asymmetries in the phase-cycled balanced SSFP signal profile

Katarzyna Pierzchala, Tobias Kober, Tom Hilbert

Purpose: To develop SPARCQ (Signal Profile Asymmetries for Rapid Compartment Quantification), a novel approach to quantify fat fraction (FF) using asymmetries in the phase-cycled balanced SSFP (bSSFP) profile. ...

WILEY2023

Gd3+-Functionalized Lithium Niobate Nanoparticles for Dual Multiphoton and Magnetic Resonance Bioimaging

Sandrine Gerber, Anne-Sophie Chauvin, Luigi Bonacina, Marinella Mazzanti, Katarzyna Pierzchala, Raphaël Jovita De Matos, Dario Diviani, Jérémy Vuilleumier, Adrian Stefan Gheata, Ileana Ozana Jelescu, Laura Camille Louise Nicolle, Fiorella Lucarini

Harmonic nanoparticles (HNPs) have emerged as appealing exogenous probes for optical bioimaging due to their distinctive features such as long-term photostability and spectral flexibility, allowing multiphoton excitation in the classical (NIR-I) and extend ...

2022

Abnormal brain oxygen homeostasis in an animal model of liver disease

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Dunja Simicic

Background & Aims: Increased plasma ammonia concentration and consequent disruption of brain energy metabolism could underpin the pathogenesis of hepatic encephalopathy (HE). Brain energy homeostasis relies on effective maintenance of brain oxygenation, an ...

ELSEVIER2022

Central Nervous System Oxidative Stress Interplay With Inflammation In A Rat Model Of Type C Hepatic Encephalopathy - Brothers In Arms?

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

ELSEVIER SCIENCE INC2022

Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy

Andrzej Sienkiewicz, Rolf Gruetter, Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

The role and coexistence of oxidative stress (OS) and inflammation in type C hepatic encephalopathy (C HE) is a subject of intense debate. Under normal conditions the physiological levels of intracellular reactive oxygen species are controlled by the count ...

2022

Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy (vol 178, pg 295, 2022)

Andrzej Sienkiewicz, Rolf Gruetter, Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

ELSEVIER SCIENCE INC2022

Chromophore of an Enhanced Green Fluorescent Protein Can Play a Photoprotective Role Due to Photobleaching

László Forró, Andrzej Sienkiewicz, Katarzyna Pierzchala

Under stress conditions, elevated levels of cellular reactive oxygen species (ROS) may impair crucial cellular structures. To counteract the resulting oxidative damage, living cells are equipped with several defense mechanisms, including photoprotective fu ...

MDPI2021

Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE

Rolf Gruetter, Katarzyna Pierzchala, Cristina Ramona Cudalbu, Emmanuelle Ines Flatt

Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by chronic liver disease. Management of type C HE remains an important challenge because treatment options are limited. Both the antibiotic rifaximin and probiotics have been reported ...

Nature Portfolio2021

Synchronous nonmonotonic changes in functional connectivity and white matter integrity in a rat model of sporadic Alzheimer's disease

Bernard Lanz, Carole Poitry-Yamate, Katarzyna Pierzchala, Ileana Ozana Jelescu, Ting Yin, Yujian Diao

Brain glucose hypometabolism has been singled out as an important contributor and possibly main trigger to Alzheimer's disease (AD). Intracerebroventricular injections of streptozotocin (icv-STZ) cause brain glucose hypometabolism without systemic diabetes ...

2020

Thyrotropin-secreting pituitary adenomas: a systematic review and meta-analysis of postoperative outcomes and management

Katarzyna Pierzchala

PurposeTSH-secreting pituitary adenomas are rare pituitary tumors. An efficient treatment is essential to limit the mortality and morbidity in untreated patients. The aim of this study is to summarize the evidence about the postoperative outcomes and manag ...

SPRINGER2019

Residual hip dysplasia in children: osseous and cartilaginous acetabular angles to guide further treatment-a pilot study

Katarzyna Pierzchala

Purpose In case of residual hip dysplasia (RHD) in children, pelvic radiographs are sometimes insufficient to precisely evaluate the entire coverage of the femoral head, when trying to decide on the need for further reconstructive procedures. Methods This ...

2019