Publications by Guillaume Bonnier

Ultrahigh field in vivo characterization of microstructural abnormalities in the orbitofrontal cortex and amygdala in autism

Nouchine Hadjikhani, Guillaume Bonnier, Elda Fischi Gomez, Cristina Granziera

There are currently no biomarkers for autism spectrum disorder (ASD). This neurodevelopmental condition has previously been associated with histopathological findings, including increased neuronal packing density in the amygdala, abnormal laminar cytoarchi ...

2021

Evolution of Cortical and White Matter Lesion Load in Early-Stage Multiple Sclerosis: Correlation With Neuroaxonal Damage and Clinical Changes

Meritxell Bach Cuadra, Guillaume Bonnier, Cristina Granziera, Mario Joao Fartaria de Oliveira, Po-Jui Lu

Introduction:Changes in cortical and white matter lesion (CL, WML) load are pivotal metrics to diagnose and monitor multiple sclerosis patients. Yet, the relationship between (i) changes in CL/WML load and disease progression and between (ii) changes in CL ...

FRONTIERS MEDIA SA2020

Quantitative brain relaxation atlases for personalized detection and characterization of brain pathology

Jean-Philippe Thiran, Reto Meuli, Guillaume Bonnier, Tobias Kober, Cristina Granziera, Tom Hilbert, Gian Franco Piredda

Purpose To exploit the improved comparability and hardware independency of quantitative MRI, databases of MR physical parameters in healthy tissue are required, to which tissue properties of patients can be compared. In this work, normative values for long ...

WILEY2020

Personalized pathology maps to quantify diffuse and focal brain damage

Guillaume Bonnier, Tobias Kober, Elda Fischi Gomez, Cristina Granziera, Alexis Roche, Tom Hilbert

2019

Surface-based characteristics of the cerebellar cortex visualized with ultra-high field MRI

Guillaume Bonnier, Wietske Van der Zwaag, Gunnar Krüger, Yohan Boillat, Cristina Granziera, Kieran O'Brien, Mario Joao Fartaria de Oliveira

Although having a relatively homogeneous cytoarchitectonic organization, the cerebellar cortex is a heterogeneous region characterized by different amounts of myelin, iron and protein expression profiles. In this study, we used quantitative T1 and T2* mapp ...

2018

Automated assessment of new and enlarged white matter and cortical lesions in early multiple sclerosis

Meritxell Bach Cuadra, Guillaume Bonnier, Tobias Kober, Cristina Granziera, Mario Joao Fartaria de Oliveira

SAGE PUBLICATIONS LTD2018

An Ultra-High Field Study of Cerebellar Pathology in Early Relapsing-Remitting Multiple Sclerosis Using MP2RAGE

Meritxell Bach Cuadra, Guillaume Bonnier, Gunnar Krüger, Tobias Kober, Cristina Granziera, Alexis Roche, Kieran O'Brien, Pavel Falkovskiy, Mario Joao Fartaria de Oliveira

Objectives: The aim of this study was to study focal cerebellar pathology in early stages of multiple sclerosis (MS) using ultra-high-field magnetization-prepared 2 inversion-contrast rapid gradient-echo (7T MP2RAGE). Materials and Methods: Twenty early-st ...

Lippincott, Williams & Wilkins2017

Prospective head motion correction using FID-guided on-demand image navigators

Reto Meuli, Rolf Gruetter, Bénédicte Marie Maréchal, Guillaume Bonnier, Gunnar Krüger, Tobias Kober, Tom Hilbert, Maryna Volodimirivna Waszak, Pavel Falkovskiy

PURPOSE: We suggest a motion correction concept that employs free-induction-decay (FID) navigator signals to continuously monitor motion and to guide the acquisition of image navigators for prospective motion correction following motion detection. METHODS: ...

Wiley-Blackwell2017

Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis

Gloria Menegaz, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Guillaume Bonnier, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alexis Roche, Ying-Chia Lin

Introduction. Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based ...

Hindawi Publishing Corporation2015

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

Meritxell Bach Cuadra, Reto Meuli, Guillaume Bonnier, Daniel Andreas Schmitter, Cristina Granziera, Alessandro Daducci, Alexis Roche

Objectives: The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI). Methods: Forty-two MCI patients and 77 healthy co ...

Elsevier2015

Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing‐remitting multiple sclerosis

Jonas Richiardi, Gloria Menegaz, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Dimitri Nestor Alice Van De Ville, Guillaume Bonnier, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alessandro Daducci, Alexis Roche, Ying-Chia Lin

Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast “connectometry” approach to assess the structural and functional ...

Wiley-Blackwell2015

Prospective motion correction with FID-triggered image navigators

Jean-Philippe Thiran, Reto Meuli, Rolf Gruetter, Guillaume Bonnier, Gunnar Krüger, Tobias Kober, Tom Hilbert, Maryna Volodimirivna Waszak, Pavel Falkovskiy

2015

Multicontrats MRI Improved the Clinico-Radiological Correlation in Early Multiple Sclerosis Patients with Minor Deficits

Gloria Menegaz, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Guillaume Bonnier, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alexis Roche, Ying-Chia Lin

Conventional magnetic resonance imaging (MRI) of patients with multiple sclerosis provides only limited insights into the nature of brain tissue damage with modest clinical-radiological correlations. In this study, quantitative and semi-quantitative MRI te ...

2014

Cerebellar Connectomics Provide New Biomarkers in Early Multiple Sclerosis

Jonas Richiardi, Gloria Menegaz, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Dimitri Nestor Alice Van De Ville, Guillaume Bonnier, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alessandro Daducci, Alexis Roche, Ying-Chia Lin

The cerebellum is involved in multiple sclerosis (MS), but its implication in early phases is still poorly understood. We investigated structural and functional cerebellar connectivity alterations in early and minimally impaired MS patients, and their corr ...

2014

Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis

Gloria Menegaz, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Guillaume Bonnier, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alexis Roche, Ying-Chia Lin

In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-radiological correlation. In this study, we applied recent advances in MRI techniques ...

2014

Multiple Sclerosis Lesion Fingerprint Using Multicontrast MRI

Gloria Menegaz, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Guillaume Bonnier, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alexis Roche, Ying-Chia Lin

Conventional magnetic resonance imaging (MRI) measures of multiple sclerosis patients provide limited information about the nature and the extent of brain damage and repair. We established a clinically compatible protocol including quantitative MRI techniq ...

2014