Publications by Alessandra Griffa

Idiopathic normal pressure hydrocephalus: A sulcal morphometry approach to brain phenotype and clinical response

Dimitri Nestor Alice Van De Ville, Alessandra Griffa

Idiopathic normal pressure hydrocephalus (iNPH), the leading cause of reversible dementia in older adults, is characterized by urinary incontinence, gait impairment, cognitive decline, and ventriculomegaly. Neuroradiological features rely on visual assessm ...

Elsevier BV2025

The complementary role of automated brain volumetry to stratify ADNI participants within the ATN framework

Bénédicte Marie Maréchal, Alessandra Griffa, Ricardo Alberto Corredor Jerez, Ilaria Ricchi

The amyloid, tau, neurodegeneration (ATN) framework provides a biological staging model of Alzheimer's disease (AD) using magnetic resonance imaging (MRI), cerebrospinal fluid (CSF), or positron emission tomography (PET) biomarkers. MRI, being non-invasive ...

SAGE Publications2025

Longitudinal changes in MEG-based brain network topology of ALS patients with cognitive/behavioral impairment—An exploratory study

Alessandra Griffa

Amyotrophic lateral sclerosis (ALS) with only motor impairment (ALS-pure motor) and the behavioral variant of frontotemporal dementia (bvFTD) are hypothesized to represent extreme ends of a disease spectrum, which encompasses ALS with cognitive/behavioral ...

MIT Press2025

Amnestic Syndrome in Memory Clinics: Similar Morphological Brain Patterns in Older Adults with and without Alzheimer’s Disease (P4-3.006)

Bénédicte Marie Maréchal, Alessandra Griffa

Ovid Technologies (Wolters Kluwer Health)2025

Functional dynamic network connectivity differentiates biological patterns in the Alzheimer's disease continuum

Alessandra Griffa

Alzheimer's disease (AD) can be conceptualized as a network-based syndrome. Network alterations are linked to the molecular hallmarks of AD, involving amyloid-beta and tau accumulation, and consecutively neurodegeneration. By combining molecular and restin ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2025

Sex differences in the association of Alzheimer's disease biomarkers and cognition in a multicenter memory clinic study

Alessandra Griffa

Background This study investigated sex differences in the associations between Alzheimer's disease (AD) biomarkers, cognitive performance, and decline in memory clinic settings. Methods 249 participants (females/males:123/126), who underwent tau-PET, amylo ...

BMC2025

A thousand ways to tailor your tractography-based connectome

Alessandra Griffa

Did you know that there are thousands of ways to build a connectome from diffusion MRI tractography, and the choice of approach can hugely impact the final connectome and results? To name only a few: Tractography type: deterministic or probabilistic? Parce ...

2025

Biomarkers do not paint the whole picture: The role of clinical expertise and advanced neuroimaging for Alzheimer's disease diagnosis

Alessandra Griffa

Accurate diagnosis of Alzheimer's disease (AD) in Memory Clinics remains challenging due to the limited specificity of conventional clinical assessment and structural imaging. The recent commentary by Vyhnalek and colleagues advocates for the incorporation ...

SAGE PUBLICATIONS LTD2025

Cerebral amyloid angiopathy in patients with Dementia with Lewy Bodies: A clinical and hippocampal morphology study

Olaf Blanke, Alessandra Griffa

Introduction: Dementia with Lewy Bodies (DLB) is often associated with Cerebral Amyloid Angiopathy (CAA) based on pathological studies. Current literature in DLB reveals heterogenous findings regarding CAA effects on cognition, but overall suggests a diffu ...

2025

Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?

Alessandra Griffa

The preclinical phase of Alzheimer’s disease represents a crucial time window for therapeutic intervention but requires the identification of clinically relevant biomarkers that are sensitive to the effects of disease-modifying drugs. Amyloid peptide and t ...

2025

Connectome embedding in multidimensional graph spaces

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Enrico Amico, Maria Giulia Preti, Raphaël Pierre Liégeois

Nodal properties are of particular importance when investigating patterns in brain networks. Nodal information is usually studied by comparing a few nodal measurements (up to three), resulting in analyses in three-dimensional spaces, at maximum. We offer a ...

MIT PRESS2024

Cerebral amyloid angiopathy differently impacts gray matter microstructure in patients with Lewy bodies dementia and Alzheimer’s disease

Alessandra Griffa

Cerebral amyloid angiopathy (CAA) has been reported in patients with dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD), with a similar prevalence from pathology studies. 1,2 CAA typically affects posterior regions, but amyloid deposits have been ...

Wiley2024

Amnestic Syndrome in Memory Clinics: Similar Morphological Brain Patterns in Older Adults with and without Alzheimer's Disease

Bénédicte Marie Maréchal, Alessandra Griffa

Background: Amnestic syndrome of the hippocampal type (ASHT) in Memory Clinics is a presentation common to Alzheimer's disease (AD). However, ASHT can be found in other neurodegenerative disorders. Objective: To compare brain morphometry including hippocam ...

IOS PRESS2024

Rebalance the Inhibitory System in the Elderly Brain: Influence of Balance Learning on GABAergic Inhibition and Functional Connectivity

Lijing Xin, Alessandra Griffa, Songi Lim

Aging involves complex processes that impact the structure, function, and metabolism of the human brain. Declines in both structural and functional integrity along with reduced local inhibitory tone in the motor areas, as indicated by reduced γ-aminobutyri ...

Wiley2024

Acute TNF alpha levels predict cognitive impairment 6-9 months after COVID-19 infection

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Alexandre Cionca, Idris Guessous

Background: A neurocognitive phenotype of post-COVID-19 infection has recently been described that is characterized by a lack of awareness of memory impairment (i.e., anosognosia), altered functional connectivity in the brain's default mode and limbic netw ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Acute TNF alpha levels predict cognitive impairment 6-9 months after COVID-19 infection (vol 153, 106104, 2023)

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Alexandre Cionca, Idris Guessous

PERGAMON-ELSEVIER SCIENCE LTD2023

Task matters: Individual MEG signatures from naturalistic and neurophysiological brain states

Alessandra Griffa, Enrico Amico, Ekansh Sareen

The discovery that human brain connectivity data can be used as a "fingerprint " to identify a given individual from a population, has become a burgeoning research area in the neuroscience field. Recent studies have iden-tified the possibility to extract t ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

Markers of limbic system damage following SARS-CoV-2 infection

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Alexandre Cionca, Idris Guessous

Alterations of the limbic system may be present in the chronic phase of SARS-CoV-2 infection. Our aim was to study the long-term impact of this disease on limbic system-related behaviour and its associated brain functional connectivity, according to the se ...

OXFORD UNIV PRESS2023

Evidence for increased parallel information transmission in human brain networks compared to macaques and male mice

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Enrico Amico

Brain communication, defined as information transmission through white-matter connections, is at the foundation of the brain's computational capacities that subtend almost all aspects of behavior: from sensory perception shared across mammalian species, to ...

Nature Portfolio2023

Brain functional connectivity alterations associated with neuropsychological performance 6-9 months following SARS-CoV-2 infection

Dimitri Nestor Alice Van De Ville, Alessandra Griffa

Neuropsychological deficits and brain damage following SARS-CoV-2 infection are not well understood. Then, 116 patients, with either severe, moderate, or mild disease in the acute phase underwent neuropsychological and olfactory tests, as well as completed ...

Wiley2023