Publications by Priscilla Suhasna Maithili Briquez

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling

Jeffrey Alan Hubbell, Melody Swartz, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Esra Güç, Manuel Andreas Fankhauser

Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growt ...

2017

Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials

Jeffrey Alan Hubbell, Peter Frey, Kristen Lorentz, Priscilla Suhasna Maithili Briquez, Hans Mattias Larsson

Aprotinin is a broad-spectrum serine protease inhibitor used in the clinic as an anti-fibrinolytic agent in fibrin-based tissue sealants. However, upon re-exposure, some patients suffer from hypersensitivity immune reactions likely related to the bovine or ...

2017

Engineering growth factors for regenerative medicine applications

Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Growth factors are important morphogenetic proteins that instruct cell behavior and guide tissue repair and renewal. Although their therapeutic potential holds great promise in regenerative medicine applications, translation of growth factors into clinical ...

Elsevier Sci Ltd2016

IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering

Jeffrey Alan Hubbell, Peter Frey, Priscilla Suhasna Maithili Briquez, Hans Mattias Larsson, Elif Vardar, Kalitha Pinnagoda

Clinical success of bladder reconstructive procedures could be promoted by the availability of functional biomaterials. In this study, we have developed a multi-layered scaffold consisting of a bioactive fibrin layer laminated between two collagen sheets a ...

Elsevier Sci Ltd2016

Design principles for therapeutic angiogenic materials

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and therapeutic angiogenesis, which has potential in the treatment of various cardiovascular diseases, remains a major challenge. Physiologically, angiogenesis - the proc ...

Nature Publishing Group2016

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

Priscilla Suhasna Maithili Briquez

Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...

EPFL2016

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Significance: Growth factors are very promising molecules for the treatment of skin wounds. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems may derive from the fa ...

Mary Ann Liebert, Inc2015

Extracellular matrix-inspired growth factor delivery systems for bone regeneration

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiologic ...

Elsevier Science Bv2015

Conjugates containing sequences from placenta growth factor and their use as components of biomaterials and in medicine

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Embodiments of the invention are described, including materials and methods for making molecules and materials that have a specific binding domain of a P1GF2. Embodiments include, for instance, medicaments, biomaterials, biomolecules, molecular fusions, an ...

2015

Engineering Interactions between Morphogens and the Extracellular Matrix

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Mary Ann Liebert, Inc2015

Engineering Interactions between Growth Factors and the Extracellular Matrix

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Esra Güç

Federation Amer Soc Exp Biol2015

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Stéphanie Elisabeth Metzger, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Jeffrey James Rice, Esra Güç, Federico Tortelli

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...

American Association for the Advancement of Science2014

Growth factors engineered for super-affinity to extracellular matrix enhance tissue healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Federico Tortelli

Wiley-Blackwell2014

Extracellular matrix molecules regulate growth factor and cytokine delivery through their heparin-binding domains and promote wound healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Marco Pisano, Federico Tortelli

Wiley-Blackwell2014

Fibronectin Binding Modulates CXCL11 Activity and Facilitates Wound Healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Marco Pisano, Federico Tortelli

Engineered biomatrices offer the potential to recapitulate the regenerative microenvironment, with important implications in tissue repair. In this context, investigation of the molecular interactions occurring between growth factors, cytokines and extrace ...

Public Library of Science2013

Engineering the Regenerative Microenvironment with Biomaterials

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Jeffrey James Rice, Federico Tortelli

Modern synthetic biomaterials are being designed to integrate bioactive ligands within hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced biomaterials are only beginning to be used to simulate the complex spatio-tempor ...

Wiley-Blackwell2013

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

Matthias Lütolf, Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Adrian Ranga

By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM d ...

National Academy of Sciences2013