Charlotte Marie Urech-Varenne

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Related publications (4)

Direct targeting of NOTCH transcription complex by a novel small molecule CB-103 circumvents dose-limiting toxicities associated with pan-NOTCH inhibitors

Freddy Radtke, Charlotte Marie Urech-Varenne, Rajwinder Lehal, Maximilien Murone, Michele Vigolo, Jelena Zaric

AMER ASSOC CANCER RESEARCH2019

Characterization and profiling of CB-103, a novel small-molecule protein-protein interaction inhibitor targeting the NOTCH transcription complex

Freddy Radtke, Charlotte Marie Urech-Varenne, Rajwinder Lehal, Maximilien Murone, Michele Vigolo

AMER ASSOC CANCER RESEARCH2018

Phage Selection of Bicyclic Peptides and High-Throughput Screening of Chemical Compounds for the Identification of Novel Inhibitors of the Notch Pathway

Charlotte Marie Urech-Varenne

Notch signaling is a highly conserved developmental pathway that plays important roles in the regulation of cellular processes including cell fate decisions and stem cell maintenance. A tight regulation of the Notch cascade ensures proper tissue homeostasi ...

EPFL2015

Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor

Christian Heinis, Freddy Radtke, Charlotte Marie Urech-Varenne

Precise regulation of the Notch signaling pathway is crucial, as increases or deficiencies in signaling are associated with diseases, including a wide range of cancers. Recent studies have demonstrated that monoclonal antibodies that bind and stabilize the ...

Wiley-Blackwell2015

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