Publications by Andrea Cavallini

Multiplexed nanoplasmonic biosensor for one-step simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine

Andrea Cavallini, Hatice Altug, Alexander Belushkin, Maria Soler Aznar

Development of rapid and multiplexed diagnostic tools is a top priority to address the current epidemic problem of sexually transmitted diseases. Here we introduce a novel nanoplasmonic biosensor for simultaneous detection of the two most common bacterial ...

2017

In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism

Catherine Dehollain, Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Francesca Stradolini

This paper presents the in-vivo tests on a Fully Implantable Multi-Panel Devices for Remote Monitoring of endogenous and exogenous analytes. To investigate issues on biocompatibility, three different covers have been designed, realized and tested in ...

Ieee-Inst Electrical Electronics Engineers Inc2016

Biocompatible Packagings for Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism

Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Camilla Baj-Rossi, Francesco Grassi

This paper compares three different biocompatible packagings suitable to support full implantation of multi-panel sensors for remote monitoring of metabolism. The three packagings have been designed, realized and implanted in mice for 30 days. ATP and neut ...

2015

A Subcutaneous Biochip for Remote Monitoring of Human Metabolism: Packaging and Biocompatibility Assessment

Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Jacopo Olivo, Seyedeh Sara Ghoreishizadeh

This paper represents the extended version of the conference paper “Developing highly-integrated subcutaneous biochips for remote monitoring of human metabolism” pre- sented at the IEEE Sensors Conference 2012, and presents data on assembly, packaging and ...

Institute of Electrical and Electronics Engineers2015

High-Performance Multipanel Biosensors Based on a Selective Integration of Nanographite Petals

László Forró, Arnaud Magrez, Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Irene Taurino, Federico Matteini

We report the first selective growth of nanographite petals and various carbon nanomaterials onto a multipanel electrochemical platform. Different types of nanomaterials can be obtained by fine-tuning the growth parameters of the chemical vapor deposition ...

Amer Chemical Soc2014

An Integrated Control and Readout Circuit for Implantable Multi-Target Electrochemical Biosensing

Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh

We describe an integrated biosensor capable of sensing multiple molecular targets using both cyclic voltammetry (CV) and chronoamperometry (CA). In particular, we present our custom IC to realize voltage control and current readout of the bio ...

2014

Continuous monitoring of Naproxen by a cytochrome P450-based electrochemical sensor

Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Camilla Baj-Rossi

This paper reports the characterization of an electrochemical biosensor for the continuous monitoring of Naproxen based on cytochrome P450. The electrochemical biosensor is based on the drop-casting of multi-walled carbon-nanotubes (MWCNTs) and microsomal ...

Elsevier2014

An implantable biosensor array for personalized therapy applications

Andrea Cavallini

At present, most of the tests involved in personalized medicine are complex and must be conducted in specialized centers. The development of appropriate, fast and inexpensive diagnostic technologies can encourage medical personnel in performing preventive ...

EPFL2013

Remote System for Monitoring Animal Models With Single-Metabolite Bio-Nano-Sensors

Léandre Bolomey, Eric Meurville, Giovanni De Micheli, Cristina Boero, Andrea Cavallini, Sandro Carrara

A novel system for remote monitoring of metabolism in an animal model is proposed in this paper. The system is obtained by integrating bio-nano-sensors to detect single- metabolites, an electrochemical front-end made with off-the-shelf components, a radio ...

Institute of Electrical and Electronics Engineers2013

Fully Integrated Biochip Platforms for Advanced Healthcare

Catherine Dehollain, Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Jacopo Olivo, Irene Taurino, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Wayne Burleson

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring ...

Mdpi Ag2012

Design, fabrication, and test of a sensor array for perspective biosensing in chronic pathologies

Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh

Biosensing for chronic pathologies requires the simultaneous monitoring of different parameters such as drug concentrations, inflammation status, temperature and pH. In this paper we discuss the design, fabrication and test of a sensor array hosting five b ...

2012

Comparison of Three Methods of Biocompatible Multi-Walled Carbon Nanotubes Confinement for the Development of Implantable Amperometric Adenosine-5′-Triphosphate Biosensors

Giovanni De Micheli, Andrea Cavallini, Sandro Carrara

An amperometric biosensor for adenosine 5 -triphosphate (ATP) was developed applying a competitive assay of two glucose converting enzymes: glucose oxidase (GOD) and hexokinase (HEX). Competition between GOD and HEX for glucose in presence of ATP, lead to ...

American Scientific Publishers2011

A new ethylene glycol-silane monolayer for highly-specific DNA detection on Silicon Chips

Edoardo Charbon, Giovanni De Micheli, Andrea Cavallini, Sandro Carrara

Monolayer thin films with ethylene-glycol function onto gold surfaces by using thiols have been extensively investigated. They have been proposed as precursors for applications to bio-detection, where their hydrophilic character improves both specificity a ...

Emerald2010

New probe immobilizations by lipoate-diethalonamine or ethylene-glycol molecules for capacitance DNA chip

Yusuf Leblebici, Giovanni De Micheli, Bruno Samori, Luca Benini, Andrea Cavallini, Sandro Carrara

Label–free DNA detection is of crucial role to when developing point-of-care biochips to be used in personalized therapy. Capacitance detection is a promising technology for label-free DNA detection. However, data published in literature often show evident ...

2009

New insights for using self-assembly materials to improve the detection stability in label-free DNA-chip and immuno-sensors

Bruno Samori, Luca Benini, Andrea Cavallini, Sandro Carrara, Anna Ferretti

This paper examines reliable advancements in low-cost DNA- and immuno-chips. Capacitance detection was successfully chosen to develop label-free bio-chips. Probe immobilization was rigorously investigated in order to obtain reliable capacitance measurement ...

Elsevier2009

Dynamical Spot Queries to Improve Specificity in P450s based Multi-Drugs Monitoring

Abhishek Garg, Giovanni De Micheli, Andrea Cavallini, Sandro Carrara

Personalized therapy requires accurate and frequent monitoring of drugs metabolic response in living organisms during drug treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecules cocktails, direct monitoring of ...

2009

3D Architecture and Replaceable Layers for Label-Free DNA Biochips

Yusuf Leblebici, Andrea Cavallini, Yüksel Temiz, Sandro Carrara

Recent advances in bio-sensing technologies have led to design of bio-sensor arrays for rapid identification and quantification of various biological agents such as drugs, gene expressions, proteins, cholesterol, fats, etc. Various dedicated sensing arrays ...

2009

Circuits Design and Nano-Structured Electrodes for Drugs Monitoring in Personalized Therapy

Giovanni De Micheli, Luca Benini, Andrea Cavallini, Sandro Carrara, Jacopo Olivo

Drug development and personalized therapy require accurate and frequent monitoring of the metabolic response by living tissues to treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecule cocktails, direct monitori ...

IEEE2008

Condensation of Zeotropic Mixtures in Horizontal Tubes: New Simplified Heat Transfer Model Based on Flow Regimes

John Richard Thome, Andrea Cavallini

2005