Publications by Joan Goulley | EPFL Graph Search

Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging

Theo Lasser, Martin Villiger, Anne Grapin-Botton, Corinne Berclaz, Joan Goulley, Arno Pino Bouwens, Daniel Pawel Szlag, Jérôme Extermann

Aims/hypothesis It is generally accepted that structural and functional quantitative imaging of individual islets would be beneficial to elucidate the pathogenesis of type 1 diabetes. We here introduce functional optical coherence imaging (FOCI) for fast, ...

Springer Verlag2016

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

Daniel Constam, Anne Grapin-Botton, Joan Goulley, Laurence Anne E Lemaire, Jacques Rougemont, Yung Hae Kim

In human, mutations in bicaudal C1 (BICC1), an RNA binding protein, have been identified in patients with kidney dysplasia. Deletion of Bicc1 in mouse leads to left-right asymmetry randomization and renal cysts. Here, we show that BICC1 is also expressed i ...

Company Of Biologists Ltd2015

Fast three-dimensional imaging of gold nanoparticles in living cells with photothermal optical lock-in Optical Coherence Microscopy

Christian Santschi, Theo Lasser, Martin Villiger, Corinne Berclaz, Christophe Pache, Matthew Gibson, Joan Goulley, Noelia Laura Bocchio, Arno Pino Bouwens

We introduce photothermal optical lock-in Optical Coherence Microscopy (poli-OCM), a volumetric imaging technique, which combines the depth sectioning of OCM with the high sensitivity of photothermal microscopy while maintaining the fast acquisition speed ...

Optical Society of America2012

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Anthony Christopher Davison, Theo Lasser, Martin Villiger, Dimitri Nestor Alice Van De Ville, Anne Grapin-Botton, Corinne Berclaz, Joan Goulley, Erica Martin-Williams, Arno Pino Bouwens

Diabetes is characterized by hyperglycemia that can result from the loss of pancreatic insulin secreting β-cells in the islets of Langerhans. We analyzed ex vivo the entire gastric and duodenal lobes of a murine pancreas using extended-focus Optical Cohere ...

2012

Towards high resolution optical imaging of beta cells in vivo

Theo Lasser, Martin Villiger, Anne Grapin-Botton, Joan Goulley, Erica Martin-Williams

Endocrine beta cells produce and release insulin in order to tightly regulate glucose homeostasis and prevent metabolic pathologies such as Diabetes Mellitus. Optical imaging has contributed greatly to our current understanding of beta cell structure and f ...

Bentham Science Publishers2010

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Theo Lasser, Martin Villiger, Michael Friedrich, Rainer Leitgeb, Anne Grapin-Botton, Joan Goulley

Aims/hypothesis Structural and functional imaging of the islets of Langerhans and the insulin-secreting beta cells represents a significant challenge and a long-lasting objective in diabetes research. In vivo microscopy offers a valuable insight into beta ...

Springer Verlag2009