Publications by Stewart Cole | EPFL Graph Search

An analysis of parameter compression and Full-Modeling techniques with Velocileptors for DESI 2024 and beyond

Eduardo Sanchez, Hua Zhang, Stewart Cole

In anticipation of forthcoming data releases of current and future spectroscopic surveys, we present the validation tests and analysis of systematic effects within velocileptors modeling pipeline when fitting mock data from the AbacusSummit N-body simulati ...

IOP Publishing Ltd2025

Validation of the Scientific Program for the Dark Energy Spectroscopic Instrument

Eduardo Sanchez, Zhifeng Ding, Sun Hee Kim, Hua Zhang, Stewart Cole, Jiangyan Yang, Jean-Paul Richard Kneib, Anand Stéphane Raichoor, Andrei Variu, Ting Tan, Daniel Felipe Forero Sanchez, Cheng Zhao, Arjun Dey, David Schlegel, Zheng Zheng, Xin Chen

The Dark Energy Spectroscopic Instrument (DESI) was designed to conduct a survey covering 14,000 deg(2) over 5 yr to constrain the cosmic expansion history through precise measurements of baryon acoustic oscillations (BAO). The scientific program for DESI ...

Iop Publishing Ltd2024

Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis

Stewart Cole, Anthony Vocat

Thiopeptides are ribosomally biosynthesized and post-translationally modified peptides (RiPPs) that potently inhibit the growth of Gram-positive bacteria by targeting multiple steps in protein biosynthesis. The poor pharmacological properties of thiopeptid ...

2024

The DESI Survey Validation: Results from Visual Inspection of Bright Galaxies, Luminous Red Galaxies, and Emission-line Galaxies

Stewart Cole, Yi Zhang, Anand Stéphane Raichoor, Jiaxi Yu, Arjun Dey

The Dark Energy Spectroscopic Instrument (DESI) Survey has obtained a set of spectroscopic measurements of galaxies to validate the final survey design and target selections. To assist in these tasks, we visually inspect DESI spectra of approximately 2500 ...

IOP Publishing Ltd2023

Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway

Stewart Cole, Anthony Vocat

3,5-Dinitrobenzylsulfanyl tetrazoles and 1,3,4-oxadiazoles, previously identified as having high in vitro activities against both replicating and nonreplicating mycobacteria and favorable cytotoxicity and genotoxicity profiles were investigated. First we d ...

Amer Chemical Soc2023

Gene expression patterns associated with multidrug therapy in multibacillary leprosy

Stewart Cole, Philippe Busso, Andrej Benjak, Charlotte Avanzi, Thyago Leal Calvo

Multidrug therapy (MDT) has been successfully used in the treatment of leprosy. However, although patients are cured after the completion of MDT, leprosy reactions, permanent disability, and occasional relapse/reinfection are frequently observed in patient ...

FRONTIERS MEDIA SA2022

Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis

Stewart Cole, Charlotte Avanzi, Thyago Leal Calvo

Author summaryLeprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae, an obligate intracellular bacterium. Diagnosis of leprosy often relies on skin examinations for clinical signs, bacilli staining from skin smears and invasive s ...

PUBLIC LIBRARY SCIENCE2022

Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2)

Stewart Cole, Anthony Vocat

Type II NADH dehydrogenase (NDH-2) is an essential component of electron transfer in many microbial pathogens but has remained largely unexplored as a potential drug target. Previously, quinolinyl pyrimidines were shown to inhibit Mycobacterium tuberculosi ...

AMER CHEMICAL SOC2022

Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine

Stewart Cole, Anthony Vocat

Tuberculosis, and especially multidrug-resistant tuberculosis (MDR-TB), is a major global health threat which emphasizes the need to develop new agents to improve and shorten treatment of this difficult-to-manage in-fectious disease. Among the new agents, ...

ELSEVIER2022

A new paradigm for leprosy diagnosis based on host gene expression

Stewart Cole, Philippe Busso, Andrej Benjak, Charlotte Avanzi, Thyago Leal Calvo

Author summary ...

PUBLIC LIBRARY SCIENCE2021

Design and Synthesis of Pyrano[3,2-b]indolones Showing Antimycobacterial Activity

Stewart Cole, Anthony Vocat

Latent Mycobacterium tuberculosis infection presents one of the largest challenges for tuberculosis control and novel antimycobacterial drug development. A series of pyrano[3,2-b]indolone-based compounds was designed and synthesized via an original eight-s ...

AMER CHEMICAL SOC2021

Leprosy in wild chimpanzees

Stewart Cole, Philippe Busso, Charlotte Avanzi

Humans are considered as the main host for Mycobacterium leprae(1), the aetiological agent of leprosy, but spillover has occurred to other mammals that are now maintenance hosts, such as nine-banded armadillos and red squirrels(2,3). Although naturally acq ...

NATURE PORTFOLIO2021

Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes

Stewart Cole, Philippe Busso, Charlotte Avanzi

Background Hansen's disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins ...

BMC2021

Structural and DNA binding properties of mycobacterial integration host factor mIHF

Giovanni Dietler, Stewart Cole, Aleksandre Japaridze, Rajkumar Singh, Luciano Andres Abriata, Nina Theres Odermatt, Jérémie Piton, David Lyndon Emsley, Moreno Lelli

In bacteria, nucleoid associated proteins (NAPs) take part in active chromosome organization by supercoil management, three-dimensional DNA looping and direct transcriptional control. Mycobacterial integration host factor (mIHF, rv1388) is a NAP restricted ...

Elsevier2020

Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment

Stewart Cole, Philippe Busso, Andrej Benjak, Charlotte Avanzi

A case of Mycobacterium leprae rifampin resistance after irregular antile- prosy treatments since 1971 is reported. Whole-genome sequencing from four longi- tudinal samples indicated relapse due to acquired rifampin resistance and not to re- infection with ...

AMER SOC MICROBIOLOGY2020

Advanced Quantification Methods To Improve the 18b Dormancy Model for Assessing the Activity of Tuberculosis Drugs In Vitro

Stewart Cole, Claudia Sala

One of the reasons for the lengthy tuberculosis (TB) treatment is the difficulty to treat the nonmultiplying mycobacterial subpopulation. In order to assess the ability of (new) TB drugs to target this subpopulation, we need to incorporate dormancy models ...

AMER SOC MICROBIOLOGY2020

6,11-Dioxobenzo[f]pyrido[1,2-a]indoles Kill Mycobacterium tuberculosis by Targeting Iron-Sulfur Protein Rv0338c (IspQ), A Putative Redox Sensor

Kai Johnsson, Stewart Cole, Monica Rengifo Gonzalez, Edina Rita Székely, Andrej Benjak, Jérémie Piton

Screening of a diversity-oriented compound library led to the identification of two 6,11-dioxobenzo[f]pyrido[1,2-a]indoles (DBPI) that displayed low micromolar bactericidal activity against the Erdman strain of Mycobacterium tuberculosis in vitro. The acti ...

AMER CHEMICAL SOC2020

Synthesis and Structure-Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin

Stewart Cole, Ruben Hartkoorn, Anthony Vocat

A series of derivatives of the antimycobacterial natural product pyridomycin have been prepared with the C2 side chain attached to the macrocyclic core structure by a C-C single bond, in place of the synthetically more demanding enol ester double bond foun ...

AMER CHEMICAL SOC2020

High resolution CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis

Stewart Cole, Florence Pojer, Jérémie Piton

The EspB protein of Mycobacterium tuberculosis is a 60 kDa virulence factor, implicated in conjugation and exported by the ESX-1 system of which it may also be a component. Previous attempts to obtain high-resolution maps of EspB by cryo-electron microscop ...

2020

FasR Regulates Fatty Acid Biosynthesis and Is Essential for Virulence of Mycobacterium tuberculosis

Stewart Cole, Claudia Sala

Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is the world's leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition of the cell envelope, which adap ...

Frontiers Media SA2020