Publications by Jean Philippe Boquete

A humoral stress response protects Drosophila tissues from antimicrobial peptides

Jean Philippe Boquete, Bruno Lemaitre, Matteo Dal Peraro, Alexia Laurie Carboni, Samuel Rommelaere, Chan Cao, Fernando Augusto Teixeira Pinto Meireles

An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host ...

Elsevier BV2024

Disproportionate investment in Spiralin B production limits in-host growth and favors the vertical transmission of Spiroplasma insect endosymbionts

Jean Philippe Boquete, Bruno Lemaitre, Fanny Schüpfer, Samuel Rommelaere, Florent François Masson

Insects frequently harbor endosymbionts, which are bacteria housed within host tissues. These associations are stably maintained over evolutionary timescales through vertical transmission of endosymbionts from host mothers to their offspring. Some endosymb ...

National Academy of Sciences2022

Steroid‐dependent switch of OvoL/Shavenbaby controls self‐renewal versus differentiation of intestinal stem cells

Jean Philippe Boquete, Bruno Lemaitre, Dani Osman

Adult stem cells must continuously fine‐tune their behavior to regenerate damaged organs and avoid tumors. While several signaling pathways are well known to regulate somatic stem cells, the underlying mechanisms remain largely unexplored. Here, we demonst ...

Springer Science and Business Media LLC2020

The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila

Jean Philippe Boquete, Bruno Lemaitre, Jan Paul Dudzic, Elodie Julie Virginie Ramond, Bianca Marie Petrignani

In animals, growth is regulated by the complex interplay between paracrine and endocrine signals. When food is scarce, tissues compete for nutrients, leading to critical resource allocation and prioritization. Little is known about how the immune system ma ...

WILEY2020

Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster

Jean Philippe Boquete, Bruno Lemaitre, Jasquelin Peña, Igor Iatsenko, Alice Marra

Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by iron-binding proteins called transferrins. Despite many studies on antimicrobial activity of transferrins in vitro, their specific in vivo functions are poorl ...

National Academy of Sciences2020

The Exchangeable Apolipoprotein Nplp2 Sustains Lipid Flow and Heat Acclimation in Drosophila

Jean Philippe Boquete, Bruno Lemaitre, Jérémie Piton, Samuel Rommelaere

In ectotherms, increased ambient temperature requires the organism to consume substantial amounts of energy to sustain a higher metabolic rate, prevent cellular damage, and respond to heat stress. Here, we identify a heat-inducible apolipoprotein required ...

2019

Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

Jean Philippe Boquete, Bruno Lemaitre, Zongzhao Zhai

Intestinal infection triggers potent immune responses to combat pathogens and concomitantly drives epithelial renewal to maintain barrier integrity. Current models propose that epithelial renewal is primarily driven by damage caused by reactive oxygen spec ...

2018

Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

Jean Philippe Boquete, Bruno Lemaitre, Igor Iatsenko

Commensal microbes colonize the gut epithelia of virtually all animals and provide several benefits to their hosts. Changes in commensal populations can lead to dysbiosis, which is associated with numerous pathologies and decreased lifespan. Peptidoglycan ...

2018

A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila

Jean Philippe Boquete, Bruno Lemaitre, Zongzhao Zhai

The speed of stem cell differentiation has to be properly coupled with self-renewal, both under basal conditions for tissue maintenance and during regeneration for tissue repair. Using the Drosophila midgut model, we analyze at the cellular and molecular l ...

2017

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Jean Philippe Boquete, Bruno Lemaitre, Sveta Chakrabarti, Esther Jeanne Collas, Jan Paul Dudzic, Xiaoxue Li

The JAK/STAT pathway is a key signaling pathway in the regulation of development and immunity in metazoans. In contrast to the multiple combinatorial JAK/STAT pathways in mammals, only one canonical JAK/STAT pathway exists in Drosophila. It is activated by ...

Public Library of Science2016

Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis

Jean Philippe Boquete, Bruno Lemaitre, Zongzhao Zhai

Stem cell self-renewal and differentiation are coordinated to maintain tissue homeostasis and prevent cancer. Mutations causing stem cell proliferation are traditionally the focus of cancer studies. However, the contribution of the differentiating stem cel ...

Nature Publishing Group2015

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

Jean Philippe Boquete, Bruno Lemaitre, Bart Deplancke, Dani Osman

Although the gut is a central organ of Eumetazoans and is essential for organismal health, our understanding of its morphological and molecular determinants remains rudimentary. Here, we provide a comprehensive atlas of Drosophila adult midgut. Specificall ...

Elsevier2013