Publications by Alexis Rapin | EPFL Graph Search

Cyclo(His-Pro): A further step in the management of steatohepatitis

Alexis Rapin, Johan Auwerx, Adrienne Joëlle Laurence Mottis, Xiaoxu Li, Alessia De Masi, Qi Wang

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) have become the world's most common liver diseases, placing a growing strain on healthcare systems worldwide. Nonetheless, no effective pharmacological treatment has be ...

ELSEVIER2023

The skin microbiome in the first year of life and its association with atopic dermatitis

Alexis Rapin

BackgroundEarly-life microbial colonization of the skin may modulate the immune system and impact the development of atopic dermatitis (AD) and allergic diseases later in life. To address this question, we assessed the association between the skin microbio ...

WILEY2023

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Alexis Rapin, Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Jean-David Horacio Morel, Xiaoxu Li

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

Elena Katsyuba, Alexis Rapin, Johan Auwerx, Nicola Harris, Adrienne Joëlle Laurence Mottis, Davide D'Amico, Yang Li, Gaby El Alam

Mitohormesis defines the increase in fitness mediated by adaptive responses to mild mitochondrial stress. Tetracyclines inhibit not only bacterial but also mitochondrial translation, thus imposing a low level of mitochondrial stress on eukaryotic cells. We ...

AMER SOC CLINICAL INVESTIGATION INC2022

Cyclo (His-Pro) Prevents Diet-Induced Fatty Liver Disease

Alexis Rapin, Johan Auwerx, Adrienne Joëlle Laurence Mottis, Xiaoxu Li, Alessia De Masi, Qi Wang

WILEY2022

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Mauro Delorenzi, Alexis Rapin, Dominique Velin, Esther Bovay, François Renevey

The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor Foxc ...

AMER ASSOC ADVANCEMENT SCIENCE2021

FOXC2 Controls Adult Lymphatic Endothelial Specialization, Function and Gut Lymphatic Barrier Preventing Multi-Organ Failure

Alexis Rapin

KARGER2021

Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine

Alexis Rapin, Luc Xavier Marie Lebon, Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss, Audrey Geneviève Chuat

Increasing evidence suggests that intestinal helminth infection can alter intestinal microbial communities with important impacts on the mammalian host. However, all of the studies to date utilize different techniques to study the microbiome and access dif ...

2020

Helminth-Bacterial Interactions: Cause and Consequence

Alexis Rapin, Nicola Harris

2018

Intestinal helminths modulate the gut microbiome

Alexis Rapin

Intestinal parasitic worms (commonly named intestinal helminths) affect close to one quarter of the world population and cause major losses for the livestock industry. These parasites establish chronic infections by modulation the immunity of their host. T ...

EPFL2018

Microbiota Analysis Using an Illumina MiSeq Platform to Sequence 16S rRNA Genes

Alexis Rapin, Céline Pattaroni, Nicola Harris, Benjamin John Marsland

The microbiota have been shown to play an important role in diverse biological processes including immunity, metabolism, and digestion. Assessing the exact composition of the microbiota has proven challenging due to the often unknown growth specificities o ...

2017

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Alexis Rapin, Jacques Rougemont, Laure Menin, Luc Xavier Marie Lebon, Ilaria Mosconi, Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss, Lalit Kumar Dubey, Alessandra Piersigilli, Andrew J. Macpherson

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or w ...

Elsevier2015