Publications by Kristina Schoonjans

Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

Rizlan Bernier-Latmani, Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Eduard Vico Oton, Colin Volet, Antoine Jalil

Host-microbiome communication is frequently perturbed in gut pathologies due to microbiome dysbiosis, leading to altered production of bacterial metabolites. Among these, 7 alpha-dehydroxylated bile acids are notably diminished in inflammatory bowel diseas ...

SPRINGERNATURE2025

Protecting liver health with microbial-derived succinylated bile acids

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

The gut microbiome produces a plethora of metabolites that influence host metabolism. In a recent article published in Cell, Nie and colleagues reveal that 3-succinylated cholic acid, a microbe-derived bile acid, protects against metabolic dysfunction-asso ...

OXFORD UNIV PRESS2024

A microbial-derived succinylated bile acid to safeguard liver health

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism does not involve ...

Cell Press2024

Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair

Kristina Schoonjans, Johan Auwerx

The mammalian sirtuin family (SIRT1-SIRT7) has shown diverse biological roles in the regulation and maintenance of genome stability under genotoxic stress. SIRT7, one of the least studied sirtuin, has been demonstrated to be a key factor for DNA damage res ...

2024

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Kristina Schoonjans, Johan Auwerx, Pan Xu

Aims: Sirtuin 7 (SIRT7) plays an important role in tumor development, and has been characterized as a potent regulator of cellular stress. However, the effect of SIRT7 on sorafenib acquired resistance remains unclear and a possible anti-tumor mechanism bey ...

2024

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Hadrien Charles Edouard Demagny, Xiaoxu Li, Antoine Jalil

Several laboratories, including ours, have employed the Slc25a47tm1c(EUCOMM)Hmgu mouse model to investigate the role of SLC25A47, a hepatocyte-specific mitochondrial carrier, in regulating hepatic metabolism and systemic physiology. In this study, we revea ...

2024

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Kristina Schoonjans, Petar Petrov

Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of ...

Elsevier2024

TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis

Kristina Schoonjans

Objective: Steroidogenic factor-1 (SF1) neurons of the ventromedial hypothalamus play key roles in the regulation of food intake, body weight and glucose metabolism. The bile acid receptor Takeda G protein-coupled receptor 5 (TGR5) is expressed in the hypo ...

2024

An antibiotic and a microorganism having bile acid 7α-dehydroxylation activity for treating non-infectious diseases

Kristina Schoonjans, Alessia Perino, Antoine Jalil

The present invention relates to one or more antibiotic(s) that disrupt(s) the microbial balance of the gut and a microorganism having bile acid 7α-dehydroxylation activity for use in the treatment of a non-infectious disease in a subject. ...

2024

The Bile Acid Receptor Tgr5 Regulates The Composition And Hematopoietic Support Capacity Of The Bone Marrow Microenvironment

Kristina Schoonjans, Frédérica Schyrr, Alessia Perino, Alejandro Alonso Calleja, Antoine Jalil

ELSEVIER SCIENCE INC2023

Role of TGR5 in fat-to-liver communication during NAFLD

Kristina Schoonjans, Alessia Perino

ELSEVIER2023

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Dominique Pioletti, Kristina Schoonjans, Ulrike Kettenberger, Frédérica Schyrr, Alessia Perino, Alejandro Alonso Calleja, Antoine Jalil

Smw Supporting Association2023

Asparagine protects pericentral hepatocytes during acute liver injury

Kristina Schoonjans, Alessia Perino, Ece Yildiz, Hadrien Charles Edouard Demagny, Nadia Bresciani, Yu Sun, Antoine Jalil

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

AMER SOC CLINICAL INVESTIGATION INC2023

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Alexis Rapin, Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Jean-David Horacio Morel, Xiaoxu Li

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Ece Yildiz, Giovanni Sorrentino, Gaby El Alam, Antoine Jalil

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic ...

eLIFE SCIENCES PUBL LTD2023

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Vera Monica Lemos Da Silva, Hao Li, Hadrien Charles Edouard Demagny, Nadia Bresciani, Yu Sun, Xiaoxu Li

Background & Aims: Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological r ...

ELSEVIER2022

Bile acids after bariatric surgery: a gateway to mitochondrial activation in human adipocytes

Kristina Schoonjans, Alessia Perino

SPRINGER2022

Metabolic Messengers: bile acids

Kristina Schoonjans, Alessia Perino

Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on both host and microbial metabolism. These metabolites have emerged as biologically active signalling molecules that inform organs of nutrient availability. Their action ...

2022

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Felix Naef, Kristina Schoonjans, Johan Auwerx, Hao Li, Yang Li, Wen Gao, Xiaoxu Li, Amélia Lalou, Nagammal Neelagandan, Jia Liu, Yuan Liu

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Rockefeller University Press2022

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu

Cancer progression is associated with metabolic reprogramming and causes significant intracellular stress; however, the mechanisms that link cellular stress and growth signalling are not fully understood. Here, we identified a mechanism that couples the mi ...

2022