Publications by Yu Lu | EPFL Graph Search

Soft Electrochemical Probes for Mapping the Distribution of Biomarkers and Injected Nanomaterials in Animal and Human Tissues

Hubert Girault, Horst Pick, Yu Lu, Andreas Stephan Lesch, Tzu-En Lin

Monitoring biomarkers and injected theranostic nanomaterials in tissues and organs plays a pivotal role in numerous medical applications ranging from cancer diagnostics to drug delivery. Scanning electrochemical microscopy has been demonstrated as a powerf ...

Wiley-Blackwell2017

Weiche elektrochemische Sonden zum Abbilden der Verteilung von Biomarkern und injizierten Nanomaterialien in tierischem und menschlichem Gewebe

Hubert Girault, Horst Pick, Yu Lu, Andreas Stephan Lesch, Tzu-En Lin

Die Untersuchung von Biomarkern und injizierten theranostischen Nanomaterialien in Geweben und Organen spielt eine zentrale Rolle bei zahlreichen medizinischen Verfahren von der Krebsdiagnose bis hin zur Arzneimittelverabreichung. Zu diesem Zweck kann die ...

Wiley-Blackwell2017

Electrostatic Spray Ionization Method

Romain Sartor, Yu Lu, Liang Qiao, Elena Tobolkina

In an electrostatic spray ionization method for spraying a liquid layer from an insulating plate 2, the plate is arranged between two electrodes 1, 4. A constant high voltage power supply 3 is provided and an electric circuit is used to charge and discharg ...

2015

Dual-Channel Electrospray Microchip

Hubert Girault, Niels Erik Lion, Yu Lu, Fang Liu

A dual-channel electrospray microchip has been developed for electrospray ionization mass spectrometry (ESI-MS) where aqueous samples are mixed at the Taylor cone with an organic buffer. Due to the fast and effective mixing in the Taylor cone, the aqueous ...

2013

Electrostatic-Spray Ionization Mass Spectrometry

Hubert Girault, Romain Sartor, Yu Lu, Liang Qiao, Elena Tobolkina, Natalia Gasilova

An electrostatic-spray ionization (ESTASI) method has been used for mass spectrometry (MS) analysis of samples deposited in or on an insulating substrate. The ionization is induced by a capacitive coupling between an electrode and the sample. In practice, ...

Amer Chemical Soc2012

Microchip Based Electrospray Mass Spectrometry for Investigation of Neurodegenerative Peptides

Yu Lu

Electrospray ionization mass spectrometry (ESI-MS) is a powerful tool to investigate large molecules. Miniaturized microchips, as a goal of ‘Lab-on-chip’, allow various integrated analysis quickly. The coupling of functional microchips and ESI-MS is capabl ...

EPFL2012

In-Spray Supercharging of Peptides and Proteins in Electrospray Ionization Mass Spectrometry

Hubert Girault, Yury Tsybin, Yu Lu, Luca Fornelli, Sasa Miladinovic, Krzysztof Marek Piech

Enhanced charging, or supercharging, of analytes in electrospray ionization mass spectrometry (ESI MS) facilitates high resolution MS by reducing an ion mass-to-charge (m/z) ratio, increasing tandem mass spectrometry (MS/MS) efficiency. ESI MS superchargin ...

2012

Melittin Adsorption and Lipid Monolayer Disruption at Liquid-Liquid Interfaces

Hubert Girault, Manuel Alejandro Méndez Agudelo, Yu Lu, Zahra Nazemi

Melittin, a membrane-active peptide with antimicrobial activity, was investigated at the interface formed between two immiscible electrolyte solutions (ITIES) supported on a metallic electrode. Ion-transfer voltammetry showed well-defined semi-reversible t ...

American Chemical Society2011

Phosphorylation of alpha-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of alpha-Synuclein in the Pathogenesis of Parkinson's Disease and Related Disorders

Hubert Girault, Michel Prudent, Bruno Claude Daniel Fauvet, Hilal Lashuel, Yu Lu

alpha-Synuclein (alpha-syn) is a 140-amino acid protein that plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. However, the molecular determinants that are responsible for triggering and/or propagating alpha- ...

American Chemical Society2011

Interfacial Complexation Reactions of Sr2+ with Octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine Oxide for Understanding Its Extraction in Reprocessing Spent Nuclear Fuels

Hubert Girault, Zhifeng Ding, Yu Lu, Thomas James Stockmann

The complexation reactions between strontium (Sr2+) and octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide (CMPO) were studied at the aqueous vertical bar 1,2-dichloroethane (w vertical bar DCE) and aqueous vertical bar room-temperature ionic liqui ...

2011

Copper-Catalyzed Tyrosine Nitration

Hubert Girault, Yu Lu, Liang Qiao

Tyrosine nitration, often observed during neurodegenerative disorders under nitrative stress, is usually considered to be induced chemically either by nitric oxide and oxygen forming nitrogen dioxide or by the decomposition of peroxynitrite. It can also be ...

2011

Copper(I) and copper(II) binding to β-amyloid 16 (Aβ16) studied by electrospray ionization mass spectrometry

Hubert Girault, Michel Prudent, Yu Lu, Liang Qiao

Copper-b-amyloid 16 (Aβ16) complexes were investigated by electrospray ionization mass spectrometry (ESI-MS). Copper(I) and (II) complexes were formed on-line in a microchip electrospray emitter by using a sacrificial copper electrode as the anode in posit ...

Royal Society of Chemistry2010