Publications by Débora Bonvin

Local Temperature Increments and Induced Cell Death in Intracellular Magnetic Hyperthermia

The generation of temperature gradients on nanoparticles heated externally by a magnetic field is crucially important in magnetic hyperthermia therapy. But the intrinsic low heat i n g power of magnetic nanoparticles, at the conditions allowed for human us ...

AMER CHEMICAL SOC2023

Magnetic hyperthermia with epsilon-Fe(2)O(3)nanoparticles

Débora Bonvin

Biocompatibility restrictions have limited the use of magnetic nanoparticles for magnetic hyperthermia therapy to iron oxides, namely magnetite (Fe3O4) and maghemite (gamma-Fe2O3). However, there is yet another magnetic iron oxide phase that has not been c ...

2020

Versatility of Pyridoxal Phosphate as a Coating of Iron Oxide Nanoparticles

Heinrich Hofmann, Ulrich Aschauer, Marijana Mionic Ebersold, Débora Bonvin, Josefina Adriana Maria Bastiaansen

Pyridoxal 5'-phosphate (PLP) is the most important cofactor of vitamin B-6-dependent enzymes, which catalyses a wide range of essential body functions (e.g., metabolism) that could be exploited to specifically target highly metabolic cells, such as tumour ...

Mdpi Ag2017

Controlling structural and magnetic properties of IONPs by aqueous synthesis for improved hyperthermia

Heinrich Hofmann, Alla Arakcheeva, Marijana Mionic Ebersold, Débora Bonvin

Iron oxide nanoparticles (IONPs) were synthesized by a novel aqueous synthesis route which combines co-precipitation (CP) and hydrothermal (HT) treatment, termed CP + HT, and compared with IONPs obtained by the standard CP method. Properties of both types ...

2017

Folic acid on iron oxide nanoparticles: platform with high potential for simultaneous targeting, MRI detection and hyperthermia treatment of lymph node metastases of prostate cancer

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin, Josefina Adriana Maria Bastiaansen

The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, ver ...

Royal Society of Chemistry2017

Assessment of nanoparticles’ safety: corrected absorbance-based toxicity test

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin

We developed a method to correct absorbance-based toxicity tests to remove the influence of the deposited dose of nano-particles. As a model of absorbance-based toxicity tests, we chose the frequently used MTS test. The corrected cell viabilities obtained ...

Royal Soc Chemistry2017

Chelating agents as coating molecules for iron oxide nanoparticles

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin, Josefina Adriana Maria Bastiaansen

Due to their high chemical affinity towards metal ions, chelating agents (CAs) have been used for decades for water purification, but also for protection against metal intoxication and in nanomedicine as linking molecules at the surface of nanoparticles. H ...

RSC Publishing2017

Methods of protein corona isolation for magnetic nanoparticles

Heinrich Hofmann, Marc Moniatte, Diego Chiappe, Marijana Mionic Ebersold, Débora Bonvin

Nanoparticles (NPs) in contact with a biological environment get covered by proteins and some are loosely bound and some are tightly bound. The latter form a hard protein corona (HPC) which is known to determine their biological behavior. Therefore, in ord ...

Royal Soc Chemistry2017

Iron oxide nanoparticles for diagnosis and therapy of lymph node metastases

Débora Bonvin

This thesis presents the synthesis, coating and characterization of iron oxide nanoparticles (IONPs) with properties especially designed for the ultimate simultaneous MRI detection and hyperthermia treatment of lymph node metastases, a combination called t ...

EPFL2017

Protein Corona: Impact of Lymph Versus Blood in a Complex In Vitro Environment

Heinrich Hofmann, Ulrich Aschauer, Marc Moniatte, Diego Chiappe, Marijana Mionic Ebersold, Duncan Thomas Lindsay Alexander, Débora Bonvin

In biological environments, the surface of nanoparticles (NPs) are modified by protein corona (PC) that determines their biological behavior. Unfortunately, in vitro tests still give different PC than in vivo tests causing in vitro-in vivo discrepancy; hen ...

Wiley-Blackwell2017

Optimisation of aqueous synthesis of iron oxide nanoparticles for biomedical applications

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin

Iron oxide nanoparticles (IONPs) were prepared via aqueous synthesis which combines alkaline co-precipitation (CP) of ferric and ferrous precursors with mild hydrothermal (HT) treatment without cupping agents (CA). In this novel synthesis route, CP + HT, w ...

Springer Verlag2016

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin, Edoardo Scherrer

Tumor vasculature is known to be poorly organized leading to increased leakage of molecules to the extravascular space. This process can potentially increase interstitial fluid pressure impairing intra-tumoral blood flow and oxygen supply, and can affect d ...

Nature Publishing Group2015

Sequential combination of axitinib with photodynamic therapy synergistically delays tumor growth in a preclinical model of human ovarian carcinoma

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Débora Bonvin

Springer2014

Combination of low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy in human carcinoma models: lack of vascular normalization

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin

Springer2014

Low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy for cancer: lack of vascular normalization

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin

Photodynamic therapy (PDT) is an effective clinical treatment for a number of different cancers. PDT can induce hypoxia and inflammation, pro-angiogenic side effects, which may counteract its angio-occlusive mechanism. The combination of PDT with anti-angi ...

2014