Publications by Frédéric Pierre Gérald Michoud

Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants

Bernard Schneider, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Ivan Furfaro, Valentina Marie Paggi

Hyperexcitability of peripheral sensory neurons plays a critical role in the development and maintenance of chronic pain. Pharmacological analgesics used in clinics reduce neuronal activity. They often come with non‐negligible side effects. Optogenetic app ...

Wiley2025

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Léonie Asboth, Jérôme Gandar, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Noaf Salah Ali Alwahab, Ivan Furfaro, Ileana Ozana Jelescu, Andreas Rowald, Claudia Kathe, Valentina Marie Paggi, Jimmy James Ravier, Kyungjin Kim, Thomas Haynes Hutson

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Katia Galan, Ivan Furfaro, Outman Akouissi

Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation(1,2), but whether nociceptors also interact with the immune system remains poorly understo ...

NATURE RESEARCH2020

Soft multimodal neural interfaces for unravelling sensory neurological circuits

Frédéric Pierre Gérald Michoud

Diseases or injuries affecting the nervous system can dramatically disrupt the quality of life. Despite extensive efforts towards treating dysfunctional nervous systems, the pharmacological and electrical approaches generally involved lack the temporal and ...

EPFL2019

Optical cuff for optogenetic control of the peripheral nervous system

Léonie Asboth, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Loïc Sottas, Grégoire Courtine

Objective. Nerves in the peripheral nervous system (PNS) contain axons with specific motor, somatosensory and autonomic functions. Optogenetics offers an efficient approach to selectively activate axons within the nerve. However, the heterogeneous nature o ...

2018

A Wireless System with Stimulation and Recording Capabilities for Interfacing Peripheral Nerves in Rodents

Qiuting Huang, Amélie Anne Guex, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Noé Brun

Considerable progress has been made in the last decade in implantable bioelectronic neurosystems. Yet most neural implants are used in acute and tethered experimental conditions. Here, we present a preliminary prototype of a multichannel system for simulta ...

2016

Correlation between muscular and nerve signals responsible for hand grasping in non-human primates

Frédéric Pierre Gérald Michoud

Neuroprosthetic devices that interface with the nervous system to restore functional motor activity offer a viable alternative to nerve regeneration, especially in proximal nerve injuries like brachial plexus injuries where muscle atrophy may set in before ...

IEEE2014