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Larissa Grolimund

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Related publications (3)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

Joachim Lingner, Jérôme Crittin, Larissa Grolimund, Verena Pfeiffer

Telomere maintenance by the conventional DNA replication machinery and telomerase is assisted by specialized DNA helicases, nucleases and telomere binding proteins. Here, we identify the THO components at telomeres and define critical roles of this complex ...

Nature Publishing Group2013

A quantitative telomeric chromatin isolation protocol identifies different telomeric states

Joachim Lingner, Marc Moniatte, Diego Chiappe, Larissa Grolimund, Florence Armand, Romain Hamelin, Eric Aeby

Telomere composition changes during tumourigenesis, aging and in telomere syndromes in a poorly defined manner. Here we develop a quantitative telomeric chromatin isolation protocol (QTIP) for human cells, in which chromatin is cross-linked, immunopurified ...

Nature Publishing Group2013

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

Larissa Grolimund

Telomeres protect linear ends of eukaryotic chromosomes by preventing chromosomal end-to-end fusions and telomere attrition. They consist of repetitive DNA sequences, telomeric repeat containing RNAs (TERRAs) and proteins. Telomeres play a crucial role in ...

EPFL2013