Publications by Giuseppe Schiavone

Protocol for fabricating a reusable plate-well insert with a 3D-printed mounter and hydrogel scaffolds for 3D cell culture and functional assays

We present a protocol for the fabrication of reusable inserts for standard 24-well plates, comprising a 3D-printed mounter and a hydrogel scaffold for 3D cell culture studies. We cover the design and production of the mounter, hydrogel scaffold synthesis, ...

2025

A low-profile electromechanical packaging system for soft-to-flexible bioelectronic interfaces

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Florent-Valéry Coen, Alix Esther Anne Trouillet

Interfacing the human body with the next generation of electronics requires technological advancement in designing and producing bioelectronic circuits. These circuits must integrate electrical functionality while simultaneously addressing limitations in m ...

2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Tomislav Milekovic, Léonie Asboth, Camille Georgette Marie Le Goff-Mignardot, Giuseppe Schiavone, Elvira Pirondini, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean François Pierre Laurens, Jean-Baptiste Mignardot, Flavio Raschella, Robin Jonathan Demesmaeker, Simon Borgognon, Jocelyne Bloch, Shiqi Sun, Sergio Daniel Hernandez, Jordan Squair, Nicolò Macellari, Jimmy James Ravier, Carmina Andrea Galvez Solano, Grégory Didier Dumont

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Tomislav Milekovic, Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Katia Galan, Jocelyne Bloch, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

Chronic recording of cortical activit y underlying vocalization in awake minipigs

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022

A modular strategy for next-generation upper-limb sensory-motor neuroprostheses

Solaiman Shokur, Giuseppe Schiavone, Silvestro Micera

Neuroprosthetics is a discipline that aims at restoring lost functions to people affected by a variety of neurological disorders or neuro-traumatic lesions. It combines the expertise of computer science and electrical, mechanical, and micro/nanotechnology ...

ELSEVIER2021

MRI-Compatible and Conformal Electrocorticography Grids for Translational Research

Giuseppe Schiavone, Ludovic Serex, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Fabien Bertrand Paul Wagner

Intraoperative electrocorticography (ECoG) captures neural information from the surface of the cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter-sized elec ...

2021

Extended Barrier Lifetime of Partially Cracked Organic/Inorganic Multilayers for Compliant Implantable Electronics

Yves Leterrier, Giuseppe Schiavone, Stéphanie Lacour, Kyungjin Kim, Kangling Wu

Flexible and soft bioelectronics display conflicting demands on miniaturization, compliance, and reliability. Here, the authors investigate the design and performance of thin encapsulation multilayers against hermeticity and mechanical integrity. Partially ...

WILEY-V C H VERLAG GMBH2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Jérôme Gandar, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Salif Axel Komi, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Eduardo Martin Moraud, Marco Capogrosso, Mark Andrew Anderson, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Ileana Ozana Jelescu, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Laura Ann McCracken, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Jimmy James Ravier

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Microscale Liquid Metal Conductors for Stretchable and Transparent Electronics

Giuseppe Schiavone, Laurent Mirko Dejace, Stéphanie Lacour, Ivan Furfaro, Haotian Chen

Integrated wearable electronics capable of transducing and transmitting biophysical information on complex and dynamic systems are attracting high interest across the consumer electronics, clinical, and research domains. Gallium and gallium-based liquid me ...

Wiley2021

Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Nathan Antoine Greiner, Simon Borgognon, Nicholas David James, Henri Charles Alexandre Lorach

Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting t ...

Nature Research2021

Dimensional scaling of thin-film stimulation electrode systems in translational research

Giuseppe Schiavone, Nicolas Vachicouras, Stéphanie Lacour

Objective. Electrical stimulation of biological tissue is an established technique in research and clinical practice that uses implanted electrodes to deliver electrical pulses for a variety of therapies. Significant research currently explores new electro ...

2021

Hybrid soft-rigid electrical interconnection system

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour

It is disclosed an electrical interconnection system comprising: i) an interconnection board comprising an intrinsically non elastic substrate, said substrate having a first face and an opposed second face, and at least one conductive track on and/or withi ...

2021

Soft, Implantable Bioelectronic Interfaces for Translational Research

Sébastien Jiguet, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Evgenia Vladimirova Roussinova, Ivan Furfaro, Andreas Rowald, Beatrice Barra, Simon Borgognon, Jocelyne Bloch, Xiaoyang Kang, Ismael Seanez Gonzalez

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour

Conformable bioelectronic systems are promising tools that may aid the understanding of diseases, alleviate pathological symptoms such as chronic pain, heart arrhythmia, and dysfunctions, and assist in reversing conditions such as deafness, blindness, and ...

Wiley2020

Guidelines to Study and Develop Soft Electrode Systems for Neural Stimulation

Jérôme Gandar, Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Xiaoyang Kang

2020

Structured nanoscale metallic glass fibres with extreme aspect ratios

Giuseppe Schiavone, Güven Kurtuldu, Inès Richard, Stéphanie Lacour, Grégoire Courtine, Dang Tùng Nguyen, Fabien Sorin, Wei Yan, Yunpeng Qu, Vasiliki Tileli, Nicholas David James, Jordan Squair, Reinis Ignatans

Micro- and nanoscale metallic glasses offer exciting opportunities for both fundamental research and applications in healthcare, micro-engineering, optics and electronics. The scientific and technological challenges associated with the fabrication and util ...

Nature Publishing Group2020

Stretchable cuff device

Giuseppe Schiavone, Ludovic Serex, Nicolas Vachicouras, Florian Dylan Fallegger, Valentina Marie Paggi

The invention features a cuff device comprising a support having a first end, a second end and an elongated body in between; connection means for electrical, magnetic and/or fluidic magnetic connection with external devices; at least one of i) an electrode ...

2020

Automatic clustering of spinal reflexes evoked by epidural electrical stimulation of the cervical spinal cord in non-human primates

Giuseppe Schiavone, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Sara Conti, Beatrice Barra, Katie Zhi Zhuang, Jocelyne Bloch

Epidural electrical stimulation of the spinal cord elicits motor responses by recruiting large sensory afferents in the posterior roots. Divergence of excitatory inputs provided by these fibers generates a variety of shapes, latencies and amplitudes in the ...

2019

Conformable bioelectronic interfaces: Mapping the road ahead

Giuseppe Schiavone, Stéphanie Lacour

2019