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Michael Reimann

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Related publications (29)

Morphological Diversity Strongly Constrains Synaptic Connectivity and Plasticity

Henry Markram, Srikanth Ramaswamy, Eilif Benjamin Muller, Michael Reimann, Anna-Lena Horlemann

Synaptic connectivity between neurons is naturally constrained by the anatomical overlap of neuronal arbors, the space on the axon available for synapses, and by physiological mechanisms that form synapses at a subset of potential synapse locations. What i ...

Oxford University Press (OUP)2017

Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function

Kathryn Hess Bellwald, Henry Markram, Rodrigo de Campos Perin, Michael Reimann, Giuseppe Chindemi, Ran Levi, Max Christian Nolte, Pawel Tadeusz Dlotko, Katharine Felicity Turner, Martina Scolamiero

The lack of a formal link between neural network structure and its emergent function has hampered our understanding of how the brain processes information. We have now come closer to describing such a link by taking the direction of synaptic transmission i ...

Frontiers Media Sa2017

Rich cell-type-specific network topology in neocortical microcircuitry

Henry Markram, Srikanth Ramaswamy, Eilif Benjamin Muller, Idan Segev, Michael Reimann, Eyal Gal, Michael London

Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a similar to 0.3-mm(3) volum ...

Nature Publishing Group2017

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Selim Arsever, Henry Markram, Raphael Dumusc, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Sean Lewis Hill, Juan Bautista Hernando Vieites, Eilif Benjamin Muller, Daniel Keller, Idan Segev, Michael Reimann, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, Stefan Eilemann, Guy Antoine Atenekeng Kahou, Jeffrey Christopher Muller, Lida Kanari, Stefano Zaninetta, Giuseppe Chindemi, Jafet Villafranca Diaz, Yury Brukau, Michael Emiel Gevaert, Stanislaw Ryszard Adaszewski, Nicolas Antille

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

2015

Reconstruction and Simulation of Neocortical Microcircuitry

Nenad Buncic, Jean-Vincent Le Bé, Selim Arsever, Henry Markram, Gilad Silberberg, Sébastien Lasserre, Vincent Delattre, Raphael Dumusc, Rodrigo de Campos Perin, Imad Riachi, Thomas Berger, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Michael Lee Hines, Sean Lewis Hill, Juan Bautista Hernando Vieites, Georges Khazen, Shruti Muralidhar, Anastasia Ailamaki, Eilif Benjamin Muller, Farhan Tauheed, Jean Pierre Ghobril, Julie Meystre, Daniel Keller, Idan Segev, Michael Reimann, Thomas Heinis, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, , , , , , , , , , , , , , , , , , , , , , , , , , , ,

An algorithm to predict the connectome of neural microcircuits

Henry Markram, James Gonzalo King, Srikanth Ramaswamy, Eilif Benjamin Muller, Michael Reimann

Experimentally mapping synaptic connections, in terms of the numbers and locations of their synapses and estimating connection probabilities, is still not a tractable task, even for small volumes of tissue. In fact, the six layers of the neocortex contain ...

Frontiers Research Foundation2015

Structural to functional synaptic conversion

Henry Markram, Felix Schürmann, James Gonzalo King, Sean Lewis Hill, Eilif Benjamin Muller, Michael Reimann

Computer-implemented methods, software, and systems for determining functional synapses from given structural touches between cells in a neuronal circuit are described. One computer-implemented method for determining functional synapses from predetermined ...

Technology Transfer Office EPFL2015

The In-Silico Neocortical Microcircuit : From Structure to Dynamics

Michael Reimann

The neocortex is one of the most important brain regions, occupying more than 80% of the brain volume in mammals and contributing massively to its capability of perceiving and interpreting then environment. While it has been extensively studied, it is stil ...

EPFL2014

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Henry Markram, Rodrigo de Campos Perin, Sean Lewis Hill, Michael Reimann

Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but ne ...

Elsevier2013

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Frontiers Research Foundation

Keerthan Muthurasa

Stefan Eilemann

Guy Antoine Atenekeng Kahou

Jeffrey Christopher Muller

Carlos Aguado Sanchez

Jafet Villafranca Diaz

Aleksandr Ovcharenko

Juan Luis Riquelme Roman

Benjamin Roy Morrice

James Alexander Dynes

Michael Emiel Gevaert

Juan Pablo Palacios

Pramod Shivaji Kumbhar

Ricardo Manuel Salgueiro Domingues Da Silva

Max Christian Nolte

Zoltan Kisvarday

Nicolas Antille

Lidia Alonso-Nanclares

Taylor Howard Newton

Alberto Munoz Cespedes

Anirudh Gupta

Michael John Kenyon

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015