Publications by Tanguy Jean Daniel Saget

Enantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system

Tanguy Jean Daniel Saget, Nicolai Cramer, Pavel Alexandrovich Donets, Julia Pedroni

Taddol-based phosphoramidite ligands enable enantioselective palladium(0)-catalyzed C-H arylation of cyclopropanes. The cyclized products are obtained in high yields and enantioselectivities. The reported method provides efficient access to a broad range o ...

Royal Soc Chemistry2015

Access to beta-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp(3))-H Alkylation

Tanguy Jean Daniel Saget, Nicolai Cramer, Michele Boghi, Julia Pedroni

beta-Lactams are very important structural motifs because of their broad biological activities as well as their propensity to engage in ring-opening reactions. Transitionmetal- catalyzed C-H functionalizations have emerged as strategy enabling yet uncommon ...

Wiley-Blackwell2014

Enantioselective palladium(0)-catalyzed C-H arylation strategy for chiral heterocycles

Tanguy Jean Daniel Saget, Nicolai Cramer

Transition-metal-catalyzed C-H functionalizations have emerged as complementary and powerful tools to access molecular complexity from widely available starting materials. Herein, we present a strategy for asymmetric intramolecular Pd(0)-catalyzed C-H func ...

De Gruyter2014

Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylation

Tanguy Jean Daniel Saget, Nicolai Cramer

The synthesis of cyclopropyl spiroindolines is described using an intramolecular palladium(0)-catalyzed C-H functionalization of a methine C(sp(3))-H bond. This transformation can be coupled with intermolecular Suzuki couplings or direct arylations of hete ...

Amer Chemical Soc2013

Enantioselective C-H Arylation Strategy for Functionalized Dibenzazepinones with Quaternary Stereocenters

Tanguy Jean Daniel Saget, Nicolai Cramer

Wiley-VCH Verlag GmbH2013

Heteroatom Nucleophile Induced C-C Fragmentations to Access Functionalized Allenes

Tanguy Jean Daniel Saget, Nicolai Cramer

The rich structural and reactivity profile of allenes render them versatile synthetic intermediates. However, application of allenes in organic chemistry is often attenuated by inconvenient methods of preparation. Herein we present an operationally simple ...

2012

Chiral Monodentate Trialkylphosphines Based on the Phospholane Architecture

Tanguy Jean Daniel Saget, Nicolai Cramer, Pavel Alexandrovich Donets

The development of efficient chiral monodentate phosphine ligands lags behind that of the bidentate congeners. This holds especially true for highly electron rich chiral phosphine analogues able to replace the ubiquitous tricyclohexylphosphine and tri-tert ...

Amer Chemical Soc2012

Chiral Monodentate Phosphines and Bulky Carboxylic Acids: Cooperative Effects in Palladium-Catalyzed Enantioselective C(sp3)-H Functionalization

Tanguy Jean Daniel Saget, Nicolai Cramer, Sébastien José Lemouzy

Wiley-VCH Verlag GmbH2012

Palladium(0)-Catalyzed Enantioselective C-H Arylation of Cyclopropanes: Efficient Access to Functionalized Tetrahydroquinolines

Tanguy Jean Daniel Saget, Nicolai Cramer

Wiley-VCH Verlag GmbH2012

Formal Homo-Nazarov and Other Cyclization Reactions of Activated Cyclopropanes

Jérôme Waser, Filippo De Simone, Tanguy Jean Daniel Saget, Fides Benfatti

The Nazarov cyclization of divinyl ketones gives access to cyclopentenones. Replacing one of the vinyl groups by a cyclopropane leads to a formal homo-Nazarov process for the synthesis of cyclohexenones. In contrast to the Nazarov reaction, the cyclization ...

2011

Convenient Preparation of Tri-tert-butylphosphonium Tetrafluoroborate

Tanguy Jean Daniel Saget, Nicolai Cramer

The versatile tri-tert-butylphosphonium tetrafluoroborate ligand is prepared in a convenient, simple, and high-yielding procedure without the isolation of sensitive intermediates. ...

2011