Alexandra Iouranova

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Related publications (5)

KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Jonas Caspar De Tribolet-Hardy, Alexandra Iouranova, Michaël Imbeault, Alexandre Coudray, Tamara Rossy, Alexandre Louis André Persat, Delphine Yvette L Grun

Background Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the contribution of this system to g ...

2022

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos

Alexandra Iouranova

Transposable elements (TEs), also called jumping genes, are genetic elements capable of changing their position within the genome of their host. They make up large fractions of genomes, including 45% of human DNA content, according to current estimates. S ...

EPFL2021

KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Julien Duc, Alexandra Iouranova, Michaël Imbeault, Alexandre Coudray

MARY ANN LIEBERT, INC2018

Molecular Criteria for Defining the Naive Human Pluripotent State

Didier Trono, Julien Léonard Duc, Marc Samuel Friedli, Alexandra Iouranova, Michaël Imbeault, Evaristo Jose Planet Letschert, Julien Paul André Pontis, Haoyi Wang

Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency. Here we propose a set of molecular criteria for evaluating the naive ...

Cell Press2016

IROme, a New High-Throughput Molecular Tool for the Diagnosis of Inherited Retinal Dystrophies

Tatiana Favez, Alexandra Iouranova, Pascal Escher

The molecular diagnosis of retinal dystrophies is difficult because of the very important number of genes implicated and is rarely helped by genotype-phenotype correlations. This prompted us to develop IROme, a custom designed in solution-based targeted ex ...

Hindawi Publishing Corporation2013

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