Hirohito Haruki

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Related publications (5)

Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid

Rudolf Hovius, Kai Johnsson, Miriam Grønlund Pedersen, Hirohito Haruki

Tryptophan metabolites in the kynurenine pathway are up-regulated by pro-inflammatory cytokines or glucocorticoids, and are linked to anti-inflammatory and immunosuppressive activities. In addition, they are up-regulated in pathologies such as cancer, auto ...

Amer Soc Biochemistry Molecular Biology Inc2015

Tetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa Drugs

Kai Johnsson, Florence Pojer, Miriam Grønlund Pedersen, Hirohito Haruki, Katarzyna Irena Gorska

The introduction of sulfa drugs for the chemotherapy of bacterial infections in 1935 revolutionized medicine. Although their mechanism of action is understood, the molecular bases for most of their side effects remain obscure. Here, we report that sulfamet ...

American Association for the Advancement of Science2013

Exploiting Ligand-Protein Conjugates to Monitor Ligand-Receptor Interactions

Kai Johnsson, Monica Rengifo Gonzalez, Hirohito Haruki

We introduce three assays for analyzing ligand-receptor interactions based on the specific conjugation of ligands to SNAP-tag fusion proteins. Conjugation of ligands to different SNAP-tag fusions permits the validation of suspected interactions in cell ext ...

Public Library of Science2012

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis

Kai Johnsson, Christopher Chidley, Evelyne Muller, Miriam Grønlund Pedersen, Hirohito Haruki

2011

Searching for the Protein Targets of Bioactive Molecules

Kai Johnsson, Christopher Chidley, Cindy Fellay, Miriam Grønlund Pedersen, Simone Moser, Hirohito Haruki

The identification of all protein targets of a given drug or bioactive molecule within the human body is a prerequisite for an understanding of its beneficial and deleterious activities. Current approaches to reveal protein targets often fail to reveal phy ...

Schweizerische Chemische Gesellschaft2011

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