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Tom Hilbert

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Related publications (68)

Brain morphometry in older adults with and without dementia using extremely rapid structural scans

T1-weighted structural MRI is widely used to measure brain morphometry (e.g., cortical thickness and subcortical volumes). Accelerated scans as fast as one minute or less are now available but it is unclear if they are adequate for quantitative morphometry ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

SPARCQ: A new approach for fat fraction mapping using asymmetries in the phase-cycled balanced SSFP signal profile

Katarzyna Pierzchala, Tobias Kober, Tom Hilbert

Purpose: To develop SPARCQ (Signal Profile Asymmetries for Rapid Compartment Quantification), a novel approach to quantify fat fraction (FF) using asymmetries in the phase-cycled balanced SSFP (bSSFP) profile. ...

WILEY2023

Q-Dixon and GRAPPATINI T2 Mapping Parameters: A Whole Spinal Assessment of the Relationship Between Osteoporosis and Intervertebral Disc Degeneration

Tobias Kober, Tom Hilbert

Background The relationship between osteoporosis and intervertebral disc (IVD) degeneration remains controversial. Novel quantitative Dixon (Q-Dixon) and GRAPPATINI T2 mapping techniques have shown potential for evaluating the biochemical components of the ...

WILEY2022

Value of T-2 Mapping MRI for Prostate Cancer Detection and Classification

Tom Hilbert

Background Currently, multi-parametric prostate MRI (mpMRI) consists of a qualitative T-2, diffusion weighted, and dynamic contrast enhanced imaging. Quantification of T-2 imaging might further standardize PCa detection and support artificial intelligence ...

WILEY2022

First evidence on the utility of T-1 mapping of the optic nerve to investigate differences between MS and NMOSD

Jean-Philippe Thiran, Bénédicte Marie Maréchal, Tobias Kober, Tom Hilbert, Veronica Lily Ravano, Gian Franco Piredda

SAGE PUBLICATIONS LTD2022

T2 mapping for the characterization of prostate lesions

Tom Hilbert

Purpose Purpose of this study is to evaluate the diagnostic accuracy of quantitative T2/ADC values in differentiating between PCa and lesions showing non-specific inflammatory infiltrates and atrophy, features of chronic prostatitis, as the most common his ...

SPRINGER2022

Evaluating reproducibility and subject-specificity of microstructure-informed connectivity

Jean-Philippe Thiran, Tobias Kober, Elda Fischi Gomez, Tom Hilbert, Elena Beanato, Gabriel Girard, Julia Brügger, Gian Franco Piredda, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Erick Jorge Canales Rodriguez, Marco Pizzolato, Andéol Geoffroy Cadic-Melchior, Chang-Hyun Park

Tractography enables identifying and evaluating the healthy and diseased brain's white matter pathways from diffusion-weighted magnetic resonance imaging data. As previous evaluation studies have reported significant false-positive estimation biases, recen ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Towards better characterization of spinal cord pathology in early stages of multiple sclerosis using T1 mapping

Bénédicte Marie Maréchal, Tobias Kober, Tom Hilbert, Veronica Lily Ravano, Gian Franco Piredda

SAGE PUBLICATIONS LTD2022

Comparison of T2 Quantification Strategies in the Abdominal-Pelvic Region for Clinical Use

Tom Hilbert

Objectives The aim of the study was to compare different magnetic resonance imaging (MRI) acquisition strategies appropriate for T2 quantification in the abdominal-pelvic area. The different techniques targeted in the study were chosen according to 2 main ...

LIPPINCOTT WILLIAMS & WILKINS2022

Assessment of idiopathic inflammatory myopathy using a deep learning method for muscle T2 mapping segmentation

Tobias Kober, Tom Hilbert, Qian Wang, Yubo Zhao, Yao Zhang

Objective To investigate the utility of an automatic deep learning (DL) method for segmentation of T2 maps in patients with idiopathic inflammatory myopathy (IIM) against healthy controls, and also the association of quantitative T2 values in patients with ...

SPRINGER2022

Periventricular gradient of T1 tissue alterations in multiple sclerosis

Bénédicte Marie Maréchal, Tobias Kober, Tom Hilbert, Veronica Lily Ravano, Gian Franco Piredda

Objective: Pathology in multiple sclerosis is not homogenously distributed. Recently, it has been shown that structures adjacent to CSF are more severely affected. A gradient of brain tissue involvement was shown with more severe pathology in periventricul ...

ELSEVIER SCI LTD2022

A Fetal Brain magnetic resonance Acquisition Numerical phantom (FaBiAN)

Tobias Kober, Tom Hilbert, Thomas Yu

Accurate characterization of in utero human brain maturation is critical as it involves complex and interconnected structural and functional processes that may influence health later in life. Magnetic resonance imaging is a powerful tool to investigate equ ...

Nature Portfolio2022

Simultaneous 3D acquisition of H-1 MRF and Na-23 MRI

Tom Hilbert

Purpose To develop a 3D MR technique to simultaneously acquire proton multiparametric maps (T-1, T-2, and proton density) and sodium density weighted images over the whole brain. Methods We implemented a 3D stack-of-stars MR pulse sequence which consists o ...

WILEY2022

Variability and reproducibility of multi-echo T2 relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions

Jean-Philippe Thiran, Tobias Kober, Elda Fischi Gomez, Alessandro Daducci, Tom Hilbert, Elena Beanato, Gabriel Girard, Julia Brügger, Gian Franco Piredda, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Erick Jorge Canales Rodriguez, Marco Pizzolato, Andéol Geoffroy Cadic-Melchior, Thomas Yu, Chang-Hyun Park

Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values acqu ...

2022

Submillimeter T-1 atlas for subject-specific abnormality detection at 7T

Jean-Philippe Thiran, Bénédicte Marie Maréchal, Tobias Kober, Tom Hilbert, Ricardo Alberto Corredor Jerez, Gian Franco Piredda

Purpose: Studies at 3T have shown that T-1 relaxometry enables characterization of brain tissues at the single-subject level by comparing individual physical properties to a normative atlas. In this work, an atlas of normative T-1 values at 7T is introduce ...

WILEY2022

Compressed sensing (CS) MP2RAGE versus standard MPRAGE: A of derived brain volume measurements

Tobias Kober, Tom Hilbert, Gian Franco Piredda

Purpose: T1 Magnetization Prepared Two Rapid Acquisition Gradient Echo (MP2RAGE) with compress sensing (CS) has been proposed as an improvement of the standard MPRAGE sequence with multiple advantages including reduced acquisition time needed to provide a ...

ELSEVIER SCI LTD2022

Comparison of non-parametric T2 relaxometry methods for myelin water quantification

Jean-Philippe Thiran, Nicolas Kunz, Tobias Kober, Alessandro Daducci, Tom Hilbert, Gian Franco Piredda, Erick Jorge Canales Rodriguez, Marco Pizzolato, Thomas Yu

Multi-component T2 relaxometry allows probing tissue microstructure by assessing compartment-specific T2 relaxation times and water fractions, including the myelin water fraction. Non-negative least squares (NNLS) with zero-order Tikhonov regularization is ...

2021

Differentiation between benign and malignant vertebral compression fractures using qualitative and quantitative analysis of a single fast spin echo T2-weighted Dixon sequence

Sébastien Bacher, Tom Hilbert

Objectives To determine and compare the qualitative and quantitative diagnostic performance of a single sagittal fast spin echo (FSE) T2-weighted Dixon sequence in differentiating benign and malignant vertebral compression fractures (VCF), using multiple r ...

SPRINGER2021

Revisiting the T-2 spectrum imaging inverse problem: Bayesian regularized non-negative least squares

Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Marco Pizzolato, Thomas Yu

Multi-echo T-2 magnetic resonance images contain information about the distribution of T-2 relaxation times of compartmentalized water, from which we can estimate relevant brain tissue properties such as the myelin water fraction (MWF). Regularized non-neg ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2021

Data-driven myelin water imaging based on T-1 and T-2 relaxometry

Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Marco Pizzolato

Long acquisition times preclude the application of multiecho spin echo (MESE) sequences for myelin water fraction (MWF) mapping in daily clinical practice. In search of alternative methods, previous studies of interest explored the biophysical modeling of ...

WILEY2021

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