Publications by Juan Camilo Paredes Escobar

Blind killing of both male and female Drosophila embryos by a natural variant of the endosymbiotic bacterium Spiroplasma poulsonii

Bruno Lemaitre, Juan Camilo Paredes Escobar, Mario Gonzalo Garcia Arraez, Samuel Rommelaere, Florent François Masson

Spiroplasma poulsonii is a vertically transmitted endosymbiont of Drosophila melanogaster that causes male-killing, that is the death of infected male embryos during embryogenesis. Here, we report a natural variant of S. poulsonii that is efficiently verti ...

WILEY2020

Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii

Bruno Lemaitre, Juan Camilo Paredes Escobar, Mario Gonzalo Garcia Arraez, Florent François Masson

BackgroundInsects frequently live in close relationship with symbiotic bacteria that carry out beneficial functions for their host, like protection against parasites and viruses. However, in some cases, the mutualistic nature of such associations is put in ...

2019

Genome Sequence of the Drosophila melanogaster Male-Killing Spiroplasma Strain MSRO Endosymbiont

Bruno Lemaitre, Ray Marcel Marin Florez, Jeremy Keith Herren, Juan Camilo Paredes Escobar

Spiroplasmas are helical and motile members of a cell wall-less eubacterial group called Mollicutes. Although all spiroplasmas are associated with arthropods, they exhibit great diversity with respect to both their modes of transmission and their effects o ...

American Society for Microbiology2015

Insect endosymbiont proliferation is limited by lipid availability

Bruno Lemaitre, Jeremy Keith Herren, Juan Camilo Paredes Escobar

Spiroplasma poulsonii is a maternally transmitted bacterial endosymbiont that is naturally associated with Drosophila melanogaster. S. poulsonii resides extracellularly in the hemolymph, where it must acquire metabolites to sustain proliferation. In this s ...

Elife Sciences Publications Ltd2014

The useful gate-crasher : molecular interactions between Drosophila and Spiroplasma

Juan Camilo Paredes Escobar

EPFL2014

Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery

Bruno Lemaitre, Jeremy Keith Herren, Juan Camilo Paredes Escobar, Fanny Schüpfer

Spiroplasma is a diverse bacterial clade that includes many vertically transmitted insect endosymbionts, including Spiroplasma poulsonii, a natural endosymbiont of Drosophila melanogaster. These bacteria persist in the hemolymph of their adult host and exh ...

American Society for Microbiology2013

Functional Analysis of PGRP-LA in Drosophila Immunity

Bruno Lemaitre, Nichole Broderick, Juan Camilo Paredes Escobar

PeptidoGlycan Recognition Proteins (PGRPs) are key regulators of the insect innate antibacterial response. Even if they have been intensively studied, some of them have yet unknown functions. Here, we present a functional analysis of PGRP-LA, an as yet unc ...

Public Library of Science2013

Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection

Bruno Lemaitre, David Welchman, Juan Camilo Paredes Escobar

Peptidoglycan recognition proteins (PGRPs) are key regulators of insect immune responses. In addition to recognition PGRPs, which activate the Toll and Imd pathways, the Drosophila genome encodes six catalytic PGRPs with the capacity to scavenge peptidogly ...

2011

Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function

Bruno Lemaitre, David Welchman, Juan Camilo Paredes Escobar

Peptidoglycan is an essential and specific component of the bacterial cell wall and therefore is an ideal recognition signature for the immune system. Peptidoglycan recognition proteins (PGRPs) are conserved from insects to mammals and able to bind PGN (no ...

Public Library of Science2011