Publications by Salif Axel Komi

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept

Auke Ijspeert, Léonie Asboth, Salif Axel Komi, Grégoire Courtine, Miroslav Caban, Nicolas Hankov, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Jocelyne Bloch, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Cathal John Harte

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. ...

AMER ASSOC ADVANCEMENT SCIENCE2025

System for control of spasticity

Salif Axel Komi, Grégoire Courtine, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Karen Minassian, Jocelyne Bloch

The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least o ...

2024

Walking naturally after spinal cord injury using a brain-spine interface

Léonie Asboth, Salif Axel Komi, Grégoire Courtine, Robin Jonathan Demesmaeker, Félix Antoine Martel, Laure Coquoz, Jocelyne Bloch, Anne Marie Lucienne Watrin, Sergio Daniel Hernandez, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Molywan Vat, Carmina Andrea Galvez Solano, Cathal John Harte, Valeria Spagnolo, Grégory Didier Dumont, Thibault Jean Etienne Collin, Icare Sakr, Lucas Struber

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

NATURE PORTFOLIO2023

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Léonie Asboth, Nawal Noëlle Kinany, Salif Axel Komi, Silvestro Micera, Grégoire Courtine, Miroslav Caban, Quentin Barraud, Marco Capogrosso, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Nathan Antoine Greiner, Jocelyne Bloch, Sergio Daniel Hernandez, Laura Ann McCracken, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Carmina Andrea Galvez Solano

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

The neurons that restore walking after paralysis

Léonie Asboth, Salif Axel Komi, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Katia Galan, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Kyungjin Kim, Thomas Haynes Hutson, Steven Lee Ceto

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Jérôme Gandar, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Salif Axel Komi, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Eduardo Martin Moraud, Marco Capogrosso, Mark Andrew Anderson, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Ileana Ozana Jelescu, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Laura Ann McCracken, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Jimmy James Ravier

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Electrical spinal cord stimulation protocols to regulate neurological functions after spinal cord injury

Salif Axel Komi

Spinal cord injury (SCI) is a life-changing event. People who suffer from it lose their ability to move normally and are subject to life-threatening symptoms. When the insult is not too severe, partial recovery is possible. Otherwise, for severely affected ...

EPFL2021

Targeted neurotechnology restores walking in humans with spinal cord injury

Vincent Delattre, Camille Georgette Marie Le Goff-Mignardot, Salif Axel Komi, Elvira Pirondini, Roman Heimgartner, Grégoire Courtine, Miroslav Caban, Joachim von Zitzewitz, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Karen Minassian, Esra Neufeld, Jocelyne Bloch, Ismael Seanez Gonzalez, Hendrik Lambert, Anne Marie Lucienne Watrin, Perrine Seguin, Laura Ann McCracken, Molywan Vat, Edoardo Paoles

2018