Publications by Maurizio Ferdinando Pezzoli

Of mice and men: Dendritic architecture differentiates human from mouse neuronal networks

Kathryn Hess Bellwald, Henry Markram, Rodrigo de Campos Perin, Alexis Arnaudon, Julie Meystre, Maurizio Ferdinando Pezzoli, Ying Shi, Lida Kanari, Natali Barros Zulaica

The organizational principles that distinguish the human brain from other species have been a long-standing enigma in neuroscience. Focusing on the uniquely evolved human cortical layers 2 and 3, we computationally reconstruct the cortical architecture for ...

2025

Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs

Maurizio Ferdinando Pezzoli, Ying Shi, Armando Romani, Michele Migliore, Rosanna Migliore

The fundamental role of any neuron within a network is to transform complex spatiotemporal synaptic input patterns into individual output spikes. These spikes, in turn, act as inputs for other neurons in the network. Neurons must execute this function acro ...

2023

Engram cell connectivity as a mechanism for information encoding and memory function

Maurizio Ferdinando Pezzoli

Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...

Cell Press2023

Neuronal growth on high-aspect-ratio diamond nanopillar arrays for biosensing applications

Niels Quack, Hilal Lashuel, Christophe Marcel Georges Galland, Maurizio Ferdinando Pezzoli, Somanath Jagannath, Hossein Babashah, Elena Losero

Monitoring neuronal activity with simultaneously high spatial and temporal resolution in living cell cultures is crucial to advance understanding of the development and functioning of our brain, and to gain further insights in the origin of brain disorders ...

Nature Portfolio2023

Engram cell connectivity: an evolving substrate for information storage

Maurizio Ferdinando Pezzoli, Siddhartha Sen

Understanding memory requires an explanation for how information can be stored in the brain in a stable state. The change in the brain that accounts for a given memory is referred to as an engram. In recent years, the term engram has been operationalized a ...

CURRENT BIOLOGY LTD2021

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Maurizio Ferdinando Pezzoli, Ying Shi, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Olivier Richard Hagens, Armando Romani, Christian Andreas Rössert, Michele Migliore, Szabolcs Kali, Carmen Alina Lupascu, Rosanna Migliore, Audrey Mercer, Luca Leonardo Bologna, Stefano Maximiliano Antonel

Every neuron is part of a network, exerting its function by transforming multiple spatiotemporal synaptic input patterns into a single spiking output. This function is specified by the particular shape and passive electrical properties of the neuronal memb ...

2018

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

Henry Markram, Johannes Le Coutre, Julie Meystre, Maurizio Ferdinando Pezzoli, Susana Camacho Romero

Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin r ...

Nature Publishing Group2015

Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices

Henry Markram, Johannes Le Coutre, Julie Meystre, Maurizio Ferdinando Pezzoli, Susana Camacho Romero, Sara Lillian Gonzalez Andino

Active ingredients of spices (AIS) modulate neural response in the peripheral nervous system, mainly through interaction with TRP channel/receptors. The present study explores how different AIS modulate neural response in layer 5 pyramidal neurons of S1 ne ...

Nature Publishing Group2014