Publications by Alexis Maximilien Bachmann

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Jean-David Horacio Morel, Ludger Jan Elzuë Goeminne, Sandra Rodriguez Lopez

Mice from different genetic backgrounds have widely diverse responses to the same metabolic challenges. Only PWK/PhJ mice show significant mitochondrial dysfunction and progression to fibrotic NASH that resembles human NASH. The PWK/PhJ strain is a novel N ...

ROCKEFELLER UNIV PRESS2023

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Dina Hofer, Yang Li, Jean-David Horacio Morel

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we ...

AMER SOC CLINICAL INVESTIGATION INC2023

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Alexis Rapin, Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Jean-David Horacio Morel, Xiaoxu Li

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Amir Banaei Esfahani, Karim Laurent Gariani, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Qingyao Huang, Laura Alejandra Velazquez Villegas, Yu Sun, Xiaoxu Li, Ludger Jan Elzuë Goeminne

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces, and plasma of 360 chowor high-fat-diet-fed BXD male mice and demonstrated th ...

Cell Press2022

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Jean-David Horacio Morel, Sandra Rodriguez Lopez, Jia Liu

WILEY2022

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

Alexis Maximilien Bachmann

Overweight and obesity are increasingly common public health issues worldwide, leading to a wide range of diseases from metabolic syndrome to steatohepatitis and cardiovascular diseases. While the increase in the prevalence of obesity is partly attributabl ...

EPFL2021