Bilge Eker

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Related publications (4)

Label-Free Recognition of Drug Resistance via Impedimetric Screening of Breast Cancer Cells

Philippe Renaud, Arnaud Bertsch, Robert Meissner, Bilge Eker

We present a novel study on label-free recognition and distinction of drug resistant breast cancer cells (MCF-7 DOX) from their parental cells (MCF-7 WT) via impedimetric measurements. Drug resistant cells exhibited significant differences in their dielect ...

Public Library of Science2013

A microfluidic-based frequency-multiplexing impedance sensor (FMIS)

Philippe Renaud, Arnaud Bertsch, Pierre Joris, Robert Meissner, Bilge Eker

We present a novel technology for the simultaneous and simple impedimetric screening of multiple microfluidic channels with only one electrode pair. We have exploited the frequency dimension to distinguish between up to three channels. Each ‘sub-sensor’ po ...

2012

Continuous and label-free toxicity screening of human hepatocytes on chip reveals frequency-dependant impedance profiles

Philippe Renaud, Robert Meissner, Bilge Eker

We present an electrical impedance based biosensor on a microfluidic cell culture platform that enables label-free and re- al-time investigation of drug toxicity-induced effects on hepatocytes. The temporal evolution of the impedance at different frequenci ...

2011

Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening

Philippe Renaud, Arnaud Bertsch, Sri Harsha Kasi Raj, Robert Meissner, Bilge Eker

We present a novel perfusion-based microfluidic platform for label-free drug toxicity screening which can single out non-lethal morphological changes from cellular death using electrical impedance spectroscopy. Minor cellular changes such as cell-cell cont ...

2011

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