Publications by Quy Ong Khac | EPFL Graph Search

Cholesterol-rich lipoprotein nanoparticles for cancer diagnosis

Francesco Stellacci, Quy Ong Khac, Lixia Wei

A method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject includes: (a) determining the protein level of at least one protein in the sample of isolated cholesterol-rich lipoprotein nanoparti ...

2025

Lyotropy as a Design Consideration for Ultra-Small Protein Nanoparticles via Electrohydrodynamic Jetting

Francesco Stellacci, Quy Ong Khac

Protein-based nanoparticles offer tailored bioactivity and biodegradability that are distinct from their synthetic polymeric counterparts. Precise engineering of physical properties, especially size, of nanoparticles using electrohydrodynamic (EHD) jetting ...

2025

Size distributions and fractograms of cholesterol-rich lipoprotein nanoparticles for cancer diagnosis

Francesco Stellacci, Quy Ong Khac, Lixia Wei

The present invention relates to a method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject comprising (α) determining the size distribution or the fractogram in chromatography of the cholest ...

2025

Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation

Francesco Stellacci, Quy Ong Khac, Xufeng Xu

In concentrated macromolecular dispersions, far-from-ideal intermolecular interactions determine the dispersion behaviors including phase transition, crystallization, and liquid-liquid phase separation. Here, we present a novel versatile capillary-cell des ...

Amer Chemical Soc2024

A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects

Armand Kurum, Francesco Stellacci, Quy Ong Khac, Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui, Li Tang, Lixia Wei, Yong Zhu, Francesca Olgiati

The activation of the host adaptive immune system is crucial for eliminating viruses. However, influenza infection often suppresses the innate immune response that precedes adaptive immunity, and the adaptive immune responses are typically delayed. Dendrit ...

Wiley-V C H Verlag Gmbh2024

Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles

Francesco Stellacci, Quy Ong Khac, Paulo Henrique Jacob Silva, Heyun Wang, Xufeng Xu, Rémi Andréa La Polla

We have learned from the recent COVID-19 pandemic that the emergence of a new virus can quickly become a global health burden and kill millions of lives. Antiviral drugs are essential in our fight against viral diseases, but most of them are virus-specific ...

Academic Press Inc Elsevier Science2023

Cryogenic electron tomography to determine thermodynamic quantities for nanoparticle dispersions

Davide Demurtas, Francesco Stellacci, Quy Ong Khac, Paulo Henrique Jacob Silva, Anna Murello, Ting Mao, Francesca Olgiati, Xufeng Xu

Here we present a method to extract thermodynamic quantities for nanoparticle dispersions in solvents. The method is based on the study of tomograms obtained from cryogenic electron tomography (cryoET). The approach is demonstrated for gold nanoparticles ( ...

2022

Experimental Method to Distinguish between a Solution and a Suspension

Francesco Stellacci, Quy Ong Khac, Paulo Henrique Jacob Silva, Ting Mao, Xufeng Xu

Dispersion of objects in a fluid phase can be classified as solutions (Gibbs free energy of mixing, Delta G(mix) < 0) or suspensions (Delta G(mix) > 0) depending on their thermodynamic stability. Small objects tend to form solutions, larger ones suspension ...

WILEY2022

Monovalent ion-mediated charge-charge interactions drive aggregation of surface-functionalized gold nanoparticles

Francesco Stellacci, Quy Ong Khac, Ting Mao, Francesca Olgiati

Monolayer-protected metal nanoparticles (NPs) are not only promising materials with a wide range of potential industrial and biological applications, but they are also a powerful tool to investigate the behaviour of matter at nanoscopic scales, including t ...

ROYAL SOC CHEMISTRY2022

In-situ Investigations on Gold Nanoparticles Stabilization Mechanisms in Biological Environments Containing HSA

Francesco Stellacci, Quy Ong Khac, Antonia Neels, Marianne Liebi

Nanoparticles (NPs) developments advance innovative biomedical applications. However, complex interactions and the low colloidal stability of NPs in biological media restrict their widespread utilization. The influence of NPs properties on the colloidal st ...

WILEY-V C H VERLAG GMBH2021

Chemical sensing with Au and Ag nanoparticles

Francesco Stellacci, Quy Ong Khac, Marta Diez Castellnou

Noble metal nanoparticles (NPs) are ideal scaffolds for the fabrication of sensing devices because of their high surface-to-volume ratio combined with their unique optical and electrical properties which are extremely sensitive to changes in the environmen ...

Royal Society of Chemistry2021

Multi-sulfonated ligands on gold nanoparticles as virucidal antiviral for Dengue virus

Francesco Stellacci, Quy Ong Khac, Özgün Kocabiyik

Dengue virus (DENV) causes 390 million infections per year. Infections can be asymptomatic or range from mild fever to severe haemorrhagic fever and shock syndrome. Currently, no effective antivirals or safe universal vaccine is available. In the present w ...

Nature Research2020

Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture

Francesco Stellacci, Quy Ong Khac, Zhi Luo, Ahmet Bekdemir

Reproducibility of results is essential for a well-designed and conducted experiment. Several reasons may originate failure in reproducing data, such as selective reporting, low statistical power, or poor analysis. In this study, we used PEG6000 samples fr ...

2020

Thioether-Functionalized Quinone-Based Resorcin[4]arene Cavitands: Electroswitchable Molecular Actuators

Nils Trapp, Quy Ong Khac, Jovana Milic, Thomas Schneeberger

The utility of molecular actuators in nanoelectronics requires activation of mechanical motion by electric charge at the interface with conductive surfaces. We functionalized redox-active resorcin[4]arene-quinone cavitands with thioethers as surface-anchor ...

2019

Stable Ultraconcentrated and Ultradilute Colloids of CsPbX3 (X = Cl, Br) Nanocrystals Using Natural Lecithin as a Capping Ligand

Francesco Stellacci, Quy Ong Khac

Attaining thermodynamic stability of colloids in a broad range of concentrations has long been a major thrust in the field of colloidal ligand-capped semiconductor nanocrystals (NCs). This challenge is particularly pressing for the novel NCs of cesium lead ...

AMER CHEMICAL SOC2019

Determination and evaluation of the nonadditivity in wetting of molecularly heterogeneous surfaces

Francesco Stellacci, Quy Ong Khac, Sylvie Roke, Zhi Luo, Michele Ceriotti, Filip Kovacik, David Mark Wilkins, Halil Ibrahim Okur, Anna Murello

The interface between water and folded proteins is very complex. Proteins have "patchy" solvent-accessible areas composed of domains of varying hydrophobicity. The textbook understanding is that these domains contribute additively to interfacial properties ...

National Academy of Sciences2019

Multidimensional Characterization of Mixed Ligand Nanoparticles Using Small Angle Neutron Scattering

Francesco Stellacci, Quy Ong Khac, Stefan Guldin, Zhi Luo, Ye Yang

The properties of ligand protected gold nanoparticles are determined by the synergistic interplay of their structural components, including the metal core, the ligand shell, and the solvation layer. However, the simultaneous characterization of all these c ...

AMER CHEMICAL SOC2019

Quantitative 3D determination of self-assembled structures on nanoparticles using small angle neutron scattering

Francesco Stellacci, Quy Ong Khac, Zhi Luo, Raffaella Buonsanti, Anna Loiudice

2018

Novel Sensing Strategies Based on Monolayer Protected Gold Nanoparticles for the Detection of Metal Ions and Small Molecules

Francesco Stellacci, Quy Ong Khac, Elif Ertem Bekdemir, Marta Diez Castellnou

2018

Bimodal atomic force microscopy for the characterization of thiolated self-assembled monolayers

Francesco Stellacci, Quy Ong Khac, Nikolaos Nianias, Evangelia-Nefeli Athanasopoulou

Surface coatings are becoming an integral part of materials. In recent years, molecular coatings have found larger acceptance and uses. Among them, self-assembled monolayers (SAMs) are attractive due to their inherent versatility, manufacturability, and sc ...

ROYAL SOC CHEMISTRY2018