Publications by Melissa Saenz | EPFL Graph Search

High-Resolution fMRI of Auditory Cortical Map Changes in Unilateral Hearing Loss and Tinnitus

Stephanie Clarke, Dimitri Nestor Alice Van De Ville, Wietske Van der Zwaag, Naghmeh Ghazaleh, Melissa Saenz

Animal models of hearing loss and tinnitus observe pathological neural activity in the tonotopic frequency maps of the primary auditory cortex. Here, we applied ultra high-field fMRI at 7 T to test whether human patients with unilateral hearing loss and ti ...

Springer Verlag2017

Neural Decoding of Discriminative Auditory Object Features Depends on Their Socio-Affective Valence

Wietske Van der Zwaag, Melissa Saenz

Human voices consist of specific patterns of acoustic features that are considerably enhanced during affective vocalizations. These acoustic features are presumably used by listeners to accurately discriminate between acoustically or emotionally similar vo ...

Oxford University Press (OUP)2016

Study of tonotopic brain changes with functional MRI and FDG-PET in a patient with unilateral objective cochlear tinnitus

Melissa Saenz

We studied possible brain changes with functional MRI (fMRI) and fluorodeoxyglucose positron emission tomography (FDG-PET) in a patient with a rare, high-intensity "objective tinnitus" (high-level SOAEs) in the left ear of 10 years duration, with no associ ...

Elsevier2016

Representation of Sound Objects within Early-Stage Auditory Areas: A Repetition Effect Study Using 7T fMRI

Stephanie Clarke, Wietske Van der Zwaag, Melissa Saenz

Environmental sounds are highly complex stimuli whose recognition depends on the interaction of top-down and bottom-up processes in the brain. Their semantic representations were shown to yield repetition suppression effects, i. e. a decrease in activity d ...

Public Library of Science2015

Tonotopic Gradients in Human Primary Auditory Cortex: Concurring Evidence From High-Resolution 7 T and 3 T fMRI

Stephanie Clarke, Wietske Van der Zwaag, Melissa Saenz

The tonotopic representations within the primary auditory cortex (PAC) have been successfully mapped with ultra-high field fMRI. Here, we compared the reliability of this tonotopic mapping paradigm at 7 T with 1.5 mm spatial resolution with maps acquired a ...

Springer2015

Tonotopic mapping of human auditory cortex

Melissa Saenz

Since the early days of functional magnetic resonance imaging (fMRI), retinotopic mapping emerged as a powerful and widely-accepted tool, allowing the identification of individual visual cortical fields and furthering the study of visual processing. In con ...

Elsevier2014

Tuning In to Sound: Frequency-Selective Attentional Filter in Human Primary Auditory Cortex

Stephanie Clarke, Wietske Van der Zwaag, Melissa Saenz

Cocktail parties, busy streets, and other noisy environments pose a difficult challenge to the auditory system: how to focus attention on selected sounds while ignoring others? Neurons of primary auditory cortex, many of which are sharply tuned to sound fr ...

Society for Neuroscience2013

Human Primary Auditory Cortex Follows the Shape of Heschl's Gyrus

Stephanie Clarke, Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques, Melissa Saenz

The primary auditory cortex (PAC) is central to human auditory abilities, yet its location in the brain remains unclear. We measured the two largest tonotopic subfields of PAC (hA1 and hR) using high-resolution functional MRI at 7 T relative to the underly ...

Society for Neuroscience2011