Publications by Michele De Palma

Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT

Pascal Fua, Michele De Palma, Nahal Mansouri, Jakub Jan Gwizdala

BackgroundBronchiolitis Obliterans Syndrome (BOS), a fibrotic airway disease that may develop after lung transplantation, conventionally relies on pulmonary function tests (PFTs) for diagnosis due to limitations of CT imaging. Deep neural networks (DNNs) h ...

SPRINGERNATURE2025

Red Listing African Goliath Beetles: Assessing Threats and Conservation Needs

Michele De Palma

The loss of biodiversity is one of the most critical global environmental challenges, driven by deforestation, habitat fragmentation and overexploitation. This study focuses on the biodiversity crisis in Africa, with particular emphasis on the conservation ...

2025

Trajectories of macrophage ontogeny and reprogramming in cancer

Michele De Palma, Céline Wyser Rmili, Gael Luis Boivin, Alan Nicolas Thierry Guichard, Nahal Mansouri

Tumor-associated macrophages (TAMs) often manifest immunosuppressive and tumor-promoting phenotypes contributing to immunotherapy resistance. Dicer1 inactivation in TAMs (DKO) prompts their immunostimulatory activation, enabling effective immunotherapy in ...

2025

Taxonomic revision of Mecynorhina Hope, 1837 and allied African genera with simple or bifurcate horns (Coleoptera, Scarabaeidae, Cetoniinae, Goliathini)

Michele De Palma

We conducted morphological and DNA barcoding analyses of representative taxa in the Mecynorhina Hope, 1837 species-complex (type species: Scarabaeus polyphemus Fabricius, 1781), which had been split into five subgenera by DE PALMA & FRANTZ (2010). Subgenus ...

2024

Revisional notes on the subgenus Stephanorrhina (Aphelorrhina) Westwood, 1843 (Coleoptera, Scarabaeidae, Cetoniinae)

Michele De Palma

The subgenus Stephanorrhina (Aphelorrhina) Westwood, 1843 is studied and revised. The analysis of type material and original descriptions has revealed a number of misidentifications, which are corrected herein. S. (A.) haroldi Kolbe 1892 bona sp. is reinst ...

2024

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Michele De Palma

We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit a ...

Nature Portfolio2024

Search for high-mass exclusive diphoton production with tagged protons in proton-proton collisions at √s=13 TeV

Patrick Berger, Rakesh Chawla, Ian Smith, Jung Eung Park, Thomas Mountford, Matthias Finger, Matteo Galli, Maria Isabel Cordero Campana, Xiaoqiang Wang, Jian Zhao, James Gonzalo King, Mirko Kovac, Hua Zhang, Joo Yeon Kim, Jae-Woo Choi, Pedro Camilo de Oliveira e Silva, Young Min Kim, Myun Sik Kim, Gabriele Grosso, Qian Wang, Varun Sharma, Michele De Palma, Hyungjun Lee, Chia-Chun Chen, Siyuan Wang, Özdemir Can Kara, Shivom Sharma, Jian Wang, Yi Zhang, Bokyoung Kim, Rahul Kumar Gupta, Ling Zhou, Mithlesh Kumar, Chenyang Wang, Matthias Wolf, Chang-Hyun Park, Anna Mascellani, Yikai Yang, Zhenyu Wang, Seonwoo Lee, Wei-Hsiang Lin, , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Milestones in tumor vascularization and its therapeutic targeting

Douglas Hanahan, Michele De Palma

Research into the mechanisms and manifestations of solid tumor vascularization was launched more than 50 years ago with the proposition and experimental demonstrations that angiogenesis is instrumental for tumor growth and was, therefore, a promising thera ...

Nature Portfolio2024

Living With Hyraxes: Biogeography and Comparative Ecology of West African Fornasinius Beetles

Michele De Palma

Among the flower beetles (Scarabaeidae, Cetoniinae), the Goliathini comprise several genera of medium- and large-sized beetles widely distributed in sub-Saharan Africa. In this tribe, the genus Fornasinius Bertoloni, 1853, includes two species found in Wes ...

Wiley2024

CYTOKINE-ARMORED DENDRITIC CELL PROGENITORS SYNERGIZE WITH CAR-T CELLS IN SOLID TUMORS

Michele De Palma, Ali Ghasemi, Amaia Martinez Usatorre

Mary Ann Liebert, Inc2023

A remarkable new Agestrata Eschscholtz, 1829 from Myanmar (Coleoptera, Scarabaeidae, Cetoniinae)

Michele De Palma

A new species in the genus Agestrata Eschscholtz, 1829 is described from Myanmar. The new taxon, Agestrata fortii n. sp., is markedly different from the other members of the genus. Further to the uniform turquoise-cerulean blue color of the integument, A. ...

2023

Basophils inhibit tumors by suppressing Tregs

Michele De Palma, Bruno Torchia, Nahal Mansouri, Simge Yücel

European Respiratory Soc Journals Ltd2023

HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia

Michele De Palma, Mario Leonardo Squadrito

Use of autologous cells isolated from elderly patients with multiple comorbidities may account for the modest efficacy of cell therapy in patients with chronic limb threatening ischemia (CLTI). We aimed to determine whether proarteriogenic monocyte/macroph ...

Amer Soc Clinical Investigation Inc2023

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Michele De Palma, Bruno Torchia, Alan Nicolas Thierry Guichard, Yahya Mohammadzadeh, Ali Ghasemi, Nahal Mansouri

Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical re ...

Nature Portfolio2023

Engineered progenitor cells and methods of use

Michele De Palma, Ali Ghasemi, Amaia Martinez Usatorre

Disclosed herein are engineered progenitor cells and methods of using the same. Also disclosed herein are engineered cells differentiated from engineered progenitor cells of the present disclosure. Also disclosed herein are methods of treating a condition ...

2023

Medical and Personal Characteristics Can Predict the Risk of Lung Metastasis

Michele De Palma, Nahal Mansouri

Aims: Understanding the correlations between underlying medical and personal characteristics of a patient with cancer and the risk of lung metastasis may improve clinical management and outcomes. We used machine learning methodologies to predict the risk o ...

2023

Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report

Michele De Palma, Ferdinando Pucci, Qin Zhang

Extracellular vesicles (EVs) are small, lipid-bilayer-bound particles released by cells that can contain important bioactive molecules, including lipids, RNAs, and proteins. Once released in the extracellular environment, EVs can act as messengers locally ...

WILEY2023

Defining and targeting tumor-associated macrophages in malignant mesothelioma

Michele De Palma

Defining the ontogeny of tumor-associated macrophages (TAM) is important to develop therapeutic targets for mesothelioma. We identified two distinct macrophage populations in mouse peritoneal and pleural cavities, the monocyte-derived, small peritoneal/ple ...

National Academy of Sciences2023

A new Hypselogenia Burmeister, 1840 from Angola (Coleoptera, Scarabaeidae, Cetoniinae, Goliathini)

Michele De Palma

Morphological and DNA barcoding analysis identify a new species in the Afrotropical genus Hypselogenia Burmeister, 1840. Hypselogenia hassoni sp. nov. is described from the Cuanza Sul Province of Angola. The new species belongs to the Hypselogenia geotrupi ...

2022

A new Analleucosma Antoine, 1989 from West Africa (Coleoptera, Scarabaeidae, Cetoniinae)

Michele De Palma

The genus Analleucosma Antoine, 1989 is known from northeastern and southeastern Democratic Republic of Congo and a few localities in East Africa; it currently comprises three similar species, all very scarce in collections. Here I describe a new species, ...

2022