Publications by Marco Cassano | EPFL Graph Search

KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity

Didier Trono, Annamaria Kauzlaric, Marco Cassano, Suk Min Jang, Evaristo Jose Planet Letschert

KAP1 (KRAB-associated protein 1) is best known as a co-repressor responsible for inducing heterochromatin formation, notably at transposable elements. However, it has also been observed to bind the transcription start site of actively expressed genes. To a ...

2020

Inflammation and Microbiota Fingerprint: Delphi's Oracle for Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma?

Marco Cassano

WILEY2019

ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Carine Delattre-Gubelmann, Didier Trono, Julien Léonard Duc, Bart Deplancke, Sunil Kumar Raghav, Marco Cassano, Michaël Imbeault, Petra Catalina Schwalie, Suk Min Jang, Riccardo Dainese, Julie Marie Russeil, Wanze Chen, Evgeniia Pankevich

Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revea ...

Nature Research2019

Pharmacological induction of a progenitor state for the efficient expansion of primary human hepatocytes

Matthias Lütolf, Didier Trono, Nathalie Brandenberg, Marc Samuel Friedli, Marco Cassano, Carmen Maria Unzu Ezquerro, Evaristo Jose Planet Letschert

The liver is an organ with strong regenerative capacity, yet primary hepatocytes have a low amplification potential in vitro, a major limitation for the cell-based therapy of liver disorders and for ex vivo biological screens. Induced pluripotent stem cell ...

2019

Polyphenic trait promotes liver cancer in a model of epigenetic instability

Didier Trono, Sandra Eloise Kjeldsen, Marco Cassano, Alessandra Piersigilli, Suk Min Jang, Evaristo Jose Planet Letschert

Hepatocellular carcinoma (HCC) represents the fifth most common form of cancer worldwide and carries a high mortality rate due to lack of effective treatment. Males are eight times more likely to develop HCC than females, an effect largely driven by sex ho ...

Wiley-Blackwell2017

The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units

Didier Trono, Annamaria Kauzlaric, Julien Léonard Duc, Gabriela Ecco, Marco Cassano, Michaël Imbeault

KRAB-containing poly-zinc finger proteins (KZFPs) constitute the largest family of transcription factors encoded by mammalian genomes, and growing evidence indicates that they fulfill functions critical to both embryonic development and maintenance of adul ...

Public Library of Science2017

Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

Didier Trono, Priscilla Turelli, Annamaria Kauzlaric, Julien Léonard Duc, Helen Mary Rowe, Sandra Eloise Kjeldsen, Gabriela Ecco, Marco Cassano, Michaël Imbeault, Andrea Coluccio

KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of transposable elements (TEs), which they repress with their cofactor KAP1 through histone and DNA methylation, a process thought to result in irreversible silencing. Using a ...

Cell Press - Elsevier2016

Cardiac Niche Influences the Direct Reprogramming of Canine Fibroblasts into Cardiomyocyte-Like Cells

Marco Cassano

The Duchenne and Becker muscular dystrophies are caused by mutation of dystrophin gene and primarily affect skeletal and cardiac muscles. Cardiac involvement in dystrophic GRMD dogs has been demonstrated by electrocardiographic studies with the onset of a ...

Hindawi Limited2016

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

Didier Trono, Isabelle Barde, Adamantia Kapopoulou, Benjamin Rauwel, Marco Cassano, Suk Min Jang

Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are normally controlled by the immune system, but can be fat ...

2015

A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

Didier Trono, Marco Cassano, Suk Min Jang, Evaristo Jose Planet Letschert

The transcriptional activator MyoD serves as a master controller of myogenesis. Often in partnership with Mef2 (myocyte enhancer factor 2), MyoD binds to the promoters of hundreds of muscle genes in proliferating myoblasts yet activates these targets only ...

Cold Spring Harbor Lab Press, Publications Dept2015

Molecular and cell-based therapies for muscle degenerations: a road under construction

Marco Cassano, Stefania Crippa

Despite the advances achieved in understanding the molecular biology of muscle cells in the past decades, there is still need for effective treatments of muscular degeneration caused by muscular dystrophies and for counteracting the muscle wasting caused b ...

Frontiers Research Foundation2014

Myogenic potential of canine craniofacial satellite cells

Marco Cassano

The skeletal fibers have different embryological origin; the extraocular and jaw-closer muscles develop from prechordal mesoderm while the limb and trunk muscles from somites. These different origins characterize also the adult muscle stem cells, known as ...

Frontiers Research Foundation2014

Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma

Kai Johnsson, Didier Trono, Karolina Bojkowska, Francesca Santoni de Sio, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Nadine Fournier, Cristina Cartoni, Marco Cassano, Fabio Aloisio

Wiley-Blackwell2012