Publications by Benjamin Samuel Murray

Recent progress in the development of organometallics for the treatment of cancer

Paul Joseph Dyson, Benjamin Samuel Murray

From their early successes in medicine, organometallic compounds continue to attract interest as potential chemotherapeutics to treat a range of diseases. Here, we show from recent literature selected largely from the last two years that organometallics of ...

2019

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

Paul Joseph Dyson, Benjamin Samuel Murray, Tina Riedel

The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous ...

Nature Research2017

An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode

Paul Joseph Dyson, Ursula Röthlisberger, Thibaud Edouard Alistair von Erlach, Giulia Palermo, Benjamin Samuel Murray

Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions. Many different intercalator compounds have been studied because of their activity as mutagens or drugs ...

Wiley-VCH Verlag GmbH2016

The development of RAPTA compounds for the treatment of tumors

Paul Joseph Dyson, Christian Hartinger, Benjamin Samuel Murray

Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has b ...

Elsevier Science Sa2016

Potential of Cycloaddition Reactions To Generate Cytotoxic Metal Drugs In Vitro

Paul Joseph Dyson, Stéphanie Crot, Benjamin Samuel Murray, Sviatlana Siankevich

Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s). Toward this aim, we report the devel ...

Amer Chemical Soc2014

Highly cytotoxic trithiolato-bridged dinuclear Rh(III) and Ir(III) complexes

Paul Joseph Dyson, Benjamin Samuel Murray

Water soluble trithiolato-bridged cationic complexes of the type (eta(5)-C5Me5)(2)M-2(mu-SC6H4-p-X)(3) (M = Rh, X = H, 1; CH3, 3; OCH3, 5; Pr-i, 7; Bu-t, 9; M Ir, X = H, 2; CH3, 4; OCH3, 6; Pr-i, 8; Bu-t, 10) were synthesized and isolated as their chl ...

Elsevier Science Sa2014

Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics

Rosario Scopelliti, Paul Joseph Dyson, Laure Menin, Benjamin Samuel Murray

Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative conformati ...

2014

Antiproliferative activities of trithiolato-bridged dinuclear arene osmium complexes

Paul Joseph Dyson, Benjamin Samuel Murray

Trithiolato-bridged arene osmium complexes of the general formula (p-cymene)(2)Os-2(mu-SR)(3) (R = C6H5, 1; C6H4-p-Me, 2; C6H4-p-OMe, 3; C6H4-p-Pr-i, 4; C6H4-p-But, 5; CH2C6H5, 6; CH2CH2C6H5, 7; CH2C6H4-p-Bu-t, [8](+ ...

Elsevier Science Sa2014

Synthesis, molecular structure, computational study and in vitro anticancer activity of dinuclear thiolato-bridged pentamethylcyclopentadienyl Rh(III) and Ir(III) complexes

Paul Joseph Dyson, Benjamin Samuel Murray

Neutral dinuclear dithiolato-bridged pentamethylcyclopentadienyl Rh(III) complexes of the type (C5Me5)(2)Rh-2(mu-SR)(2)Cl-2 (R = CH2Ph, 1; R = CH2CH2Ph, 2) and cationic dinuclear trithiolato-bridged pentamethylcyclopentadienyl Rh(III) and Ir(III) complexes ...

Royal Society of Chemistry2013

Synthesis, Molecular Structure and Cytotoxicity of Molecular Materials Based on Water Soluble Half-Sandwich Rh(III) and Ir(III) Tetranuclear Metalla-Cycles

Paul Joseph Dyson, Benjamin Samuel Murray

The neutral dinuclear complexes [(eta(5)-C5Me5)(2)Rh-2(mu-dhnq)Cl-2] (1) and [(eta(5)-C5Me5)(2)Ir-2(mu-dhnq)Cl-2] (2) (dhnqH(2) = 5,8-dihydroxy-1,4-naphthoquinone) were obtained from the reaction of (eta(5)-C5Me5)M(mu-Cl)Cl (M = Rh, Ir) with dhnqH(2) ...

2013