Publications by Reto Frei | EPFL Graph Search

General and Practical Formation of Thiocyanates from Thiols

Matthew Wodrich, Jérôme Waser, Reto Frei, Thibaut Christian Courant

A new method for the cyanation of thiols and disulfides using cyanobenziodoxol(on)e hypervalent iodine reagents is described. Both aliphatic and aromatic thiocyanates can be accessed in good yields in a few minutes at room temperature starting from a broad ...

Wiley-Blackwell2015

Proteome-Wide Profiling of Targets of Cysteine reactive Small Molecules by Using Ethynyl Benziodoxolone Reagents

Jérôme Waser, Chao Wang, Reto Frei, Durga Prasada Rao Hari

In this study, we present a highly efficient method for proteomic profiling of cysteine residues in complex proteomes and in living cells. Our method is based on alkynylation of cysteines in complex proteomes using a clickable alkynyl benziodoxolone bearin ...

Wiley-Blackwell2015

Performance of the LHCb Vertex Locator

Aurelio Bay, Guido Haefeli, Olivier Schneider, Matthew Needham, Barinjaka Rakotomiaramanana, Reto Frei, Mark Tobin, Jian Wang

The Vertex Locator (VELO) is a silicon microstrip detector that surrounds the proton-proton interaction region in the LHCb experiment. The performance of the detector during the first years of its physics operation is reviewed. The system is operated in va ...

Iop Publishing Ltd2014

Taming Hypervalent Bonds and Strained Rings for Catalysis and Synthesis

Jérôme Waser, Florian Patrick Marie Daniel De la Barre De Nanteuil, Sophie Lucie Racine, Maria Victoria Vita, Yifan Li, Reto Frei, Eloísa Sofía Serrano Robledo

Improving the synthesis of complex organic molecules is essential for progress in many fields such as medicine, agrochemicals or materials. Since 2007, our laboratory has been focusing on the development of non-classical bond disconnections based on the us ...

2014

Cyclization and annulation reactions of nitrogen-substituted cyclopropanes and cyclobutanes

Jérôme Waser, Filippo De Simone, Fides Benfatti, Florian Patrick Marie Daniel De la Barre De Nanteuil, Reto Frei, Eloísa Sofía Serrano Robledo

Cyclization and annulation reactions initiated by ring-opening of small rings, especially cyclopropanes and cyclobutanes are now well-established in synthetic chemistry. Nevertheless, the potential of aminocyclopropanes and cyclobutanes, an important subcl ...

Royal Society of Chemistry2014

Fast and Highly Chemoselective Alkynylation of Thiols with Hypervalent Iodine Reagents Enabled through a Low Energy Barrier Concerted Mechanism

Matthew Wodrich, Jérôme Waser, Reto Frei, Durga Prasada Rao Hari

Among all functional groups, alkynes occupy a privileged position in synthetic and medicinal chemistry, chemical biology, and materials science. Thioalkynes, in particular, are highly useful, as they combine the enhanced reactivity of the triple bond with ...

2014

Introducing the CTA concept

Christophe Bauer, Francisco Sanchez, Michael Werner, Mathieu Ribordy, Munehito Kagaya, Steve Couturier, Xiaoqing Zhou, Thomas Günther Bretz, Reto Frei, Etienne Antoine Julien Moulin, Bruno Garcia, Werner Lustermann

The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span abou ...

Elsevier Science Bv2013

A Highly Chemoselective and Practical Alkynylation of Thiols

Jérôme Waser, Reto Frei

A thiol-alkynylation procedure utilizing the hypervalent iodine alkyne transfer reagent TIPS-ethynyl-benziodoxolone has been developed. This scalable reaction proceeds in five minutes at room temperature in an open flask using commercially available reagen ...

American Chemical Society2013

Acoustic resonant sensor for ultra high energy neutrino detection

Mathieu Ribordy, Reto Frei

The characterization of the cosmogenic neutrino flux would give insights into cosmological source evolution, source spectra and composition at injection, through the partial recovery of the degraded information carried by the ultra high energy cosmic rays. ...

2011

Performance of the LHCb Silicon Tracker in p-p Collisions at the LHC

Christophe Salzmann, Aurelio Bay, Minh Tâm Tran, Neal Gauvin, Géraldine Conti, Christophe Bauer, Joël Bressieux, Vincent Fave, Johan Luisier, Tatsuya Nakada, Guido Haefeli, Mathias Oleg Knecht, Olivier Schneider, Frédéric Guillaume Dupertuis, Anne Keune, Frédéric Blanc, Matthew Needham, Raluca Anca Muresan, Reto Frei, Mark Tobin, Michel De Cian

The Large Hadron Collider beauty experiment (LHCb) is a single-arm forward spectrometer dedicated to the study of B-meson decays in p - p collisions at the Large Hadron Collider (LHC). The LHCb detector has excellent tracking and particle identification ca ...

Ieee2011

LHCb Silicon Tracker DAQ and ECS Online Systems

Christophe Salzmann, Aurelio Bay, Minh Tâm Tran, Aurélie Perrin, Marc-Olivier Bettler, Louis Nicolas, Cédric Potterat, Géraldine Conti, Christophe Bauer, Vincent Fave, Johan Luisier, Tatsuya Nakada, Guido Haefeli, Mathias Oleg Knecht, Olivier Schneider, Anne Keune, Frédéric Blanc, Matthew Needham, Raluca Anca Muresan, Reto Frei, Mark Tobin

The LHCb experiment at CERN is designed to perform precision measurements of b quark decays. The Silicon Tracker plays a crucial role in reconstructing particle trajectories and consists of two silicon micro-strip detectors, the Tracker Turicensis and the ...

2010

The LHCb VELO analogue transmission line

Jérémie Borel, Aurelio Bay, Guido Haefeli, Laurent Locatelli, Olivier Schneider, Reto Frei

The Vertex Locator is one of the most important sub-detectors of the LHCb experiment, which is devoted to B physics. The signals from the silicon strip sensors are multiplexed at 40 MHz and transported by 60 m copper lines to the counting stations placed i ...

2010

LHCb Silicon Tracker Performance Studies

Aurelio Bay, Minh Tâm Tran, Christophe Bauer, Sergio Jiménez-Otero, Matthew Needham, Reto Frei

2006