Publications by Grégoire Courtine

Diagnosis and management of orthostatic hypotension in synucleinopathies Diagnostic et prise en charge des hypotensions orthostatiques en cas de synucléinopathies

Synucleinopathies are frequently associated with non-motor symptoms such as orthostatic hypotension, which directly impacts patients’ quality of life and requires effective management by general practitioners and neurologists. This management involves drug ...

2025

A neuromechanics solution for adjustable robot compliance and accuracy

Auke Ijspeert, Grégoire Courtine

Robots have to adjust their motor behavior to changing environments and variable task requirements to successfully operate in the real world and physically interact with humans. Thus, robotics strives to enable a broad spectrum of adjustable motor behavior ...

AMER ASSOC ADVANCEMENT SCIENCE2025

Neurosurgical therapies for movement disorders in 2025 Thérapies neurochirurgicales dans les troubles du mouvement en 2025

Grégoire Courtine

For several decades, deep brain stimulation has been a major breakthrough in the treatment of movement disorders, significantly improving the quality of life of patients with Parkinson’s disease, but also with dystonia or tremor. Thanks to technological ad ...

2025

A clinical road map for single-cell omics

Grégoire Courtine, Jocelyne Bloch

In a matter of years, single-cell omics has matured from a pioneering technique employed by just a handful of specialized laboratories to become a ubiquitous feature of biological research and a key driver of scientific discovery. The widespread adoption a ...

2025

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept

Auke Ijspeert, Léonie Asboth, Salif Axel Komi, Grégoire Courtine, Miroslav Caban, Nicolas Hankov, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Jocelyne Bloch, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Cathal John Harte

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. ...

AMER ASSOC ADVANCEMENT SCIENCE2025

A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy

Grégoire Courtine, Newton Cho, Jordan Squair

Teravoxel-scale, cellular-resolution images of cleared rodent brains acquired with light-sheet fluorescence microscopy have transformed the way we study the brain. Realizing the potential of this technology requires computational pipelines that generalize ...

NATURE PORTFOLIO2025

Regional specialization of movement encoding across the primate sensorimotor cortex

Tomislav Milekovic, Grégoire Courtine, Simon Borgognon, Jocelyne Bloch, Ismael Seanez Gonzalez, Nicolò Macellari

The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across ...

Springer Science and Business Media LLC2025

Role and modulation of various spinal pathways for human upper limb control in different gravity conditions

Auke Ijspeert, Grégoire Courtine

Humans can perform movements in various physical environments and positions (corresponding to different experienced gravity), requiring the interaction of the musculoskeletal system, the neural system and the external environment. The neural system is itse ...

2025

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Bernard Schneider, Grégoire Courtine, Quentin Barraud, Michael V. Sofroniew, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Matthieu Pierre Gautier, Thomas Haynes Hutson, Michael Alexander Skinnider

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

Springer Science and Business Media LLC2024

System for control of spasticity

Salif Axel Komi, Grégoire Courtine, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Karen Minassian, Jocelyne Bloch

The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least o ...

2024

Best practices for differential accessibility analysis in single-cell epigenomics

Grégoire Courtine, Jordan Squair, Michael Alexander Skinnider

Differential accessibility (DA) analysis of single-cell epigenomics data enables the discovery of regulatory programs that establish cell type identity and steer responses to physiological and pathophysiological perturbations. While many statistical method ...

Nature Research2024

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

Grégoire Courtine, Jordan Squair, Markus Maximilian Rieger

Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARCEX Therapy to improve a ...

Nature Portfolio2024

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Léonie Asboth, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Nicolas Hankov, Katia Galan, Robin Jonathan Demesmaeker, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Matthieu Pierre Gautier, Jimmy James Ravier, Thomas Haynes Hutson, Viviana Aureli

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Neuromodulation/neurostimulation system for controlling a respiratory function

Vincent Delattre, Léonie Asboth, Grégoire Courtine, Miroslav Caban, Nicolas Hankov, Robin Jonathan Demesmaeker, Jocelyne Bloch

The present invention relates to a neuromodulation/neurostimulation system for supporting and/or controlling a function of t he respiratory system of a patient, said function comprising a plurality of phases each involving one or more muscles. The system c ...

2024

System for micturition control in a mammal with bladder disfunction

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Loïs Thomas Romain Mahe

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

2024

Neuromodulation/neurostimulation system for restoring a motor function and facilitating neurological recovery

Grégoire Courtine, Jocelyne Bloch, Henri Charles Alexandre Lorach

The present invention relates to a neuromodulation/neurostimulation system (100) for restoring a motor function of the upper and/or lower limbs and facilitating neurological recovery in a patient (P) with spinal cord injury (SCI) and/or other neurological ...

2024

Early intensive rehabilitation reverses locomotor disruption, decrease brain inflammation and induces neuroplasticity following experimental Cerebral Palsy

Yohan Van de Looij, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud

Background: Cerebral Palsy (CP) is a major cause of motor and cognitive disability in children due to injury to the developing brain. Early intensive sensorimotor rehabilitation has been shown to change brain structure and reduce CP symptoms severity. We c ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2024

Magnesium Test: Universal and Ultra-Sensitive Method for Measuring Reliability of Thin-Film-Encapsulated Bioelectronic Implants in Physiological Environment

Yves Leterrier, Stéphanie Lacour, Grégoire Courtine, Lei Wang, Ivan Furfaro, Claudia Kathe, Kangling Wu, Massimo Mariello

Next-generation bioelectronic implants require miniaturization, durability, and long-term functionality. Thin film encapsulations, prepared with inorganic or hybrid organic/inorganic designs, are essential for ensuring protection, low water permeation, ada ...

Wiley-V C H Verlag Gmbh2024

Neurotrauma treatment

Bernard Schneider, Grégoire Courtine, Mark Andrew Anderson, Jordan Squair

The invention provides pharmaceutical compositions, combinations and vectors, such as expression vectors, as well as use thereof in a method for central nervous system repair after neurotrauma, such as spinal cord injury (SCI) or stroke and in a method for ...

2024

A spinal neuroprosthesis against locomotor deficits in Parkinson's disease

Grégoire Courtine, Jocelyne Bloch

Edp Sciences S A2024