Publications by Rodrigo Araujo Fraga Da Silva

Local Shear Stress and Dyslipidemia Interfere with Actin Cyto-Skeleton and Lysosomal Organization Contributing to Vascular Fragility

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Shear stress is one of the major hemodynamic forces acting on the endothelium. However, it is not well known how endothelial cells (EC) respond mechanically to these stimuli in vivo. Here we investigated whether changes in biomechanics properties and shear ...

2024

MOSAIC on the ELT: Front-End and instrument AITV planification

Dominique Chapuis, Rodrigo Araujo Fraga Da Silva

MOSAIC is the Multi-Object Spectrograph for the ESO-ELT (European Southern Observatory-Extremely Large Telescope). The Laboratoire d'Astrophysique de Marseille (LAM) is in charge of the “Assembly, Integration, Test and Verification (AIT/V)” activities for ...

SPIE2024

Tumescense monitoring system for diagnosing erectile dysfunction and methods of use

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Systems and methods for monitoring penile tumescence are provided that overcome the drawbacks of previously known systems by providing a wearable formed of a flexible and elastic tube having a plurality of sensors disposed on or embedded within it, the wea ...

2023

Low-Intensity Electrostimulation Enhances Neuroregeneration and Improves Erectile Function in a Rat Model of Cavernous Nerve Injury

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rodrigo Araujo Fraga Da Silva

Background: Neurogenic erectile dysfunction (ED) following radical prostatectomy (RP) is a frequent complication often leading to erectile tissue remodeling and permanent ED. Low-intensity electrostimulation (LIES) has been shown to enhance peripheral nerv ...

ELSEVIER SCI LTD2022

Plant Terpenes on Treating Cardiovascular and Metabolic Disease: A Review

Rodrigo Araujo Fraga Da Silva

The use of medicinal plants as a therapy alternative is old as human existence itself. Nowadays, the search for effective molecules for chronic diseases treatments has increased. The cardiometabolic disorders still the main cause of death worldwide and pla ...

BENTHAM SCIENCE PUBL LTD2021

Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Cardiotrophin-1 (CT-1) is associated with cardiovascular (CV) diseases. We investigated the effect of CT-1 deficiency in the development and progression of atherosclerosis in double knockout Apoe(-/-)ct-1(-/-) mice. Apoe(-/-) C57Bl/6 or Apoe(-/-)ct-1(-/-) ...

Nature Research2020

Low-Intensity Electrostimulation Of Injured Cavernous Nerves Ameliorates Erectile Dysfunction And Promotes Penile Rehabilitation In Rats

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rodrigo Araujo Fraga Da Silva

ELSEVIER SCI LTD2020

Performance and safety of treatment options for erectile dysfunction in patients with spinal cord injury: A review of the literature

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rodrigo Araujo Fraga Da Silva

Background For a large proportion of patients with spinal cord injury, sexuality and reproduction are important issues. However, sparse data exist regarding available treatment options for this patient population. Objectives We sought to review performance ...

WILEY2020

Multi-slice passband bSSFP for human and rodent fMRI at ultra-high field

Rolf Gruetter, Rodrigo Araujo Fraga Da Silva, Olivier Benoit Thomas Reynaud, Ileana Ozana Jelescu

Balanced steady-state free precession (bSSFP) can be used as an alternative to gradient-echo (GE) EPI for BOLD functional MRI when image distortions and signal drop-outs are severe such as at ultra-high field. However, 3D-bSSFP acquisitions have distinct d ...

Academic Press Inc - Elsevier Science2019

Endothelial Function in the Human Cutaneous Microcirculation in Primary Open Angle Glaucoma

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

KARGER2019

An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

Nikolaos Stergiopoulos, Marc Chambon, Olivier Burri, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga, Julien Bortoli Chapalay, Maiia Bragina, Augusto Martins Lima

Despite significant advances in the treatment of cardiovascular diseases, antiplatelet therapies are still associated with a high risk of hemorrhage. In order to develop new drugs, methods to measure platelet function must be adapted for the high-throughpu ...

TAYLOR & FRANCIS INC2019

Long-Term Low-Intensity Electrostimulation Of Injured Cavernosal Nerve Improves Erectile Function Recovery In A Rat Model Of Postprostatectomy Erectile Dysfunction

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rodrigo Araujo Fraga Da Silva

ELSEVIER SCI LTD2019

Novel Concept Enabling an Old Idea: A Flexible Electrode Array to Treat Neurogenic Erectile Dysfunction

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rodrigo Araujo Fraga Da Silva

Introduction: Many studies have shown that electrostimulation of the cavernosal nerve can induce and maintain penile erection. Based on these discoveries, neurostimulation to activate the erectile response has been considered a potential solution to treat ...

ELSEVIER SCI LTD2018

Alamandine abrogates neutrophil degranulation in atherosclerotic mice

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Background Neutrophil-mediated inflammation was recently identified as an active contributor to athero-progression. Therapeutic strategies inhibiting neutrophil degranulation or recruitment were hypothesized to positively impact on plaque vulnerability. In ...

Wiley-Blackwell2017

Apelin-13 treatment enhances the stability of atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

Oxford Univ Press2016

Systems and methods for treating sexual disorders using electro-stimulation

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an ...

2016

Update on the role of angiotensin in the pathophysiology of coronary atherothrombosis

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

BackgroundCoronary atherothrombosis due to atherosclerotic plaque rupture or erosion is frequently associated with acute coronary syndromes (ACS). Significant efforts have been made to elucidate the pathophysiological mechanisms underlying acute coronary e ...

Wiley-Blackwell2015

Diminazene Enhances Stable Phenotype Of Atherosclerotic Plaques

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga

Elsevier Ireland Ltd2015

The Role of the Renin-Angiotensin System in Erectile Dysfunction: Present and Future

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

The renin-angiotensin system (RAS) is a key regulator of the cardiovascular system. Furthermore, clear compelling evidence indicates that this system is an essential modulator of penile erectile. Higher levels of angiotensin (Ang) II, the main component of ...

Springer International Publishing2014

Ace2 Is Expressed In The Corpus Cavernosum And Produces Beneficial Effects Against Hypercholesterolemic-Induced Injures

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014