Publications by François Eric Powolny

Compact solid-state CMOS single-photon detector array for in vivo NIR fluorescence lifetime oncology measurements

Claudio Bruschini, Edoardo Charbon, Krisztian Homicsko, François Eric Powolny, Riccardo Sinisi, Harald Arjan Robert Homulle, David Li

In near infrared fluorescence-guided surgical oncology, it is challenging to distinguish healthy from cancerous tissue. One promising research avenue consists in the analysis of the exogenous fluorophores' lifetime, which are however in the (sub-)nanosecon ...

2016

Fluorescence lifetime imaging to differentiate bound from unbound ICG-cRGD both in vitro and in vivo

Claudio Bruschini, Edoardo Charbon, François Eric Powolny, Riccardo Sinisi, Harald Arjan Robert Homulle

Excision of the whole tumor is crucial, but remains difficult for many tumor types. Fluorescence lifetime imaging could be helpful intraoperative to differentiate normal from tumor tissue. In this study we investigated the difference in fluorescence lifeti ...

Spie-Int Soc Optical Engineering2015

A 65k pixel, 150k frames-per-second camera with global gating and micro-lenses suitable for fluorescence lifetime imaging

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Francesco Regazzoni, François Eric Powolny

This paper presents our work on a 65k pixel single-photon avalanche diode (SPAD) based imaging sensor realized in a 0.35 mu m standard CMOS process. At a resolution of 512 by 128 pixels the sensor is read out in 6.4ps to deliver over 150k monochrome frames ...

Spie-Int Soc Optical Engineering2014

Time-resolved imaging system for fluorescence-guided surgery with lifetime imaging capability

Claudio Bruschini, Edoardo Charbon, Douglas Hanahan, Krisztian Homicsko, François Eric Powolny, Riccardo Sinisi, Harald Arjan Robert Homulle

We present a single-photon camera for fluorescence imaging, with a time resolution better than 100ps, capable of providing both intensity and lifetime images. the camera was fabricated in standard CMOS technology. With this FluoCam we show the possibility ...

Spie-Int Soc Optical Engineering2014

Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability

Claudio Bruschini, Edoardo Charbon, François Eric Powolny, Riccardo Sinisi

We present a single-photon camera for fluorescence imaging capable of providing both intensity and images, with an accuracy better than 100ps; the camera was fabricated in standard CMOS technology. As a first step towards the study of biologically relevant ...

Spie-Int Soc Optical Engineering2013

Comparison of Two Cameras based on Single Photon Avalanche Diodes (SPADs) for Fluorescence Lifetime Imaging Application with Picosecond Resolution

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Francesco Regazzoni, François Eric Powolny

We report on a comparative study of two time-resolved cameras based on digital Single Photon Avalanche Diodes (SPADs) for Fluorescen ce Lifetime Imaging applications. In contrast to standard imagers such as cameras, SPAD imagers provide intensity as well a ...

2013

Micro-Channel Plate Detectors Based on Hydrogenated Amorphous Silicon

Christophe Ballif, Sylvain Dunand, Matthieu Despeisse, François Eric Powolny

A new type of micro-channel plate detector based on hydrogenated amorphous silicon is proposed which overcomes the fabrication and performance issues of glass or bulk silicon ones. This new type of detectors consists in 80-100 μm thick layers of amorphous ...

2010

Time based readout of a silicon photomultiplier (SiPM) for Time Of Flight Positron Emission Tomography (TOF-PET)

Thierry Meyer, Matthieu Despeisse, François Eric Powolny

Time of flight (TOF) measurements in positron emission tomography (PET) are very challenging in terms of timing performance, and should achieve ideally less than 100ps FWHM precision. We present a time-based differential technique to read out SiPMs that ha ...

2009