Publications by Fabiana Pereira Da Costa Fraga

p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Allancer Divino De Carvalho Nunes

Aims:Diminazene aceturate, a putative ACE2 activator, is susceptible to cleavage resulting in the formation of paminobenzamidine (PAB). This study aimed to investigate the effects of PAB in addressing cardiovascular dysfunctions in spontaneously hypertensi ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot, Maiia Bragina, Augusto Martins Lima

Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, cont ...

ELSEVIER SCI LTD2021

Characterization of the Renin-Angiotensin System in Aged Cavernosal Tissue and its Role in Penile Fibrosis

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Maiia Bragina, Babak Ebadi Shirmard

Background: The renin-angiotensin system (RAS) plays an important role in erectile function. The RAS contains 2 major axes: one deleterious, composed of ACE-Ang II-AT1 receptor, and another protective, composed of ACE2-Ang-(1-7)-Mas receptor. While aging i ...

ELSEVIER SCI LTD2020

An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

Nikolaos Stergiopoulos, Marc Chambon, Olivier Burri, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga, Julien Bortoli Chapalay, Maiia Bragina, Augusto Martins Lima

Despite significant advances in the treatment of cardiovascular diseases, antiplatelet therapies are still associated with a high risk of hemorrhage. In order to develop new drugs, methods to measure platelet function must be adapted for the high-throughpu ...

TAYLOR & FRANCIS INC2019

Age-related changes in vascular responses to angiotensin-(1-7) in female mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Fabiana Pereira Da Costa Fraga

2018

Apelin-13 treatment enhances the stability of atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

2018

PROTECTIVE EFFECT OF APELIN-13 AGAINST HYPERCHOLESTEROLEMIA-INDUCED FIBROSIS OF THE CORPUS CAVERNOSUM

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot, Maiia Bragina, Augusto Martins Lima

2018

Ace-Ang Ii-At1 Axis Of Renin-Angiotensin System Is Associated With Aging-Related Penile Fibrosis

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Maiia Bragina

Wiley2017

Apelin-13 treatment enhances the stability of atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

Oxford Univ Press2016

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced By Hypercholesterolemia

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

Wiley-Blackwell2016

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga

IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...

Wiley-Blackwell2015

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Maiia Bragina

Angiotensin (Ang) II contributes to the development of atherosclerosis, while Ang-(1-7) has atheroprotective actions. Accordingly, angiotensin-converting enzyme 2 (ACE2), which breaks-down Aug 11 and forms Ang-(1-7), has been suggested as a target against ...

Elsevier2015

Diminazene Enhances Stable Phenotype Of Atherosclerotic Plaques

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga

Elsevier Ireland Ltd2015

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Fabiana Pereira Da Costa Fraga, Katia Galan

Angiotensin (Ang)-(1-7), acting through the receptor Mas, has athero-protective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and ...

Schattauer2014

An Increased Arginase Activity Is Associated with Corpus Cavernosum Impairment Induced by Hypercholesterolemia

Nikolaos Stergiopoulos, Younouss Faye, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga

IntroductionHypercholesterolemia is a prevalent risk factor for the development of erectile dysfunction (ED), mostly due to an increase in oxidative stress and impaired nitric oxide (NO) bioavailability within the penis. Arginase is an enzyme that shares t ...

Wiley-Blackwell2014

Ace2 Is Expressed In The Corpus Cavernosum And Produces Beneficial Effects Against Hypercholesterolemic-Induced Injures

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014

Angiotensin-Converting Enzyme 2 Is Expressed In Corpus Cavernosum And Produces Beneficial Effects Against Hypercholesterolemia-Induced Injuries

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014

Arginase Inhibition Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Impairment

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014

An Oral Formulation of Angiotensin-(1-7) Reverses Corpus Cavernosum Damages Induced by Hypercholesterolemia

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Danielle Gomes Passos Silva

Introduction The renin angiotensin system plays a crucial role in erectile function. It has been shown that elevated angiotensin-II levels contribute to the development of erectile dysfunction (ED). Oppositely, angiotensin-(1-7) (Ang-[1-7]) mediates penile ...

Wiley-Blackwell2013

ACE2 Activation Protects Corpus Cavernosum Impairment Induced by Hypercholesterolemia

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Fabiana Pereira Da Costa Fraga

Lippincott Williams & Wilkins2013