Publications by Arun Shivanandan

On characterizing protein spatial clusters with correlation approaches

Aleksandra Radenovic, Jayakrishnan Unnikrishnan, Arun Shivanandan

Spatial aggregation of proteins might have functional importance, e.g., in signaling, and nano-imaging can be used to study them. Such studies require accurate characterization of clusters based on noisy data. A set of spatial correlation approaches free o ...

Nature Research2016

Accounting for Limited Detection Efficiency and Localization Precision in Cluster Analysis in Single Molecule Localization Microscopy

Aleksandra Radenovic, Jayakrishnan Unnikrishnan, Arun Shivanandan

Single Molecule Localization Microscopy techniques like PhotoActivated Localization Microscopy, with their sub-diffraction limit spatial resolution, have been popularly used to characterize the spatial organization of membrane proteins, by means of quantit ...

Public Library of Science2015

High-Resolution Correlative Microscopy: Bridging the Gap between Single Molecule Localization Microscopy and Atomic Force Microscopy

Aleksandra Radenovic, Lely Feletti, Georg Fantner, Pascal Damian Odermatt, Arun Shivanandan, Hendrik Georges Deschout, Adrian Pascal Nievergelt, Radek Jankele

Nanoscale characterization of living samples has become essential for modern biology. Atomic force microscopy (AFM) creates topological images of fragile biological structures from biomolecules to living cells in aqueous environments. However, correlating ...

American Chemical Society (ACS)2015

Analytical Methods, Correlative Microscopy and Software Tools for Quantitative Single Molecule Localization Microscopy

Arun Shivanandan

Single Molecule Localization Microscopy (SMLM) techniques, such as PhotoActivated Localization Microscopy (PALM) and STochastic Optical Reconstruction Microscopy(STORM), can get around the diffraction limited resolution of conventional fluorescent microsco ...

EPFL2015

Progress in quantitative single-molecule localization microscopy

Aleksandra Radenovic, Paolo Annibale, Marco Scarselli, Arun Shivanandan, Hendrik Georges Deschout

With the advent of single-molecule localization microscopy (SMLM) techniques, intracellular proteins can be imaged at unprecedented resolution with high specificity and contrast. These techniques can lead to a better understanding of cell functioning, as t ...

Springer2014

Challenges in quantitative single molecule localization microscopy

Aleksandra Radenovic, Marco Scarselli, Arun Shivanandan, Hendrik Georges Deschout

Single molecule localization microscopy (SMLM), which can provide up to an order of magnitude improvement in spatial resolution over conventional fluorescence microscopy, has the potential to be a highly useful tool for quantitative biological experiments. ...

Elsevier2014

MosaicIA: an ImageJ/Fiji plugin for spatial pattern and interaction analysis

Aleksandra Radenovic, Arun Shivanandan

Background: Analyzing spatial distributions of objects in images is a fundamental task in many biological studies. The relative arrangement of a set of objects with respect to another set of objects contains information about potential interactions between ...

BioMed Central2013