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Silvia Scarabelli

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Related publications (3)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Fluorescent sensor proteins to assess the cellular uptake of therapeutic peptides and small molecules

Silvia Scarabelli

The determination of cell membrane permeability and of the absorption and clearance rates is an important step in the pharmacokinetic profiling of a new drug candidate. In a similar way, research in cell biology relies on the development of cell penetratin ...

EPFL2017

Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins

Rudolf Hovius, Kai Johnsson, Kui Thong Tan, Rudolf Griss, Silvia Scarabelli

We are introducing a new approach to evaluate cellular uptake of drugs and drug candidates into living cells. The approach is based on converting the protein target of a given class of compounds into a fluorescent biosensor. By measuring the binding of dif ...

Amer Chemical Soc2017

Genetically encoded biosensor for cell permeability of inhibitors of the p53-HDM2 interaction

Kai Johnsson, Silvia Scarabelli

Wiley-Blackwell2015