Lucía Carolina Leal Esteban

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Related publications (5)

Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases

Daniel Constam, Lucía Carolina Leal Esteban, Benjamin Marcel Daniel Rothé, Céline Gagnieux

Polycystic kidneys frequently associate with mutations in individual components of cilia, basal bodies or centriolar satellites that perturb complex protein networks. In this review, we focus on the RNA-binding protein Bicaudal-C1 (BICC1) which was found m ...

2020

Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6

Daniel Constam, Lucía Carolina Leal Esteban, Benjamin Marcel Daniel Rothé, Simon Fortier, Manuela Isenschmid

2018

Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex

Daniel Constam, Lucía Carolina Leal Esteban, Benjamin Marcel Daniel Rothé, Simon Fortier, Manuela Isenschmid

2018

Functional analysis of Bicc1 and novel interacting proteins in renal tubule cell metabolism and polycystic kidneys

Lucía Carolina Leal Esteban

Genetic disorders known as ciliopathies develop polycystic kidneys, including autosomal dominant and autosomal recessive polycystic kidney diseases (ADPKD and ARPKD). Several signaling pathways including the cAMP/PKA pathway are implicated in driving cyst ...

EPFL2017

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Daniel Constam, Séverine Marguerite Urfer, Florian Urs Bernet, Lucía Carolina Leal Esteban, Benjamin Marcel Daniel Rothé

Loss of the RNA-binding protein Bicaudal-C (Bicc1) provokes renal and pancreatic cysts as well as ectopic Wnt/beta-catenin signaling during visceral left-right patterning. Renal cysts are linked to defective silencing of Bicc1 target mRNAs, including adeny ...

American Society for Microbiology2015

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