Publications by Francesca Volpetti

Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals

Sebastian Maerkl, Francesca Volpetti, Ekaterina Emilova Petrova

Cell-based biosensors have great potential to detect various toxic and pathogenic contaminants in aqueous environments. However, frequently they cannot meet practical requirements due to insufficient sensing performance. To address this issue, we investiga ...

2019

A Microfluidic Biodisplay

Sebastian Maerkl, Francesca Volpetti, Ekaterina Emilova Petrova

Synthetically engineered cells are powerful and potentially useful biosensors, but it remains problematic to deploy such systems due to practical difficulties and biosafety concerns. To overcome these hurdles, we developed a microfluidic device that serves ...

American Chemical Society2017

A system, device and method for multiplexed biomarker diagnostics of ultra-low volume whole blood samples

Sebastian Maerkl, Francesca Volpetti, Francesco Piraino

The invention relates to a microfluidic device for performing digital analysis of a whole blood sample. ...

2017

High-throughput microfluidic platforms applied to immunoassay-based diagnostics and environmental monitoring

Francesca Volpetti

The research presented in this thesis is motivated by the aim to employ microfluidic devices for high-throughput analysis. Two applications, in particular, have been explored: diagnostics and environmental sensing. Miniaturization and multiplexing of labor ...

EPFL2017

A Digital-Analog Microfluidic Platform for Patient-Centric Multiplexed Biomarker Diagnostics of Ultralow Volume Samples

Sebastian Maerkl, Francesca Volpetti, Francesco Piraino

Microfluidic diagnostic devices have the potential to transform the practice of medicine. We engineered a multiplexed digital-analog microfluidic platform for the rapid and highly sensitive detection of 3-4 biomarkers in quadruplicate in 16 independent and ...

Amer Chemical Soc2016

A microfluidic platform for high-throughput multiplexed protein quantitation

Sebastian Maerkl, Jose Luis Garcia Cordero, Francesca Volpetti

We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of capture and detection ...

Public Library of Science2015