Publications by Hans-Anton Lehr

TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer

Nicolas Jean Philippe Guex, Luc Henry, Nathalie Rufer, Emanuela Marina Iancu, Hans-Anton Lehr, George Coukos, Ioannis Xenarios

In experimental mouse models of cancer, increasingly compelling evidence point toward a contribution of tumor associated macrophages (TAM) to tumor lymphangiogenesis. Corresponding experimental observations in human cancer remain scarce although lymphatic ...

Taylor & Francis Inc2016

Characterization of short incubation time effects on chromogen signal obtained by HER2-expressing breast carcinomas using microfluidic immunohistochemistry

Martinus Gijs, Ata Tuna Ciftlik, Hans-Anton Lehr

2013

Microfluidic processor allows rapid HER2 immunohistochemistry of breast carcinomas and significantly reduces ambiguous (2+) read-outs

Martinus Gijs, Ata Tuna Ciftlik, Hans-Anton Lehr

Biomarker analysis is playing an essential role in cancer diagnosis, prognosis, and prediction. Quantitative assessment of immunohistochemical biomarker expression on tumor tissues is of clinical relevance when deciding targeted treatments for cancer patie ...

National Academy of Sciences2013

Interactions between cancer stem cells and their niche govern metastatic colonization

Jörg Hülsken, Ilaria Malanchi, Albert Santamaria Martinez, Hans-Anton Lehr

Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps. Although dissemination of tumour cells seems to be an early and frequent event, the successf ...

2012

Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model

Hubert van den Bergh, Elodie Debefve, Hans-Anton Lehr

OBJECTIVES: The pre-treatment of tumour neovessels by low-level photodynamic therapy (PDT) improves the distribution of concomitantly administered systemic chemotherapy. The mechanism by which PDT permeabilizes the tumour vessel wall is only partially know ...

Oxford University Press2012

Protein-Binding Microarray Analysis of Tumor Suppressor AP2 alpha Target Gene Specificity

Horst Vogel, Nicolas Mermod, Luigino Grasso, Tanja Egener-Kuhn, Jan Kerschgens, Hans-Anton Lehr

Cheap and massively parallel methods to assess the DNA-binding specificity of transcription factors are actively sought, given their prominent regulatory role in cellular processes and diseases. Here we evaluated the use of protein-binding microarrays (PBM ...

Public Library of Science2011

Leukocyte-endothelial cell interaction is necessary for photodynamic therapy induced vascular permeabilization

Hubert van den Bergh, Elodie Debefve, Hans-Anton Lehr

Photodynamic therapy (PDT) affects vascular barrier function and thus increases vessel permeability. This phenomenon may be exploited to facilitate targeted drug delivery and may lead to a new clinical application of photodynamic therapy. Here, we investig ...

2011

Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography

Bernard Lanz, Rolf Gruetter, David Viertl, Carole Poitry-Yamate, Hans-Anton Lehr

3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[F-18]fluoro-d-glucose ([F-18]FDG) but less sensitive. We studied the capaci ...

Elsevier2011

Lighting-up cancerous cells and tissues with lanthanide luminescence

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Hans-Anton Lehr

2011

Bioconjugated lanthanide luminescent helicates as multilabels for lab-on-a-chip detection of cancer biomarkers

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Venkataragavalu Sivagnanam, Bo Song, Vanesa Fernandez Moreira, Hans-Anton Lehr

The lanthanide binuclear helicate [Eu2(LC2(CO2H))3] is coupled to avidin to yield a luminescent bioconjugate EuB1 (Q ¼ 9.3%, s(5D0) ¼ 2.17 ms). MALDI/TOF mass spectrometry confirms the covalent binding of the Eu chelate and UV-visible spectroscopy allows o ...

2010

Fast Immunohistochemical BioMarker Detection Device for Cancer Tissue Slices

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Bo Song, Ata Tuna Ciftlik, Hans-Anton Lehr

2010

Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Venkataragavalu Sivagnanam, Bo Song, Hans-Anton Lehr

PDMS-based microfluidic devices combined with lanthanide-based immunocomplexes have been successfully tested for the multiplex detection of biomarkers on cancerous tissues, revealing an enhanced sensitivity compared to classical organic dyes. ...

2009

The MRL mouse repairs both cryogenic and ischemic myocardial infarcts with scar

Yann Barrandon, Lukas Kappenberger, Hans-Anton Lehr

Objective: The MRL mouse strain shows extraordinary wound healing capacities. Some years ago, Leferovich et al. (Proc Natl Acad Sci U. S. A. 2001;98:9830-35) have reported the absence of scar formation after cryogenically-induced right ventricular myocardi ...

Elsevier2008